Title:
BIOMATERIAL-INK FOR 3D PRINTING
Document Type and Number:
WIPO Patent Application WO/2024/072868
Kind Code:
A3
Abstract:
Three-dimensional (3D) bioprinting has tremendous potential to aid in the creation of engineered tissues and organs that are so desperately in need. In this disclosure, a new type of bio-ink for 3D bioprinting made of sheared slurries of biomaterial hydrogel, in particular alginate hydrogel having micro-capillary structure (Capgel), in particular Capgel having increased stackability and thus self-assembly capability through the formation of a polyelectrolyte complex "skin" on the outer surfaces of the Capgel block with poly-L-lysine (PLL) coating prior to printing needle extrusion is provided as injectable biomaterial tissue scaffolding system, so that such stackable structure as weave patterns and cylindrical structures can be successfully printed with the new Capgel bio-ink. Further, the micro-capillary structure inherent in the original Capgel blocks is retained in the printed bio-ink making up the larger 3D structures and allows for cell culture in it.
Inventors:
WILLENBERG BRADLEY (US)
KEAN THOMAS (US)
PANARELLO ANDREW (US)
KEAN THOMAS (US)
PANARELLO ANDREW (US)
Application Number:
PCT/US2023/033827
Publication Date:
May 10, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
UNIV CENTRAL FLORIDA RES FOUND INC (US)
International Classes:
A61L27/38; B33Y70/00; B33Y80/00; C08L5/04; C08L89/06
Attorney, Agent or Firm:
VAN DYKE, Timothy, H. et al. (US)
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