Title:
NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/1988/005781
Kind Code:
A1
Abstract:
Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.
Inventors:
YOSHIHAMA MAKOTO (JP)
TAMURA KOJI (JP)
MIYATA NOBUO (JP)
NAKAYAMA SHOJI (JP)
NAKAKOSHI MASAMICHI (JP)
TAMURA KOJI (JP)
MIYATA NOBUO (JP)
NAKAYAMA SHOJI (JP)
NAKAKOSHI MASAMICHI (JP)
Application Number:
PCT/JP1988/000114
Publication Date:
August 11, 1988
Filing Date:
February 05, 1988
Export Citation:
Assignee:
SNOW BRAND MILK PRODUCTS CO LTD (JP)
International Classes:
C07J1/00; C12P33/06; A61K31/565; (IPC1-7): C07J1/00; C12P33/06
Foreign References:
| JPS58179498A | 1983-10-20 |
Other References:
CHEMICAL ABSTRACTS, Vol.92, No.9 3 March 1980 (03. 03. 80) (Columbus, Ohio, U.S.A.), page 315, see Abstract No. 72382y Bull. Soc. Chim. Fr., Nos. 1 to 2, pt. 2, (1979), FAVERO J et al (Bioconversion of 9beta, 10alpha Steroids by Rhizopus Arrhizus Fischer: Carbon-13 NMR Study in the Retro-Steroid Series), p56-60
Tetrahedron Letters, No. 13, (1968), KAZUO TORI et al (Further Evidence for Distorted Conformation of Ring B in Some 6beta-Substituted Delta4-3-Ketosteroids) p1657-1660
CHEMICAL ABSTRACTS, Vol. 95, No. 7, 17 August 1981 (17. 08. 81) (Columbus, Ohio, U.S.A.), pages 95 to 96, see Abstract No. 55345h J. Steroid Biochem., Vol. 14, No. 4, (1981), SEKIHARA HISAHIRO et al (6beta-Hydroxy-4-Androstene-3, 17-Dione: A Potent Amplifier of the Kaliuretic Action of Aldosterone), p327-329
Chemical Abstracts, Vol. 74, No. 1, 4 January 1971 (04. 01. 71) (Columbus, Ohio, U.S.A.), page 4, see Abstract No. 111q Acta Endocrinol. (Copenhagen), Vol. 65, No. 1, GUSTAFSSON JAN A. et al (Metabolism of C19 Steroids in Rat Liver. 6 Hydroxylation of 4-Androstene-3, 17-Dione in Rat Liver Microsomes), p84-94
See also references of EP 0300062A4
Tetrahedron Letters, No. 13, (1968), KAZUO TORI et al (Further Evidence for Distorted Conformation of Ring B in Some 6beta-Substituted Delta4-3-Ketosteroids) p1657-1660
CHEMICAL ABSTRACTS, Vol. 95, No. 7, 17 August 1981 (17. 08. 81) (Columbus, Ohio, U.S.A.), pages 95 to 96, see Abstract No. 55345h J. Steroid Biochem., Vol. 14, No. 4, (1981), SEKIHARA HISAHIRO et al (6beta-Hydroxy-4-Androstene-3, 17-Dione: A Potent Amplifier of the Kaliuretic Action of Aldosterone), p327-329
Chemical Abstracts, Vol. 74, No. 1, 4 January 1971 (04. 01. 71) (Columbus, Ohio, U.S.A.), page 4, see Abstract No. 111q Acta Endocrinol. (Copenhagen), Vol. 65, No. 1, GUSTAFSSON JAN A. et al (Metabolism of C19 Steroids in Rat Liver. 6 Hydroxylation of 4-Androstene-3, 17-Dione in Rat Liver Microsomes), p84-94
See also references of EP 0300062A4
Download PDF:
Previous Patent: 14-FLUORODAUNORUBICIN DERIVATIVES
Next Patent: NOVEL 7beta-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
Next Patent: NOVEL 7beta-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION