Title:
METHOD FOR SYNTHESIZING PAEONIFLORIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/000518
Kind Code:
A1
Abstract:
Provided in the present invention is a method for synthesizing a paeoniflorin derivative of formula III. The synthesis method can obviously reduce the use amount of a reaction solvent, shortens the reaction time, has the characteristics of saving on cost, simple operation, mild conditions and greatly improved reaction yield, is suitable for a more extensive paeoniflorin structural modification, and can meet the needs of industrialization.
Inventors:
TANG SHUNZHI (CN)
XU WENDONG (CN)
YUAN CHENG (CN)
FU YUPING (CN)
PENG WANCAI (CN)
BAI BAI (CN)
LI SONGTAO (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
CHEN WEN (CN)
LI JIALI (CN)
LI YAO (CN)
MAO YUKANG (CN)
XU WENDONG (CN)
YUAN CHENG (CN)
FU YUPING (CN)
PENG WANCAI (CN)
BAI BAI (CN)
LI SONGTAO (CN)
LI JIRONG (CN)
WEI SHAOHENG (CN)
CHEN WEN (CN)
LI JIALI (CN)
LI YAO (CN)
MAO YUKANG (CN)
Application Number:
PCT/CN2021/124537
Publication Date:
January 26, 2023
Filing Date:
October 19, 2021
Export Citation:
Assignee:
GUANGZHOU HANFANG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H1/00; A61K31/7048; A61P19/02; A61P29/00; C07H17/04
Foreign References:
| CN102603827A | 2012-07-25 | |||
| CN102643316A | 2012-08-22 | |||
| CN104098617A | 2014-10-15 | |||
| CN109481452A | 2019-03-19 |
Other References:
HARA ATSUSHI, IMAMURA AKIHIRO, ANDO HIROMUNE, ISHIDA HIDEHARU, KISO MAKOTO: "A New Chemical Approach to Human ABO Histo-Blood Group Type 2 Antigens", MOLECULES, vol. 19, no. 1, 31 December 2013 (2013-12-31), pages 414 - 437, XP093027371, DOI: 10.3390/molecules19010414
YOSHINORI TSUDA ,MAKOTO NISHIMURA ,TAKUYA KOBAYASHI ,YOSHIYUKI SATO ,KIMIHIRO KANEMITSU: "Regioselective Monotosylation of Non-protected and Partially Protected Glycosides by the Dibutyltin Oxide Method", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 39, no. 11, 26 November 1991 (1991-11-26), pages 2883 - 2887, XP093027383, ISSN: 0009-2363, DOI: 10.1248/cpb.39.2883
ZHAO LI-FANG ,WANG HONG-SHE,MIAO JIAN-YING: "Preparation of New Organotin Compounds and Their Application to Esterification Reaction", CHINESE JOURNAL OF APPLIED CHEMISTRY, vol. 23, no. 11, 10 November 2006 (2006-11-10), pages 1273 - 1277, XP093027387, ISSN: 1000-0518
YOSHINORI TSUDA ,MAKOTO NISHIMURA ,TAKUYA KOBAYASHI ,YOSHIYUKI SATO ,KIMIHIRO KANEMITSU: "Regioselective Monotosylation of Non-protected and Partially Protected Glycosides by the Dibutyltin Oxide Method", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 39, no. 11, 26 November 1991 (1991-11-26), pages 2883 - 2887, XP093027383, ISSN: 0009-2363, DOI: 10.1248/cpb.39.2883
ZHAO LI-FANG ,WANG HONG-SHE,MIAO JIAN-YING: "Preparation of New Organotin Compounds and Their Application to Esterification Reaction", CHINESE JOURNAL OF APPLIED CHEMISTRY, vol. 23, no. 11, 10 November 2006 (2006-11-10), pages 1273 - 1277, XP093027387, ISSN: 1000-0518
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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