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WO/2023/097308A1 |
Embodiments of the present application relate to the preparation of 2'-O-protected nucleoside phosphoramidites and conjugation of the 2'-O-protected nucleoside to a solid support. More specifically, the present application relates to nuc...
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WO/2023/093722A1 |
The present application relates to a compound having a structure shown in formula (I), wherein n1 is an integer selected from 4-21, and n2 is an integer selected from 1-2. The present invention also relates to a composition, comprising a...
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WO/2023/093337A1 |
The present invention discloses a genetically engineered bacteria, which is E. coli integrated with lysogenic λDE3, and lacZ gene is completely inactivated, but does not affect exogenous protein expression of the genetically engineered ...
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WO/2023/082574A1 |
The present invention provides a method for synthesizing selamectin, specifically comprising: oxidizing doramectin by means of manganese dioxide, oximating and desugaring same by using a hydroxylamine hydrochloride aqueous solution in a ...
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WO/2023/077503A1 |
A method for increasing the bulk density of a crystal of nicotinamide mononucleotide (NMN), and a crystal of NMN. The method comprises: dissolving NMN in water to obtain an aqueous solution of NMN; subjecting the aqueous solution of NMN ...
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WO/2023/078551A1 |
The present invention relates to a method for producing a plant extract comprising phyllodulcin, a plant extract obtained or obtainable by such a method, a flavouring mixture comprising such a plant extract, a composition comprising such...
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WO/2023/079021A1 |
The present invention relates to a method for producing a plant extract comprising phyllodulcin, a plant extract obtained or obtainable by such a method, a flavouring mixture comprising such a plant extract, a composition comprising such...
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WO/2023/072085A1 |
The present invention relates to an isopropyl-D-glucopyranoside derivative and a synthesis method therefor. In addition, the derivative can effectively promote the regeneration of cranial nerves and retinal nerves and repair the damage o...
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WO/2023/072890A1 |
The present invention refers to a process for preparing sucrose octasulfate octakistriethylammonium salt (TASOS) powder, comprising the steps of combining a TASOS solution with a polar organic solvent(s) and triethylamine, thereby obtain...
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WO/2023/074843A1 |
[Problem] The problem of the present invention is to provide: a novel oligosaccharide that can be used in order to manufacture a 2-branched glycan having an α2,6-sialic acid structure at a non-reducing end; a method for manufacturing th...
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WO/2023/071293A1 |
Disclosed in the present application is a method for preparing molnupiravir, which belongs to the technical field of drug preparation. The preparation method comprises the following steps: (1) adding the compound of formula (I) to an alc...
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WO/2023/067121A1 |
The present disclosure provides a compound of formula I, as well as complexes and compositions comprising a compound of formula I, wherein said compositions and complexes are useful for delivery of certain agents, including, for example,...
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WO/2023/067124A1 |
The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.
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WO/2023/065683A1 |
Disclosed are a novel deuterated purine nucleoside compound as shown in formula I, or a pharmaceutically acceptable salt, an isomer, or a prodrug thereof. Also disclosed are a preparation method for said deuterated compound, a compositio...
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WO/2023/065427A1 |
The present invention relates to a glycoside compound, which is named as 2-propenyl guaethol-β-D-glucopyranoside, and has the following structural formula. The present invention further relates to a method for preparing the glycoside co...
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WO/2023/067126A1 |
The present disclosure provides compositions comprising an oligosaccharide of formula (I), wherein said compositions are useful for delivery of certain agents, including, for example, nucleic acids.
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WO/2023/062074A1 |
Disclosed is a process for preparing alkyl polyglycosides having a color of less than or equal to 1.5 VCS, the process successively involving: a) a glycosylation step a) consisting in a reaction between at least one alcohol of formula (I...
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WO/2023/064147A1 |
Through solid dosage minor reduction, the weight percentage of solids in an initial solution of crystallization is reduced in a controlled manner for crystallizing a stevia extract or remaining stevia extract starting material with low s...
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WO/2023/063364A1 |
The purpose of the present invention is to provide a technology useful for sugar synthesis, the technology using formaldehyde as the main raw material and allowing for selective promotion of the formose reaction. This method for produc...
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WO/2023/062078A1 |
Disclosed is a process for preparing alkyl polyglycosides having a color of less than or equal to 1.5 VCS, the process successively involving: a) a glycosylation step a) consisting in a reaction between at least one alcohol of formula (I...
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WO/2023/062077A1 |
Disclosed is a process for preparing alkyl polyglycosides having a color of less than or equal to 1.5 VCS, the method successively comprising: (a) a glycosylation step (a), consisting in a reaction between at least one alcohol of formula...
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WO/2023/060021A1 |
CD33 ligands which are useful for the synthesis of CD33 ligand-bearing carriers, wherein said CD33 ligand-bearing carriers are directly or indirectly linked to or associated with at least one anti-cancer agent, are described herein. Uses...
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WO/2023/047141A1 |
Provided herein are analogues of S-adenosyl-L-methionine, methods of their preparation, and complexes and kits comprising the analogues. Said analogues find use in modifying, labelling and analysing a target molecule such as a nucleic acid.
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WO/2023/045036A1 |
An mRNA delivery system and a preparation method therefor and an application thereof. The mRNA delivery system comprises a vector and mRNA loaded on the vector. The vector comprises a lipid-like nanoparticle containing a quaternary ammon...
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WO/2023/035479A1 |
Disclosed is a traditional Chinese medicine composite which has the effect of promoting directional differentiation of stem cells into cardiomyocytes, comprising: syngnathus, pilose antler, hippocampus, ginseng, astragalus membranaceus, ...
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WO/2023/036932A1 |
The present invention relates to a glycocluster comprising at least two acetylated-sialic acids covalently linked to a macrocycle, wherein said macrocycle is selected from porphyrins, pillararenes, calixarenes and fullerenes. According t...
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WO/2023/031481A1 |
The present invention relates to a method for preparing cyclic guanosine-3', 5'- monophosphate analogues. The invention also relates to the new cyclic guanosine-monophosphate analogues and intermediates obtained by the method.
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WO/2023/025073A1 |
Disclosed in the present invention are a capped analog and the use thereof. The capped analog has a structure as shown in formula (I):
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WO/2023/021286A2 |
The present invention relates to novel nucleotide complexes which enhance the enzymatic production of DNA. The nucleotide complexes includes a divalent cation at a ratio of 0.2-1.5 divalent cations per nucleotide, whilst monovalent ions ...
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WO/2023/018326A1 |
Provided are compounds of formula (I) and (II), which are useful as surfactants. Also provided are methods of preparing compounds of formula (I) and (II).
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WO/2023/010323A1 |
Provided is a method for preparing sucralose. The method comprises the steps of: feeding a chlorination reaction solution for preparing sucralose-6 ester, a first liquid alkali and first reuse water into a neutralization reaction rectify...
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WO/2023/014952A1 |
Compositions comprising a sugar alkoxylate and processes for preparing said compositions are provided. The compositions can be used as a bio-film inhibitor, rheology modifier, emulsion breaker, and/or emulsion inverter. Additionally, the...
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WO/2023/000516A1 |
The present invention provides a purification method for paeoniflorin-6-O'-benzene sulfonate. According to the purification method, the purification process for paeoniflorin-6-O'-benzene sulfonate can be reduced, and impurities, such as ...
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WO/2023/002354A1 |
The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase ...
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WO/2023/000517A1 |
Provided in the present invention is a method for preparing paeoniflorin-6-O'-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial ...
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WO/2023/002452A1 |
The present application provides synthetic processes for preparing N-acetyl-galactosamines (NAG) based compounds for targeted drug delivery. Also disclosed are Poly-NAG compounds, intermediates and targeting ligands, which are used and/o...
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WO/2023/000518A1 |
Provided in the present invention is a method for synthesizing a paeoniflorin derivative of formula III. The synthesis method can obviously reduce the use amount of a reaction solvent, shortens the reaction time, has the characteristics ...
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WO/2023/001004A1 |
The present invention relates to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine, and in particular to a mannose derivative and an application thereof. The mannose derivative is an isonitrile-containin...
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WO/2023/000708A1 |
Disclosed are a polysubstituted purine compound as shown in formula (I), and a pharmaceutically acceptable salt thereof, a preparation method therefor and the use thereof. Also disclosed is that the compound has an obvious inhibitory eff...
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WO/2023/287557A1 |
This disclosure relates to a method and a system for processing grapes. An example system includes a simulated moving bed (SMB) device configured to receive a feed stream and an eluent stream as inputs and provide an extract stream and a...
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WO/2023/285367A1 |
The present invention provides the use of a separation process to obtain a product composition comprising at least one sophorolipid, wherein the product composition achieves a negative result under the h-CLAT assay according to OECD 442E...
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WO/2023/279276A1 |
The present application provides a method for purifying sucralose-6-ester. The method comprises: adding an oxidizing agent to a mother solution to be purified, carrying out an oxidation reaction under a first preset condition, then addin...
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WO/2023/280857A1 |
Disclosed is a process preparing diosmin and flavonoid fraction by direct oxidation of hesperidin.
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WO/2023/279278A1 |
The present application provides a method for purifying sucralose-6-ester, comprising: a concentration step: concentrating a mother liquor to be purified so as to remove an organic solvent, and adding water after concentration is complet...
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WO/2023/280257A1 |
The present invention belongs to the field of microbial fermentation, and specifically provides a pretreatment process for an acarbose fermentation liquid. By means of successively adding a filter aid twice, adjusting the pH with an acid...
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WO/2023/279277A1 |
The present application provides a method for preparing an organotin-sucrose complex, comprising: acylating a DMF solution of sucrose with an organotin ester catalyst under predetermined conditions to generate an organotin-sucrose comple...
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WO/2022/268235A1 |
The present invention relates to the technical field of plant extraction, and in particular relates to a saponin composition having high stability and a preparation method therefor. The saponin composition is extracted from natural plant...
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WO/2022/263718A1 |
The present invention relates to a method for producing cationic saccharide comprising providing a mixture comprising betaine aldehyde and a saccharide;allowing the betaine aldehyde to react with the saccharide; and obtaining cationic sa...
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WO/2022/258043A1 |
The present invention provides gemcitabine anticancer derivatives of formula (III) and the anticancer pharmaceutical use, which have the potential to be developed into AKR1C3-activated anticancer drugs.
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WO/2022/253234A1 |
The present invention relates to a crystal form I and crystal form II of the compound 2-N-4,6-di-O-tributyryl-D-glucosamine, and a preparation method therefor and the use thereof. The crystal form I and crystal form II obtained in the pr...
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