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WO/2024/015200A1 |
Methods are disclosed for preparing polyurethane or polyurea polymers with crosslinks between polymer chains as well as orthopedic devices and other medical implant devices formed by the polyurethane or polyurea polymers and related meth...
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WO/2024/014972A2 |
The subject of the invention is a recombinant hybrid protein RElSmR composed sequentially of 3 resilin domains, 1 K+ domain, 1 MMP domain, 3 elastin domains, 1 K+ domain, 4 elastin domains, 1 K+ domain, 4 elastin domains, 1 K+ domain, 3 ...
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WO/2024/015521A1 |
A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alke...
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WO/2024/014497A1 |
The purpose of the present invention is to provide: a fibrin gel sheet for cell transplantation, in which cells are enclosed uniformly dispersed while at the same time the sheet has a larger size than heretofore available; and a method f...
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WO/2024/014892A1 |
The present invention relates to a fibrocartilage-derived bioink composition, a bone graft composition containing same, and a manufacturing method therefore. More specifically, it is identified in the present disclosure that the inner, m...
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WO/2024/010858A1 |
A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may inclu...
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WO/2024/010350A1 |
The present invention provides an injectable hydrogel and a preparation method therefor, the injectable hydrogel comprising a matrix monomer and reduced graphene oxide coated with a block copolymer, wherein the matrix monomer comprises a...
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WO/2024/008965A1 |
The present invention provides a hydrogel comprising hydroxyethyl cellulose (HEC) and bacteriophages.
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WO/2024/010278A1 |
The present invention pertains to artificial skin using fibroblasts and keratinocytes, and more specifically to a method for manufacturing artificial skin using cells differentiated from induced pluripotent stem cells. To this end, a met...
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WO/2024/010720A1 |
Cardiac replacement valves that are anti-biofilm and tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are hyd...
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WO/2024/007051A1 |
The present invention relates to a biocompatible implantable scaffold comprising a first scaffold portion comprising a first array of spaced walls having a first height, wherein the walls of the first array of spaced walls are connected ...
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WO/2024/010279A1 |
The present invention relates to artificial skin using fibroblasts and keratinocytes, and, more specifically, to a device for producing artificial skin using cells differentiated from induced pluripotent stem cells. In this regard, the d...
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WO/2024/010873A1 |
Curable resins and polymeric materials generated therefrom containing property-modifying solids capable of chemical- and site-selective removal from printed products, and such resins and materials can be used to generate devices with min...
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WO/2024/003287A1 |
Bioink comprising modified fibers of MFC with a diameter of about 100-400 nm.
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WO/2024/000860A1 |
A self-adhesive absorbable biological patch, comprising a base layer and an adhesive coating on the base layer. The base layer is a biological material, and the adhesive coating is a polyacrylic acid cross-linked copolymer grafted with a...
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WO/2024/004747A1 |
The present invention addresses the problem of providing a transplant material suitable for clinical application, without using an artificial material. The problem is solved by providing a method for producing a cellular structure, the m...
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WO/2024/004981A1 |
[Problem] To provide: a collagen-rich organic composition; a biomaterial using the collagen-rich organic composition as a starting material; a biomaterial or other products containing collagen as a main ingredient; a method for producing...
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WO/2024/001217A1 |
Provided in the present invention are a treatment method for biological tissue and a medical material. The treatment method comprises the following steps: performing cross-linking treatment on biological tissue, the surface of the biolog...
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WO/2023/147185A9 |
Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulate T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansi...
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WO/2024/006353A1 |
A method of preparing sterile human placental allografts by providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; removing any visible blood, blood clots, and/or blood components from the human plac...
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WO/2024/006612A1 |
A method of forming an immunomodulatory implant operatively arranged to chemotactically facilitate bone morphogenesis, the method including forming a matrix of a first material, the matrix including an outer surface, and a plurality of p...
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WO/2024/005593A1 |
The present invention relates to a composition for inducing ligamentization of tendons, comprising anterior cruciate ligament-derived stem cells. The use of the composition can inhibit fibrosis in tendon grafts used for anterior cruciate...
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WO/2024/003201A1 |
One aspect of the invention relates to a method for making a three-dimensional hydrogel bioimplant, characterized by geometrical structures in sub-millimeter size range. The method comprises the provision of a first composition susceptib...
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WO/2024/006421A1 |
The disclosure provides compositions and methods for directing the growth of blood vessels in a tissue graft. The compositions and methods provide the advantage of directing the growth, size and pattern of blood vessels from the peripher...
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WO/2024/002806A1 |
Recombinant bacterial collagen-like protein with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 characterized in that the amino acid sequence comprises a deletion of at least 38 amino ...
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WO/2024/006343A1 |
A sterile micronized composition prepared from intact human placental tissue that is configured for wound healing. The sterile micronized composition includes micronized human amnion; micronized human chorion; and micronized human interm...
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WO/2024/000861A1 |
Aiming at the problems of insufficient adhesion, low operability, and insufficient convenience and portability of existing tissue sealing materials, the present invention provides a PEG two-component self-adhesive absorbable biological m...
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WO/2024/001242A1 |
A polypeptide and a use thereof are provided. The polypeptide comprises an N-terminal sequence and a C-terminal sequence, the N-terminal sequence comprising one or more repeating units, and said repeating unit comprising an amino acid se...
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WO/2024/005367A1 |
The present invention relates to a method for manufacturing a bearing element having a uniform hydrophilic layer, and a bearing element manufactured thereby and, more specifically, to a method for manufacturing a bearing element having a...
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WO/2024/000049A1 |
The present invention pertains to the field of biomaterials for covering and protecting bone grafts/biomaterials, and relates more specifically to a titanium mesh covered with a biocompatible polypropylene film that aims to increase bone...
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WO/2023/245812A1 |
A cell sheet clamping device, a use method, and a preparation method for a neurorestorative material. The cell sheet clamping device comprises a frame, a fixed plate being fixedly arranged on the frame. A first clamping member is adjusta...
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WO/2023/246135A1 |
The present disclosure relates to a peptide, a peptide-modified SIS membrane, a method for preparing same, and use thereof. Specifically, the present disclosure relates to an oligopeptide, a chimeric peptide containing the oligopeptide, ...
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WO/2023/250488A1 |
Improved dental appliances and polymeric sheet compositions are disclosed. The polymeric sheet compositions are useful for making dental appliances having outer layers comprised of a material having a modulus of from about 1,000 MPA to 3...
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WO/2023/250519A1 |
The present disclosure relates to an implantable vascular graft material, including: a substrate including a graft material, the substrate defining a top surface and a bottom surface; and one or more bispecific binding partners having a ...
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WO/2023/247763A1 |
This invention relates to an artificial tubular graft comprising at least three layers, each layer comprising a population of cells and each population of cells comprising a different cell type. Also provided is a method of constructing ...
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WO/2023/246642A1 |
Disclosed are a composition for treating spinal cord injury, a preparation method therefor and a use thereof. The composition comprises induced neural stem cells, fibrin and thrombin, and is particularly applicable for fully injured and ...
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WO/2023/249065A1 |
A tissue regeneration promotion sheet (10) comprises a cell retention sheet (12), which is a non-woven fabric that contains fibers mainly composed of polycaprolactone and are capable of allowing permeation of a cell suspension containing...
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WO/2023/250051A1 |
An implantable bone graft device comprising a bioresorbable casing comprising a cavity for receiving and containing a fill material, the bioresorbable casing comprising one or. more seams. configured to remain joined after trimming acros...
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WO/2023/250102A1 |
A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at le...
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WO/2023/245813A1 |
Provided are a composition and the use thereof in preparation of a cell membrane. The composition comprises an ITS cell culture additive, dexamethasone and vitamin C. The composition can be used to prepare a cell membrane by means of a g...
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WO/2023/241094A1 |
Provided in the present invention is a method for preparing a tissue engineering liver on the basis of a plant decellularized scaffold. The method comprises the following steps: S1, cutting out the stem of hollow water celery; S2, immers...
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WO/2023/243166A1 |
The present invention addresses the problem of effectively promoting granulation in a dermal defect or a subcutaneous tissue defect caused by a severe burn. To solve this problem, provided is a cell to be used for treating a burn, said c...
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WO/2023/242735A1 |
The present invention relates to a granulate for manufacturing a personalized dental device, wherein the individual granulate of the granulate has a maximum particle size of 5 mm, wherein the granulate consist of a thermoplastic polymer ...
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WO/2023/244012A1 |
The present invention relates to a composite, a method for manufacturing same, and a filler composition for molding, using same, the composite comprising: biodegradable particles the particle-size distribution (PSD) of which is controlle...
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WO/2023/244438A1 |
An implant includes a substrate and a coating. The substrate includes a first outer surface. The coating is disposed on the first outer surface. The coating includes eighty percent titanium dioxide and twenty percent aluminum oxide.
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WO/2023/244011A1 |
The present invention relates to a composite, a manufacturing method therefor, and a cosmetic filler composition using same, the composite comprising biodegradable particles with a network structure therein, and a water-soluble polymer. ...
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WO/2023/240252A1 |
Disclosed are compositions, devices, kits, and methods for prevention and/or treatment of Staphylococcus infection. In specific embodiments, Staphylococcus are S. pseudintermedius and/or S. aureus. Aspects of the present disclosure can b...
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WO/2023/236379A1 |
Disclosed herein is an electroactive titanium support-reinforced composite film and a method for preparing same. The composite film comprises a titanium support and a film material coating the titanium support. The titanium support has a...
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WO/2023/237957A1 |
Methods and apparatus for coating bone particles are provided. The methods and apparatus comprise providing a first mesh having a first set of openings to allow coating liquid and bone particles of a select size therethrough and bone par...
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WO/2023/240276A1 |
The present disclosure describes surface coatings and methods of applying surface coatings to improve the performance of fluid manipulation technologies. The surface coatings may provide increased force applied to the fluid, better fluid...
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