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WO/2022/081775A1 |
Provided herein are affinity ligands that specifically interact with AAV8 capsid and/or AAV8 variant capsid, affinity agents comprising the affinity ligands, and methods of their use for binding, isolation, and/or purification of AAV8 an...
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WO/2022/076956A1 |
A method for crystallization of cannabinoids includes: providing a substantially pure cannabinoid isolate; dissolving the cannabinoid isolate in a crystallization solvent; removing solvent by evaporation until the solution reaches satura...
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WO/2022/073121A1 |
An injection module having an injection valve and a restriction tubing permitting fluid flow from the injection valve to a column. The injection valve having a sample inlet port, a mobile phase inlet port, a waste port, a column port and...
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WO/2022/073995A1 |
A method is disclosed for manufacturing a purified pDNA preparation from a sample comprising pDNA and a contaminant, the method comprising the steps of: - Contacting the sample with a hydrophobic interaction chromatography (HIC) material...
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WO/2022/068023A1 |
A liquid separation kit. Using a conduction control element (168) on a tube (12), a user can selectively control the isolation or communication of a first chamber (122) and the outside of the tube (12) and the communication of the first ...
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WO/2022/072291A1 |
The invention relates to high molarity buffer elution from cation exchange chromatography for removal of product-related impurities during manufacture of recombinant multispecific proteins.
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WO/2022/072899A1 |
The present application provides methods and systems for viral clearance for purifying an antibody from a sample comprising one or more impurities including viral particles. The method is conducted in a system which includes a hydrophobi...
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WO/2022/072998A1 |
A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fl...
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WO/2022/072999A1 |
A process for removing Pb2+, Hg2+, K+ and NH4 + toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and...
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WO/2022/072213A1 |
A chromatography column includes a first flow distributor, a second flow distributor, and a media chamber having an inlet and an outlet. The second flow distributor is different from the first flow distributor. The first flow distributor...
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WO/2022/066928A2 |
The present disclosure relates to methods for preparing extracellular vesicles (EVs). In particular, the methods provided herein comprise contacting a sample, which comprises EVs and one or more impurities, with a depth filter, wherein t...
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WO/2022/059683A1 |
Provided is a method by which the monofunctional body, bifunctional body, etc. of a fluorine-containing ether compound having a polyfluoropolyether chain and a predetermined functional group can be separated with excellent yield and a hi...
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WO/2022/061026A1 |
The present disclosure is directed to stationary phase materials (e.g., porous inorganic-organic hybrid particles) for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylen...
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WO/2022/058857A1 |
The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample incl...
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WO/2022/061039A1 |
The present disclosure is directed to stationary phase materials for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylene glycol surface modified silica particle stationa...
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WO/2022/058856A1 |
The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a ch...
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WO/2022/061035A1 |
The present disclosure is directed to methods for performing size exclusion chromatography. Embodiments of the present disclosure feature methods for improving separations of proteinaceous analytes in size exclusion chromatography, for e...
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WO/2022/056466A1 |
Provided herein are, inter alia, biological manufacturing and downstream purification processes.
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WO/2022/055386A1 |
The invention relates to the field of separating rare earth elements by chromatography. The claimed method for separating lutetium and ytterbium from acidic solutions resulting from the recycling of irradiated ytterbium-176 targets is ca...
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WO/2022/056332A1 |
Affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3 are disclosed...
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WO/2022/056331A1 |
The present disclosure is directed to affinity chromatography devices including a fibrillated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or eq...
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WO/2022/048715A1 |
The invention relates to a Luer column (2, 34) having an inlet end (6), an outlet portion (8) spaced apart therefrom, and a housing casing (4) extending from the inlet end (6) to the outlet portion (8), the outlet portion (8) extending i...
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WO/2022/050271A1 |
This method for regenerating a liquid to be treated comprises bringing a lactic acid adsorbent 4, which contains a Mg-Al-based layered double hydroxide containing Mg2+ and Al3+ as constituent metals, and an ammonia adsorbent 5, which con...
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WO/2022/047310A1 |
Tangential flow filtration (TFF) is a size-based separation method conventionally used for buffer exchange, concentration, pathogen removal, and for coarse purification. Disclosed herein, TFF was used for selective purification of protei...
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WO/2022/039112A1 |
These absorbent particles include a carrier particle which comprises an organic polymer that includes monomer units derived from a styrene-base monomer, an organic compound which is attached to the surface of the carrier particle and whi...
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WO/2022/038190A1 |
A method for removal of host cell DNA from a sample containing a species of desired protein, virus, or extracellular vesicle comprising the steps of: - Loading a substrate bearing an anionic metal affinity ligand with a metal ion, - Equi...
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WO/2022/038164A1 |
A method for separating full Adeno-associated virus (AAV) capsids from empty AAV capsids in a buffered mixture comprising full AAV capsids, empty AAV capsids, comprising the steps of - contacting the buffered mixture with a first substra...
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WO/2022/034078A1 |
The present invention is in the technical field of cell cultivation or fermentation for the production of oligosaccharides. The present application discloses a method to produce a purified mixture of different oligosaccharides produced b...
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WO/2022/034079A2 |
The present invention is in the technical field of cell cultivation or fermentation for the production of oligosaccharides. The present application discloses a process for purification of an oligosaccharide solution produced by microbial...
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WO/2022/035326A1 |
The invention relates to processing methods to produce Bee Product Extracts produced from a Bee Product such as honey, pollen, waxes, or royal jelly; and in particular a Bee Product Extract produced from purifying manuka honey with catio...
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WO/2022/030593A1 |
Provided is an adsorption method for one or more elements belonging to the fourth to sixth periods and Groups 3-15 of the periodic table. This method includes: preparing mesoporous alumina satisfying at least one of (1) to have a surface...
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WO/2022/031359A1 |
Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chro...
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WO/2022/021541A1 |
Provided is an immunoglobulin binding protein prepared by joining E-, C-, and Z-domains of staphylococcal protein A to obtain increased antibody load and alkali resistance. The immunoglobulin binding protein can be used for affinity chro...
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WO/2022/023431A1 |
A process for the purification of Prothrombin Complex Concentrate (PCC) from complete plasma or cryo-poor plasma, in particular undiluted cryo-poor plasma, by means of chromatography using a monolithic stationary phase, the method compri...
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WO/2022/018906A1 |
Provided is a device for removing fine particles from a solvent containing fine particles, the device having: a fine-particle removal filter loaded with a fine-particle adsorbent having a charged functional group; a solvent line that sup...
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WO/2022/020743A1 |
Various aspects of this patent document relate to compositions and methods to purify cannabinoids from impurities by crystallization without the use of alkanes.
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WO/2022/015779A1 |
This disclosure relates to a process which involves: (a) providing an aqueous solution of a protein and a polyalkoxy fatty acyl surfactant of general formula I (I) wherein R1-C(=O) is a fatty acyl group, R2 is H or a substituted or unsub...
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WO/2022/013518A1 |
A method for separating at least two metals from each other in a metal refining process, the method comprising: injecting a feed solution comprising the metals into a column or flow pipe comprising a monolithic solid body having a plural...
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WO/2022/015801A1 |
The present disclosure relates to kits and methods that may be used for removal of matrix components, including proteins and lipids, from one or more oligonucleotides. The method comprises loading a sample comprising one or more target o...
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WO/2022/011785A1 |
Disclosed in the present utility model is a domestic sewage filtering device, comprising a transverse plate, wherein the left side of the top of the transverse plate is fixedly connected to a box body; the top of the transverse plate is ...
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WO/2022/008846A1 |
The present invention relates to a method for purifying an aromatic liquid compound comprising at least one step in which said aromatic liquid compound is brought into contact with a zeolitic adsorbent material. The present invention als...
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WO/2022/007811A1 |
The present invention relates to the technical field of adsorption-based lithium extraction devices, and provides a device extracting lithium from brine by using an adsorption method. The device comprises a belt-type vacuum filter; the b...
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WO/2022/007704A1 |
A zearalenone functionalized graphene surface molecularly imprinted material, a preparation method therefor and the use thereof, which belong to the technical field of molecularly imprinted materials. The zearalenone functionalized graph...
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WO/2022/005950A1 |
A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dime...
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WO/2022/006126A1 |
In one aspect, a method for automated analysis of samples from a bioreactor is provided herein, the method including: drawing at least one sample from a bioreactor; pressurizing the drawn at least one sample into a sample flow; purifying...
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WO/2022/006130A1 |
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The firs...
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WO/2022/003307A1 |
The present disclosure relates to a method for manufacturing multi-capillary lining that can serve as a chromatographic column, and to the multi-capillary packing obtained by such a method.
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WO/2022/000060A1 |
The present invention falls within the field of industrial biotechnology, more precisely the area of production and purification processes and describes a continuous process for purifying xylitol produced by fermentation. The process all...
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WO/2022/003482A1 |
Disclosed is a sampling unit (40) comprises a needle (200) configured for aspirating a sample fluid, a housing (365), and a fitting (370). The needle (200) comprises a needle tip (300) and a needle channel (310) through the needle (200) ...
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WO/2021/259850A1 |
The invention relates to a fraction collector apparatus (100) comprising: a support system (1, 2), a carrier (42) moveably supported by the support system (1, 2), an extension arm (3) connected to the carrier (42), at least one dispensin...
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