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WO/2024/096102A1 |
The present invention provides a pre-sintered body and a composition which are for obtaining a zirconia sintered body that, after short sintering in which the time of holding at a maximum sintering temperature is 10 minutes or less, main...
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WO/2024/049878A3 |
Provided herein, inter alia, a composition or an engineered gene delivery composition including nanoparticles and polymers (e.g., poly(disulfide amine) or PDSA polymers) containing chemically distinct functional side chain groups and dif...
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WO/2024/098068A1 |
The present disclosure provides mixed-surface polyamidoamine (PAMAM) polymers comprising cationic surface groups and neutral surface groups. Also provided are scavenging apparatuses, microfibers, filters, and other devices comprising the...
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WO/2024/092856A1 |
The present invention relates to the technical field of biomedical materials, and particularly, to a super-hydrophobic self-cleaning anticoagulant composite coating material, a method for preparing same, and use thereof. In the provided ...
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WO/2024/094890A1 |
An implant for cartilage and meniscus repair and formed from decellularized cartilage extracellular matrix (dECM) ink is described. The dECM ink has a dECM concentration of 5 to 10% (w/v), preferably a pH of 10-12, and the dECM in the im...
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WO/2024/094556A1 |
The present invention discloses a method for generating a plurality of biocompatible fibroin fibres (6) generated from the turbulent mixing produced in the inner mixing region of a nebulizer, among a dope stream comprising a dope solutio...
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WO/2024/094887A1 |
The present invention relates to the production of skin substitutes with a defined ratio of blood endothelial cells (BEC), to lymphatic endothelial cells (LEC), and their use in medicine.
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WO/2024/095956A1 |
Provided is a method for modifying crystalline calcium phosphate particles into amorphous calcium phosphate by wet grinding using a bead mill, without causing particle agglomeration. A slurry that contains calcium phosphate particles and...
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WO/2023/034614A9 |
Systems and methods for nerve repair can include a polymer configured to form an elongated conduit to receive an in vivo nerve therein and provide a mechanical stabilization to the in vivo nerve. The polymer can be configured to degrade ...
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WO/2024/097403A1 |
A dissolvable stretch ring (100) including a biodegradable polymer positioned on or adjacent to at least one haptic of an intraocular lens (IOL) is described. The dissolvable stretch ring (10) can be included in an IOL arrangement, compr...
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WO/2024/097250A1 |
This disclosure provides a respirator}- tract insertable device comprising a mesh that carries a probiotic composition. For example, a method of treating or preventing chronic obstructive pulmonary disease (COPD) or a respiratory infecti...
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WO/2024/096942A1 |
A medical device that is at least partially formed of a metal alloy that includes at least 15 awt.% rhenium, and a medical device that is partially or fully formed of such metal alloy.
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WO/2024/097114A1 |
The disclosed inventions relate to an improved bioceramic coated product and methods of characterizing coated products. More specifically, the disclosed inventions relate to an improved bioceramic coated product comprising bioceramic par...
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WO/2024/096401A1 |
One aspect relates to a pharmaceutical composition for wound healing or skin tissue regeneration, the pharmaceutical composition containing an extracellular matrix and a kelp extract. According to one aspect, the extracellular matrix and...
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WO/2024/040103A3 |
The present invention relates to the discovery that various proteins are enriched in the amniotic fluid of fetuses with open neural tube defects (NTDs). The invention includes methods for the diagnosis of open NTD based upon the levels a...
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WO/2024/072868A3 |
Three-dimensional (3D) bioprinting has tremendous potential to aid in the creation of engineered tissues and organs that are so desperately in need. In this disclosure, a new type of bio-ink for 3D bioprinting made of sheared slurries of...
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WO/2024/086893A1 |
Dilute zinc alloys and processes for their manufacture are provided. The alloys contain iron and/or copper as major alloying metals and are prepared using hot extrusion and optional post-extrusion annealing. The alloys exhibit high stren...
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WO/2024/089422A1 |
An apparatus (105) for manufacturing a tubular biological structure (165) comprises a tubular member (150) configured to be rotated, wherein the tubular member (150) comprises a tubular wall extending from a first end (151) and a second ...
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WO/2024/089699A1 |
Formulations usable for additive manufacturing of a three-dimensional object featuring, in at least a portion thereof, a biological and/or biocompatible material, which utilize minocycline and/or any other compound that features a tetrac...
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WO/2024/091513A1 |
The present disclosure provides polymeric matrices comprising calreticulin (CRbT) and methods of producing and using such matrices. The polymeric matrices are useful in treatment of wounds (e.g., chronic diabetic wound).
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WO/2024/091971A1 |
Described herein are compositions and methods for bone regeneration and the treatment of bone diseases, bone defects, and injuries to bone. The compositions and methods include treating bone regenerative implants with lyoprotectants to e...
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WO/2024/091668A1 |
A polymer ring (10) configured to fit around or adjacent to an intraocular lens is described. The polymer ring (10) comprises a hyaluronic acid derivative and a drug. An intraocular lens comprising a polymer ring (10) positioned on or ad...
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WO/2024/087828A1 |
The present invention relates to the technical field of cell culture and processing, and provides a PET film for cell culture in cell and gene therapy, and the use thereof. The PET film is a long-scroll-like coiled film, and forms a cyli...
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WO/2024/092015A1 |
An in vitro method of preparing a population of hypoimmune mammalian stem cells includes providing a population of isolated mammalian stem cells, wherein the isolated mammalian stem cells express a cell adhesion molecule; and modifying t...
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WO/2024/082416A1 |
The present invention relates to a collagenous fiber composite membrane for repairing nerve injuries. The collagenous fiber composite membrane comprises: an anti-adhesion layer, an elastic connection layer chemically cross-linked with th...
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WO/2024/084040A1 |
The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10...
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WO/2024/025937A9 |
An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crossli...
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WO/2024/084686A1 |
Artificial skin containing photochromic material that changes color when irradiated with ultraviolet light.
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WO/2024/086171A1 |
The present invention provides a bone graft such as an allograft and a method for releasing growth factors from tissues (e.g., bone marrow, bone matrix, periosteum, and/or endosteum) having native living cells. Also provided are a compos...
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WO/2024/082029A1 |
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the i...
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WO/2024/086253A1 |
Liquid compositions containing at least one S-nitrosothiol (RSNO), such as S-nitroso-N- acetylpenicillamine (SNAP) and S -nitrosoglutathione (GSNO), and at least one alkanediol or alkanediol oligomer/polymer are provided. To modulate the...
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WO/2024/084416A1 |
A medical device (1) for repairing a lesion (200) in a spinal cord (2) or in a peripheral nerve comprises a biocompatible flexible support (10) made of expanded polytetrafluoroethylene (ePTFE). Stem cells (20) suitable for being oriented...
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WO/2024/085257A1 |
The present invention addresses the problem of providing a three-dimensional tissue culture and a method for producing the same. The problem is solved by this method for producing a three-dimensional tissue culture, the method comprising...
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WO/2024/082070A1 |
There is provide the use of a specific magnesium phosphate xerogel as a coating for bone implants; a coating for a bone implant comprising the xerogel as well as a bone implant, wherein a surface of the implant is covered by such a coati...
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WO/2024/080482A1 |
The present invention relates to a composition for endometrial regeneration containing a uterus derived decellularized extracellular matrix (UdECM) and a manufacturing method therefor. Characterized by containing uterus derived decellula...
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WO/2024/080382A1 |
The zirconia ceramic according to an embodiment has a crystal structure comprising zirconium, silver, and oxygen ions. The method for producing a zirconia ceramic according to an embodiment includes a sediment formation step (S1) and a f...
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WO/2024/078355A1 |
Provided are a biological mesh, a preparation method therefor a use thereof. The biological mesh comprises a matrix having an active group, the matrix being modified with a phosphorylcholine compound, and the phosphorylcholine compound b...
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WO/2024/080737A1 |
The present invention relates to a bone graft material and a bone formation method using same and, more specifically, to a bone graft material and a bone formation method using same, wherein the bone graft material is designed such that,...
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WO/2024/081310A1 |
Described herein are engineered mammalian cells comprising a reduction in the level or function of one or more of a major histocompatibility complex (MHC) class I protein complex component, optionally, a MHC class II protein complex comp...
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WO/2024/078253A1 |
An anti-calcification method for a bioprosthetic tissue, and a bioprosthetic tissue. The anti-calcification method for a bioprosthetic tissue comprises: putting a bioprosthetic tissue at least partially fixed in a cross-linking manner in...
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WO/2024/081153A1 |
An alternating vacuum and pressure system for decellularizing a bone matrix includes piping having a first end open to atmospheric pressure and a second end open to atmospheric pressure, and a subset of piping that forms a loop, a chambe...
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WO/2024/081898A1 |
The present disclosure provides compositions, systems, and methods related to cellular transduction. In particular, the present disclosure provides compositions, systems, and methods pertaining to implantable macroporous scaffolds that f...
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WO/2024/081656A1 |
Described herein are methods of using bone sialoprotein (BSP) to promote alveolar bone healing, for example, to improve bone preservation following tooth extraction, in preparation for a dental implant or other restorative device. Also d...
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WO/2024/081452A1 |
A composition comprising a hydrogel includes a polymer of formula (1), at least one repeating unit of which comprises BO2H2. Methods of making such hydrogels and methods of encapsulating cells using such hydrogels are also disclosed herein.
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WO/2024/022079A9 |
A use of a human mesenchymal stem cell sheet in the preparation of a drug for treating uterine scars, and a use of a human mesenchymal stem cell sheet in the preparation of a composition for treating a uterine scar in a subject. The huma...
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WO/2024/080661A1 |
The present invention relates to vMSC, which is a stem cell that is newly identified and has angiogenic properties. vMSCs cultured under specific culture conditions and identified, according to the present invention, are novel MSCs that ...
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WO/2024/081309A1 |
Described herein are engineered mammalian cells comprising a reduction in the level or function of a major histocompatibility complex (MHC) class I protein complex component, and, optionally, a MHC class II protein complex component and/...
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WO/2024/074119A1 |
A recombinant collagen and the use thereof in cartilage repair matrix. The recombinant collagen comprises a sequence as shown in SEQ ID No.1; the amino acid sequence of the recombinant collagen comprises N basic repeating units, and the ...
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WO/2024/075118A1 |
The invention provides a dental or subperiosteal implant having a porous polymeric structure and uses thereof in the method of treatment of periodontal diseases, conditions and symptoms.
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WO/2024/076771A1 |
Magneto-responsive properties are traditionally imparted to scaffold systems via integration of iron oxide-based magnetic nanoparticles (MNPs), yet poor understanding of long-term MNP toxicity presents a significant translational chall...
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