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JP2015070856A |
To provide a yeast capable of conducting alcoholic fermentation and using xylose as a carbon source.The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable fr...
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JP2014087365A |
To provide a method of applying a chemically defined formulation in industrial scale fermentation, in order to avoid problems associated with a usual use method of a composite culture medium in the current industrial site.Use of a chemic...
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JP5295758B2 |
Disclosed is a novel process for producing a 1ß-methylcarbapenem compound by culturing a microorganism. A 1ß-methylcarbapenem compound can be produced by culturing a microorganism capable of producing a carbapenem compound, particularl...
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JP5261709B2 |
To provide a method for adding a fatty acid to an amino acid, a peptide and a protein by an enzymatic means, in an aqueous solution. This method for producing a fatty acid-added amino acid or fatty acid-added amino acid derivative, fatty...
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JP2013078345A |
To provide a new production method by culturing a microorganism of an 1β-methylcarbapenem based compound.A useful 1β-methylcarbapenem based compound as a medicine or a raw material for medicines by culturing a microorganism producing a...
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JP2012513196A |
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...
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JP4949826B2 |
The present invention relates to a product of amoxicillin trihydrate, having a free water content of less than 0.1 wt.%, preferably less than 0.07 wt.%, more preferably less than 0.05 wt.%, measured at an equilibrium relative humidity of...
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JP4949827B2 |
The present invention relates to a product of amoxicillin trihydrate, having a free water content of less than 0.1 wt.%, preferably less than 0.07 wt.%, more preferably less than 0.05 wt.%, measured at an equilibrium relative humidity of...
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JP2011152148A |
To provide a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for non-homologous recombination (NHR).There is provide...
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JP4469401B2 |
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...
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JP2010516800A |
The invention relates to novel antimicrobial agents that are based on β-lactam derivatives and are produced by reacting previously known β-lactam derivatives with polyphenol oxidase substrates under the influence of free radicals and b...
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JP2009195254A |
To apply a chemically defined treatment in an industrial scale fermentation in order to avoid problems associated with usual methods of using complex media in the present industrial scenes.The use of chemically defined media for fermenta...
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JP4217277B2 |
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...
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JP4147319B2 |
New mutant beta -lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G acylase and having an amino acid sequence...
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JP4080542B2 |
New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequen...
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JP2007530065A |
The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleot...
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JP2007525942A |
Methods are provided for the production and recovery of multifunctional aromatic compounds from a fermentation medium. Preferred multifunctional aromatic compounds include para-hydroxycinnamic acid (pHCA), cinnamic acid (CA), and para-hy...
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JP2007514800A |
A combinatorial lubricating oil composition library is provided including at least a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating viscosity and (b) at least one lubricatin...
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JP2007508022A |
The invention relates to isolated nucleic acid molecules, which code for a new protein of Penicillium chrysogenum, vectors which comprise a nucleic acid molecule of this kind, host cells which are transformed with such a nucleic acid mol...
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JP2006523447A |
New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed.
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JP3819429B2 |
A process for preparing an enzyme from Penicillium chrysogenum having Phenylacetate-Coenzyme A activity. DNA encoding for the enzyme is also provided and its use in the production of modified strains.
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JP3764166B2 |
PCT No. PCT/DK95/00386 Sec. 371 Date Mar. 5, 1997 Sec. 102(e) Date Mar. 5, 1997 PCT Filed Sep. 28, 1995 PCT Pub. No. WO96/10084 PCT Pub. Date Apr. 4, 1996The invention relates to an improved process for the production of a secondary meta...
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JPWO2003104446A1 |
The subject of the present invention is a highly active β-lactam acylase protein, a gene encoding the β-lactam acylase protein, a recombinant vector having the gene, a transformant containing the recombinant vector, and the β-lactam a...
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JP2004501619A |
A process for the preparation of biologically active compounds, wherein active substances having additional functional groups and a modified spectrum of activity and modified application properties are obtainable from medicinal substance...
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JP2003512832A |
The invention relates to organisms producing increased levels of clavulanic acid and other 5R clavams, including those with strong beta -lactamase inhibitory activity, in combination with low or undetectable levels of 5S clavams.
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JP2003512039A |
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for...
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JP2002316991A |
To provide the penicillin and cephalosporin causing no enzyme inhibition.The objective penicillin and cephalosporin includes phenylacetic acid or phenoxyacetic acid in an amount of ≤100 ppm.
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JP3321107B2 |
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved i...
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JP2001527381A |
A new immobilized Penicillin G acylase with a surprisingly good performance has been provided for. By applying this new immobilized enzyme, beta -lactam derivatives are prepared in high yield by enzymatic reaction of a parent amino beta ...
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JP2001526060A |
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the r...
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JP2001521396A |
The present invention discloses an improved process for the preparation of 6-amino penicillanic acid (6-APA) from a fermentatively produced N-substituted penicillin, comprising the steps of extraction of the N-substituted penicillin comp...
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JP2001515729A |
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic aci...
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JP2001506131A |
The present invention discloses a fermentative process for the production of penicillin G or V or cephalosporin G or V derivatives wherein certain derivatives of phenylbutyric acid are used as a side chain precursor. In said phenylbutyri...
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JP2000342289A |
To isolate a gene for biologically synthesizing penicillin by isolating a structure containing a gene encoding isopenicillin N synthetase, acyltransferase, ACV synthetase or the like and isolating another structure by a chromosome walkin...
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JP3115593B2 |
beta -Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta -lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta -lactam derivative in the ...
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JP2000516215A |
Disclosed is a process for the synthesis of beta -lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
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JP2000512860A |
The invention relates to a method for preparing a beta-lactam antibiotic, wherein an N-substituted beta-lactam, having general formula (I), wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; Z...
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JP3095391B2 |
Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the antibiotic. The invention is exemplified with...
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JP2000512512A |
The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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JP2000512513A |
Procedure for the inactivation of genes that code for phenylacetate catabolism enzymes, plasmids containing them, and strains transformed with them. The procedure is preferably applied to the phacA gene of A. nidulans and to the pahA gen...
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JP2000512511A |
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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JP2000509613A |
The invention relates to promoters of the genes glutamate dehydrogenase, beta-acetylhexosaminidase and gamma-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. The invention also relates to the u...
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JP3072101B2 |
(A) A novel process for preparing 7-aminodesacetoxy cephalsporanic acid (7-ADCA) is claimed comprising (a) maintaining in a culture medium capable of sustaining its growth, a strain of Penicillium chrysogenum (PC) which produces isopenic...
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JP3027847B2 |
(A) A novel process for preparing 7-aminodesacetoxy cephalsporanic acid (7-ADCA) is claimed comprising (a) maintaining in a culture medium capable of sustaining its growth, a strain of Penicillium chrysogenum (PC) which produces isopenic...
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JP2970918B2 |
DNA encoding the gene for the synthetase enzyme capable of generating delta (L- alpha -aminoadipyl)-L- cysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, ...
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JP2954601B2 |
Novel methods and compositions are provided for the enhanced production of secondary metabolites. Methods are provided for identifying sequences which when transformed into secondary metabolite producing hosts, enhance the production of ...
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JP2930546B2 |
To obtain a new protein obtained from a DNA sequence having a configuration of a specific restriction cite cloned to a plasmid derived from Streptomyces, involving biosynthesis of a β-lactam compound and usable for synthesis of an antim...
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JPH11506025A |
Process for increasing production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the pcl gene. The pcl gene codes for the enzyme phenylacetyl-CoA ligase. The pcl gene obtained from Pseudomonas putida U, an...
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JPH11505425A |
Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultraf...
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JP2875625B2 |
NEW MATERIAL:A compound of formula I (R is H, salt, alkyl, alkoxyalkyl; X is group of formula II-IV). USE:An antibiotic. PREPARATION:Penicillin is treated with an oxidase, and the produced accumulated product is separated and purified.
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