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WO/2024/094637A1 |
The present invention relates to a process for the preparation of cyclobutenone derivatives of formula (1), wherein Y is O or NH, R is -C(O)-R1 or -S(0)2-R1, and R' is selected from optionally substituted linear or branched C1-12 alkyl, ...
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WO/2024/092892A1 |
Provided are an edoxaban intermediate and a preparation method therefor. Specifically, the edoxaban intermediate includes intermediate compounds of formula I and formula II. The preparation method comprises: subjecting a compound of form...
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WO/2024/089666A1 |
An efficient, economical and continuous process for the preparation of L-lysine-D- amphetamine dimesylate.
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WO/2024/071178A1 |
Provided is an industrially useful method for producing an alkylsilyloxy-substituted benzylamine compound, in which impurities are easily removed and the method does not involve an alkylsilyloxy-substituted benzyl compound that is an int...
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WO/2024/068685A1 |
The invention relates to a process for producing phosgene, especially for the reaction of phosgene with organic amino compound to give organic isocyanate. In this process, at least one carbon dioxide gas stream that has been formed from ...
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WO/2024/070222A1 |
A carbon dioxide supply conversion agent according to the present invention is for carbon dioxide to be used for a reaction with an alkylamine compound, and comprises an oxide and carbon dioxide adsorbed on the surface of the oxide.
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WO/2024/053350A1 |
The purpose of the present invention is to provide a method for producing an aminoazide compound and a diamine compound in which the formation of undesired diastereomers is inhibited and which has good diastereoselectivity. Provided is a...
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WO/2024/024965A1 |
The present invention addresses the problem of providing a method for producing an O-substituted serine derivative, which makes it possible to produce an O-substituted serine derivative in fewer steps. The present inventors have made ext...
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WO/2024/011415A1 |
Disclosed in the present invention is a method for preparing an o-iodophenyl compound, wherein an iodobenzene compound and an amide compound as raw materials are reacted in the presence of sodium hydride or n-butyllithium and a solvent t...
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WO/2023/280638A9 |
The application relates to vinyl thianthrenium compounds Vinyl- TT+X- of the Formula (I), a process for preparing the same and the use thereof for vinylating organic compounds.
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WO/2024/007851A1 |
A catalyst for amide synthesis and preparation and use thereof are disclosed. The catalyst is a thio or seleno pyranodipyrimidine compound and has a simple and novel structure, high catalytic efficiency, and good atom economy. The cataly...
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WO/2023/236976A1 |
A lipid compound and a preparation method therefor, and a use thereof. The lipid compound is safe, efficient and ionizable, and the structure of the lipid compound is divided into a hydrophilic amino group, a linking group, and a hydroph...
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WO/2023/219152A1 |
One aspect of the present invention relates to a method for producing a salt of an amino acid, a salt of a peptide compound, or a solvate of either one of the salts, the method comprising the following steps (A) and (B). Step (A): a st...
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WO/2023/206874A1 |
A sacubitril intermediate, a preparation method therefor, and use thereof. A key intermediate N-Boc amino alcohol represented by formula (10) or formula (10-a) can be efficiently prepared. The intermediate can be used to prepare a neutra...
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WO/2023/200913A1 |
Described herein are methods of synthesizing 5-chloro-2-((ethoxycarbonyl)amino)-3- methylbenzoic acid and derivatives thereof.
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WO/2023/179462A1 |
Disclosed in the present invention are a cationic lipid compound, a preparation method therefor and the use thereof, and an mRNA delivery system, which solve the problem of there being an urgent need to develop cationic lipids with high ...
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WO/2023/175492A1 |
The present invention relates to novel intermediate of formula (V) and formula (VI) and preparation thereof. The present invention further relates to an industrially feasible and commercially viable process for preparation of sitagliptin...
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WO/2023/168889A1 |
Disclosed herein are a preparation method for an alicyclic carbamate and the use thereof. The preparation method comprises the following steps: mixing a carbamate containing an aromatic ring, a catalyst and a solvent, and then introducin...
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WO/2023/164889A1 |
Disclosed are a method for preparing codeine and a derivative and intermediate thereof. Simple, cheap and easily-available commercially available compounds are used as starting materials in the present invention, various intermediates th...
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WO/2023/158634A1 |
Described herein are crystalline forms of a prostacyclin (IP) receptor agonist compound, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatm...
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WO/2023/143158A1 |
The present invention relates to a phenol derivative, a crystal form thereof, and a preparation method therefor, in particular to a solid intermediate used for preparing the phenol derivative, and specifically provides a compound shown i...
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WO/2023/134673A1 |
A high-selectivity KCNQ4 potassium channel agonist of formula I, a preparation method therefor and the use thereof. The compound further improves the KCNQ4 agonistic activity, and is still free of KCNQ2 agonistic activity, thus having ex...
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WO/2023/123747A1 |
The present invention relates to the technical field of photoinitiator synthesis, and in particular relates to a hydrogen abstraction photoinitiator, a preparation method therefor, and a use thereof. The hydrogen abstraction photoinitiat...
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WO/2023/106377A1 |
Provided is a method for producing a blocked isocyanate compound, the method comprising a reaction step of reacting a primary amine compound, a carbonic acid derivative, and a blocking agent by means of heat treatment in the presence of ...
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WO/2023/080257A1 |
The method for producing isocyanate compounds comprises: a step (1) for obtaining an N-substituted carbamate compound by reacting a primary amine compound and a carbonate derivative, while removing by-product compounds that have a boilin...
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WO/2023/080258A1 |
The present invention provides a carbonyl compound represented by general formula (I) (wherein R11 is an (n11+n12)-valent organic group, R12 is a monovalent organic group, n11 is an integer of 1-8, n12 is an integer of 0-7, and the sum o...
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WO/2023/071328A1 |
Disclosed is a method for synthesizing 8-amino-1-{[2-(trimethylsilyl)ethoxy]methoxy}octane-3-one, which belongs to the technical field of pharmaceutical chemical synthesis. The method comprises the steps of: firstly, protecting diphenylm...
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WO/2023/073606A1 |
The present invention relates to an industrially feasible and economically viable process for preparation of Edoxaban key intermediate viz. compound of formula (1) which is shown below:
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WO/2023/072143A1 |
Disclosed in the present invention are a camptothecin derivative intermediate, and a preparation method therefor and the use thereof. The structural formula of the camptothecin derivative intermediate of the present invention is as shown...
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WO/2023/065610A1 |
The present invention relates to the field of drug synthesis. Disclosed is a preparation method for halofuginone intermediate trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-aceton
e. The preparation method of the present invention...
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WO/2023/029235A1 |
The present invention belongs to the technical field of chemical synthesis and discloses a method for preparing a sacubitril intermediate. A key aza-tricyclic compound 5 is generated by using starting materials, chloramine-T trihydrate (...
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WO/2023/033015A1 |
Provided is a method for producing a Fmoc-protected amino group-containing compound, wherein a raw material amino group-containing compound is not wasted, by-production of Fmoc-β-Ala-OH is suppressed, and the purification of a target su...
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WO/2023/017474A1 |
This invention provides a flow synthesis process for producing sulfonylurea compounds of formula (1), including gliclazide, chlorpropamide and tolbutamide, and pharmaceutically acceptable salts thereof.
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WO/2023/014160A1 |
The present invention relates to a crystalline form of a phenyl carbamate derivative compound and uses thereof, and more specifically, the present invention relates to a pattern 1 crystalline form, which is a thermodynamically more stabl...
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WO/2023/004687A1 |
Provided by the present invention is an unnatural amino acid, which is a compound having a structure as shown in formula (I) or an enantiomer thereof. Further provided by the present invention is an application of the unnatural amino aci...
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WO/2023/286053A1 |
The present invention pertains to a process for preparing of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I as intermediate in the preparation of arthropodicidal indoxacarb, comprising reaction of compound of formu...
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WO/2023/285310A1 |
The invention relates to novel carbodiimides, to a process for the preparation and use thereof as a stabilizer in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene terephthalate (PBT), in polytrimethylene terephth...
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WO/2022/264168A1 |
The present invention provides a process for preparation of compound of formula (I), a key intermediate in synthesis of L-glufosinate or its salt. wherein P2 is an amino-protecting group; R1 is hydrogen, substituted or unsubstituted C 1 ...
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WO/2022/246929A1 |
The present invention relates to the technical field of drug synthesis, and provides a preparation method for an ABT-737 key intermediate and a preparation method for ABT-737. A compound having a structure as represented by formula I is ...
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WO/2022/041171A9 |
The present application relates to a compound having the effects of being an antidepressant, narcotizing, alleviating pain, improving cognitive functions, protecting lungs, preventing or treating amyotrophic lateral sclerosis, or prevent...
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WO/2022/201155A1 |
The present invention relates to a novel nitration process of 2- chloro -4- fluorobenzoic acid to 2-chloro-4- fluoro-5-nitrobenzoic acid, 2-chloro-4- f luoro-3 -nitrobenzoic acid and 3, 5-dinitro-2-chloro-4- fluorobenzoic acid; purifying...
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WO/2022/197182A1 |
The present invention pertains to improved methods for preparing cyclooctenes and conjugates thereof. In particular, methods for regioselective modification and/or enantiomerically enriching compounds are disclosed. In addition, compound...
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WO/2022/190486A1 |
The present invention provides, as a novel compound that can be utilized for efficient synthesis or the like of a polypeptide comprising various amino acids, a silane-containing condensed cyclic dipeptide compound represented by formula ...
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WO/2022/169729A1 |
A crosslinkable coating composition comprising: ingredient A that has at least two protons that can be activated to form a Michael carb anion donor, wherein ingredient A is selected from the group consisting of an acetoacetate group cont...
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WO/2022/148585A1 |
The present invention relates to a method for producing materials having at least one carbamate functionality, to carbamate-functional materials obtained from the inventive process, coating compositions comprising said carbamate-function...
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WO/2022/138891A1 |
The present invention addresses the problem of providing a method for producing a high-purity peptide compound with high efficiency and high yield. It is found that the problem can be solved by supporting a peptide on a resin for solid-p...
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WO/2022/138605A1 |
The present invention addresses the problem of providing a method for efficiently producing a peptide having a high purity, a reagent for forming a protective group having excellent deprotection properties, and a novel fused polycyclic c...
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WO/2022/134297A1 |
The present invention relates to a preparation method for a carboxylate ester compound, comprising: under the catalysis of a nitrite ester, reacting carboxylic acid and methanol in air, so as to obtain an ester compound. The preparation ...
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WO/2022/112868A1 |
The subject matter of the invention is a method for the preparation of oligocarbamates with a defined monomeric sequence of the general formula (I) characterised in that the multistage synthesis is performed in one reaction pot without t...
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WO/2022/084834A1 |
The present invention concerns a novel process for preparing solriamfetol hydrochloride.
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