Title:
HIGH-SELECTIVITY KCNQ4 POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/134673
Kind Code:
A1
Abstract:
A high-selectivity KCNQ4 potassium channel agonist of formula I, a preparation method therefor and the use thereof. The compound further improves the KCNQ4 agonistic activity, and is still free of KCNQ2 agonistic activity, thus having excellent KCNQ4/KCNQ2 selectivity. The high-selectivity KCNQ4 agonist overcomes the defect of poor selectivity of existing potassium channel agonists, the activity is relatively increased, and the toxicity is remarkably reduced. The agonist also has a simpler structure and lower product cost, thereby having a better development prospect.
Inventors:
NAN FAJUN (CN)
GAO ZHAOBING (CN)
DONG WUHENG (CN)
ZHENG YUEMING (CN)
WANG JINTAO (CN)
ZHOU XIAOYU (CN)
LIU HUANAN (CN)
XU HAIYAN (CN)
GAO ZHAOBING (CN)
DONG WUHENG (CN)
ZHENG YUEMING (CN)
WANG JINTAO (CN)
ZHOU XIAOYU (CN)
LIU HUANAN (CN)
XU HAIYAN (CN)
Application Number:
PCT/CN2023/071587
Publication Date:
July 20, 2023
Filing Date:
January 10, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07C271/28; A61K31/27; A61K31/277; A61P1/14; A61P9/12; A61P11/00; A61P11/06; A61P13/10; A61P15/00; A61P17/04; A61P19/00; A61P25/00; A61P27/16; C07C269/04; C07C269/06
Foreign References:
| CN103073455A | 2013-05-01 | |||
| CN105017085A | 2015-11-04 | |||
| CN109641836A | 2019-04-16 |
Other References:
WANG LEI, QIAO GUAN-HUA, HU HAI-NING, GAO ZHAO-BING, NAN FA-JUN: "Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 1, 10 January 2019 (2019-01-10), US , pages 27 - 33, XP093078760, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00315
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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