Title:
METHOD FOR PREPARING O-IODOPHENYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/011415
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for preparing an o-iodophenyl compound, wherein an iodobenzene compound and an amide compound as raw materials are reacted in the presence of sodium hydride or n-butyllithium and a solvent to obtain the o-iodophenyl compound. With the deepening of organic chemistry in every aspect of people's lives, it is crucial to explore a green and environmentally-friendly, convenient and quick synthesis method with high atom utilization rate, whether in the research and development of drug synthesis processes or in other aspects such as industrial manufacturing. The compound containing a C-N bond is not only widely present in the natural world, but also plays an irreplaceable role in the field of biomedicine. The present invention introduces a new method for efficiently constructing a C-N bond by using o-diiodobenzene as a precursor without a metal catalyst and an expensive special ligand thereof and conditions such as high temperature and high pressure.
Inventors:
ZHANG SHILEI (CN)
JIANG YUANRUI (CN)
ZHU WENJING (CN)
HU YANWEI (CN)
JIANG YUANRUI (CN)
ZHU WENJING (CN)
HU YANWEI (CN)
Application Number:
PCT/CN2022/105231
Publication Date:
January 18, 2024
Filing Date:
July 12, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07B43/06; C07C231/12; C07C233/15; C07C233/59; C07C233/66; C07C235/24; C07C269/06; C07C271/14; C07C271/16; C07C319/02; C07C323/43; C07D207/14; C07D209/42; C07D211/58; C07D213/64; C07D213/75; C07D215/227; C07D235/26; C07D263/38; C07D277/48; C07D277/62; C07D295/32; C07D307/52; C07D307/68; C07D319/08; C07D319/18; C07D333/36; C07D333/38
Foreign References:
| CN113620848A | 2021-11-09 | |||
| CN1518534A | 2004-08-04 | |||
| CN105218449A | 2016-01-06 | |||
| CN1257484A | 2000-06-21 |
Other References:
ABEL-SNAPE XAVIER, WHYTE ANDREW, LAUTENS MARK: "Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 20, 16 October 2020 (2020-10-16), US , pages 7920 - 7925, XP093127750, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c02850
KLAPARS A, HUANG X, BUCHWALD S L: "A General and Efficient Copper Catalyst for the Amidation of Aryl Halides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, 1 January 2002 (2002-01-01), pages 7421 - 7428, XP002331140, ISSN: 0002-7863, DOI: 10.1021/ja0260465
AL-ZOUBI RAED M., AL-JAMMAL WALID K., AL-ZOUBI MAZHAR S., MCDONALD ROBERT, ZAROUR AHMAD, YASSIN AKSAM, AL-ANSARI ABDULLA: "Copper(I)-catalyzed regioselective Ullmann-type coupling of primary carbamates and 5-substituted-1, 2, 3-triiodobenzenes: facile synthesis of 2, 3-diiodinated N-aryl carbamates", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 45, no. 19, 17 May 2021 (2021-05-17), GB , pages 8432 - 8439, XP093127755, ISSN: 1144-0546, DOI: 10.1039/D1NJ01332G
KLAPARS A, HUANG X, BUCHWALD S L: "A General and Efficient Copper Catalyst for the Amidation of Aryl Halides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, 1 January 2002 (2002-01-01), pages 7421 - 7428, XP002331140, ISSN: 0002-7863, DOI: 10.1021/ja0260465
AL-ZOUBI RAED M., AL-JAMMAL WALID K., AL-ZOUBI MAZHAR S., MCDONALD ROBERT, ZAROUR AHMAD, YASSIN AKSAM, AL-ANSARI ABDULLA: "Copper(I)-catalyzed regioselective Ullmann-type coupling of primary carbamates and 5-substituted-1, 2, 3-triiodobenzenes: facile synthesis of 2, 3-diiodinated N-aryl carbamates", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 45, no. 19, 17 May 2021 (2021-05-17), GB , pages 8432 - 8439, XP093127755, ISSN: 1144-0546, DOI: 10.1039/D1NJ01332G
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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