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WO/2023/076688A1 |
Disclosed are methods, devices, systems, and filter media for the removal of contaminants (e.g., oils, per- and polyfluoroalkyl substances (PFAS), and/or microbes) from a fluid. The filter media can comprise a fiber (e.g., a hydrophobic ...
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WO/2023/077086A1 |
Provided herein are methods and compositions for the separation of an adeno-associated virus (AAV) particle from a mixture of the AAV and at least one contaminant using anion exchange chromatography. These methods and compositions allow ...
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WO/2023/074729A1 |
The purpose of the present invention is to provide a cell adsorption material that efficiently adsorbs LAP+ immune cells such as LAP+ T cells and LAP+ platelets, and other such cells. A cell adsorption material formed from fibers or part...
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WO/2023/067038A1 |
The present invention relates to a process for purifying an oligonucleotide from a mixture comprising said oligonucleotide and a solid support, the process comprising desalting the mixture by size exclusion chromatography in which simult...
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WO/2023/068999A1 |
A device (100, 100´, 100´´) for separating an analyte (200) from other components in an electrolytic solution. The device comprises a housing (114, 115, 116, 117, 118, 119) provided with a solution inlet (104) and a solution outlet (1...
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WO/2023/065039A1 |
The present disclosure includes methods of removing an environmental contaminant from media comprising the environmental contaminant as well as methods for preparing a composite material that may be useful in such methods. The methods of...
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WO/2023/064613A1 |
The present disclosure describes a method, a system, and a computer program product of performing a separation on a field flow fractionator. In an embodiment, the method, the system, and the computer program product include executing, by...
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WO/2023/063795A1 |
An exosome extraction system is provided. The exosome extraction system according to an embodiment of the present invention may comprise: a raw material supply unit for supplying a cell fluid containing cells; a cell disruptor which disr...
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WO/2023/063928A1 |
Provided are methods of extracting lithium from a lithium containing solution, as well as the resulting compositions. The method includes supplying a lithium containing solution to a lithium capture step, the lithium capture step being o...
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WO/2023/064320A1 |
Continuous monitoring of density in lithium extraction and recovery using inertial density sensors is described herein. Lithium recovery methods and processes using inertial density sensors are also described herein. A method comprises d...
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WO/2023/064607A1 |
The present disclosure describes an apparatus of managing solvent associated with a field flow fractionator. In an exemplary embodiment, the apparatus includes (1) a union assembly coupled to a detector flow output from at least one dete...
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WO/2023/064753A1 |
The devices and methods of the present invention can be used to capture and remove COVID-19 mediating nanoparticles and/or exosomes associated with COVID-19 or similar disease from the circulatory system of patients in need thereof, incl...
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WO/2023/060622A1 |
Disclosed in the present application is an enrichment tube for enriching total flavones in an epimedium brevicomu maxim leaf extracting solution, the tube comprising a tube body, Teflon gaskets, and a resin layer, wherein an inlet is for...
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WO/2023/064949A1 |
The subject invention pertains to mixed mode chromatography ligands and chromatography matrices suitable for the purification of proteins from biological sources or biological samples. Methods of making chromatography matrices comprising...
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WO/2023/057994A1 |
The present invention provides an effective High Performance Liquid Chromatography (SE-HPLC) method to separate or resolve the pre-peak and main peak (fusion protein). The method provides improved sharpness and resolution of pre-peak imp...
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WO/2023/059656A1 |
The disclosure relates to a method of producing a multi-metal catalyst film and of producing a reactor system for catalytic removal of a wide variety of contaminants (for example, nitrate, nitrite, perchlorate, chlorate, chromate, selena...
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WO/2023/057509A1 |
The invention relates to a polymeric composition for thickening a cosmetic or detergent composition, said polymeric composition comprising either at least one crosslinked polymer crosslinked with at least one labile crosslinker and at le...
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WO/2023/058180A1 |
This foreign matter removal device removes foreign particles from a fluid to be treated which contains foreign particles. This foreign matter removal device is equipped with: a storage container which has an intake port, an adsorption di...
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WO/2023/057995A1 |
The present invention provides an effective High Performance Liquid Chromatography (SE-HPLC) method to separate or resolve the pre-peak, post-peak and main peak of CTLA4-IgG1 fusion protein, where pre-peak resolution is more than 1.3. Th...
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WO/2023/059798A1 |
The present invention relates to methods for separating enantiomers of 5-phenyl and 5- naphthyl substituted 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl)phthalazin-l(2H)
-ones using N-Boc-L-phenylalanine, N-Boc-D-phenylalanine, and simila...
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WO/2023/052126A1 |
A cyclic chromatographic purification method for the isolation of a product (P) from a feed mixture (F) consisting of the product (P) and at least two further components representing weakly adsorbing impurities (W) and strongly adsorbing...
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WO/2023/052627A1 |
The present invention relates to improved industrial scale processes for removing metal cations, such as copper, from blood plasma derived albumin products and pharmaceutical compositions derived therefrom. The albumin sample is contacte...
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WO/2023/051885A1 |
An apparatus for refining proteins or other biomolecules in biological compositions, such as for separation of proteins from milk, whey, blood plasma, fermentation broth, or similar.
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WO/2023/055879A1 |
Provided herein are methods of separating molecular species of a guanine-rich oligonucleotide from a mixture of molecular species, wherein at least one molecular species of the mixture is a quadruplex formed from the guanine-rich oligonu...
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WO/2023/053031A1 |
The present invention is directed to the use of anion exchange chromatography to produce a CTLA4-Ig fusion protein with improve glycan.
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WO/2023/053030A1 |
The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention providescytotoxic T-lympho...
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WO/2023/052358A1 |
Methods for the monitoring of quality and efficiency of chromatography columns operated in continuous mode without disruption of column operation by monitoring buffer change followed by smoothing and derivation of the recorded values.
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WO/2023/053032A1 |
The present invention relates to purification process of pharmacologically active cytotoxic T lymphocyte-associated 4-immunoglobulin (CTLA4-lg) fusion protein by using three column chromatography steps that provides purified form of the ...
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WO/2023/045219A1 |
The present invention belongs to the technical field of environmental protection and biomedical functional materials. Disclosed are a preparation method and an application of a high site density adsorbent suitable for selectively separat...
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WO/2023/047368A1 |
The present invention relates to an improved method of quantification and/or estimation of purity of antibody or fusion protein from a protein mixture containing impurity by providing long term sample stability. The invention provides a ...
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WO/2023/049383A1 |
Compositions, systems, and methods for selectively leaching and/or extracting lithium from sedimentary deposits and other resources are generally described.
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WO/2023/043718A1 |
Methods and systems are provided to improve consistency and robustness in chromatography, for example, in operations of multi-column chromatography systems.
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WO/2023/043819A1 |
A method for separating sugars, sugar alcohols or a combination thereof by bringing an aqueous solution of sugars, sugar alcohols or a combination thereof into contact with a collection of strong acid cation exchange resin particles, whe...
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WO/2023/040534A1 |
A method for lithium adsorption in a carbonate- and/or sulfate-containing solution, comprising using an aluminum-based lithium adsorbent for adsorption of lithium ions in the carbonate- and/or sulfate-containing solution, after the adsor...
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WO/2023/032815A1 |
This metal recovery material includes cyanobacteria of genus Leptolyngbya.
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WO/2023/032883A1 |
Provided is a microfluidic device characterized by comprising a tunnel-shaped separation flow path, a columnar obstacle which is provided inside the separation flow path, and a ligand which is supported on the surface of the obstacle, wh...
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WO/2023/031511A1 |
Herein is disclosed a process for selection of a pretreatment for a renewable feedstock comprising organic nitrogen impurities prior to feeding said feedstock into catalytic hydrotreating and isomerisation. Removal of nitrogen impurities...
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WO/2023/032346A1 |
The present invention provides: porous particles each having a controlled three-dimensional network skeleton and communicating pores that are formed of voids of the skeleton, the communicating pores penetrating each porous particle from ...
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WO/2023/034810A1 |
Disclosed herein are fusion peptides comprising a fluorescent domain and a rare earth element detection domain capable of binding to a rare earth element and fluorescing when exposed to light when a rare earth element is bound and compos...
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WO/2023/034859A1 |
Disclosed herein are continuous reaction systems comprising a reaction vessel defining an interior volume and containing a plurality of inert scaffold particles. The reaction vessel can comprise an inlet line to provide one or more react...
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WO/2023/025906A1 |
Depth filtration media for the harvest clarification of a feed stream from cell cultures containing a therapeutic biomolecule. The depth filtration media is comprised of a sintered mixture of a polymeric adsorbent and a thermoplastic bin...
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WO/2023/027331A1 |
A micro-separator for gas chromatography comprises: a base substrate having a trench defining a microcolumn; and a three-dimensional porous ceramic-polymer composite which is disposed in the microcolumn and has periodically arranged thre...
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WO/2023/027044A1 |
The purpose of the present invention is to provide a method that enables effective and easy reduction of the amount of endotoxin in a liquid. A method for reducing the amount of endotoxin in a liquid according to the present invention is...
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WO/2023/022213A1 |
[Problem] To enable providing of, in a method for producing highly pure everolimus, a low cost purification step which enables efficient acquisition of highly pure everolimus from crude everolimus, and of which the safety has been confir...
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WO/2023/283006A9 |
A mechanically reinforced anion exchange membrane incorporates a functional polymer based on a poly(phenylene) backbone with quaternary ammonium functional groups and an inert porous scaffold material for reinforcement. The anion exchang...
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WO/2023/023032A1 |
A chromatographic bed insert includes a base having openings and an array of projection members positioned on the base and projecting substantially perpendicular to the base. The chromatographic bed insert has a displacement volume %D wh...
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WO/2023/023330A1 |
A novel adsorbent and contactor material based on polymer functionalized with amidoxime and alkylamines moieties. Methods of making the material are also described. The material can be easily processed into any desired sorbent geometry s...
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WO/2023/023541A1 |
Provided are methods of separating full capsid particles and empty capsid particles in a viral capsid preparation using an anion exchange medium. Methods may involve using a wash solution comprising a quaternary ammonium salt. Methods in...
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WO/2023/019184A1 |
Provided herein are processes for recovering lithium ions from a brine source. The process can comprises increasing the pH of a brine source comprising lithium ions to at least about 5.5; contacting the pH-elevated brine source with a be...
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WO/2023/017126A1 |
The present invention relates to a method for separating an analyte from a liquid mixture, said method comprises the steps of (i) providing at least one chromatographic support, wherein the at least one chromatographic support comprises ...
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