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WO/2000/071579A2 |
The present invention relates to a method for modulating the production of secondary metabolites in the fungus Penicillium chrysogenum by influencing the homeostasis of organelles by modulating a least one gene which is directly related ...
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WO/2000/066751A1 |
The present invention provides an expression cassette comprising a DNA sequence of a species encoding a protein which is combined with a DNA sequence encoding a secretion signal peptide of an A. faecalis species. The sequence of the spec...
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WO/1999/067390A1 |
The present invention discloses novel sulphate permease-encoding genes obtained from a $g(b)-lactam producing micro-organism. The present invention also relates to the use of said genes for the improvement of the production of a $g(b)-la...
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WO/1999/032113A1 |
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the r...
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WO/1999/020786A1 |
Process for the preparation of a $g(b)-lactam antibiotic in which a $g(b)-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation agent/$g(b)-lactam nucleus of less ...
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WO/1999/015532A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 °C and ...
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WO/1999/015531A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains...
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WO/1999/013098A1 |
Lactams, for example 6-aminopenicillanic acid (6-APA), may be prepared by enzymatic conversion of a first compound, for example penicillin-G, in a solvent mixture comprising water and a non-aqueous organic solvent, especially 1,1,1,2-tet...
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WO/1999/001566A1 |
An improved method has been provided for the enzymatic bioconversion of $g(b)-lactam compounds by the application of a preparation of an enzyme or enzymes with a low level of $g(b)-lactam degrading activity. Especially the application of...
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WO/1999/001561A1 |
The present invention discloses an enzyme obtainable from $i(P. chrysogenum) which is an O-acetyl-L-serine sulfhydrylase (OAS sulfhydrylase). It is shown for the first time that $i(P. chrysogenum) contains an enzyme activity associated w...
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WO/1998/056946A1 |
The invention relates to a process for the preparation of ampicillin in which 6-aminopenicillanic acid (6-APA) is subjected to an enzymatic acylation reaction with the aid of a phenylglycine derivative, with the total concentration of th...
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WO/1998/056944A1 |
Disclosed is a method to improve the quality of enzymatic hydrolysis or synthesis of the substituted $g(b)-lactam compounds with respect to enzyme productivity, product quality and process streamlining (prevention of the formation deposi...
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WO/1998/056945A1 |
The invention relates to a process for enzymatically preparing a $g(b)-lactam antibiotic from a $g(b)-lactam nucleus or a salt thereof and a precursor for a side chain, wherein a large amount of enzyme is used, which amount is at least t...
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WO/1998/048038A1 |
The invention relates to a method for preparing a $g(b)-lactam antibiotic, wherein an $i(N)-substituted $g(b)-lactam, having general formula (I), wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized...
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WO/1998/048035A1 |
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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WO/1998/048034A1 |
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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WO/1998/048037A1 |
The invention relates to a method for controlling the solubility of a $g(b)-lactam nucleus having general formula (I) wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized form of sulfur; and Z is (a...
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WO/1998/048019A1 |
Process for inactivating genes which code for enzymes of the phenyl acetate catabolism, plasmids containing them and strains transformed therewith. The process applies preferably to the gene $i(pahcA) of $i(A.nidulans) and to the gene $i...
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WO/1998/048039A1 |
The present invention discloses an improved process for the preparation of 6-amino penicillanic acid (6-APA) from a fermentatively produced N-substituted penicillin, comprising the steps of extraction of the N-substituted penicillin comp...
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WO/1998/039459A1 |
The invention relates to promoters of the genes glutamate desydrogenase, $g(b)-acetylhexosaminidase and $g(g)-actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the...
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WO/1998/037179A2 |
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...
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WO/1998/027221A1 |
The present invention discloses a fermentative process for the production of penicillin G or V or cephalosporin G or V derivatives wherein certain derivatives of phenylbutyric acid are used as a side chain precursor. In said phenylbutyri...
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WO/1998/004732A1 |
Disclosed is a process for the synthesis of $g(b)-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
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WO/1997/035029A1 |
Alternative process to obtain 6-amino-penicillanic acid. The process comprises the substitution of the steps of extraction with organic solvents and isolation and separation as solid material of the intermediary penicillin salt, by a cul...
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WO/1997/035013A1 |
Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum through the expression of the gene pcl. The gene pcl codes for the enzyme phenylacetyl-CoA ligase. Through recombinant DNA techniques, th...
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WO/1997/022610A1 |
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a 'beta'-lactam core is acylated, the antibiotic i...
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WO/1997/004086A1 |
A new immobilized Penicillin G acylase with a surprisingly good performance has been provided for. By applying this new immobilized enzyme, 'beta'-lactam derivatives are prepared in high yield by enzymatic reaction of a parent amino 'bet...
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WO/1997/002349A1 |
A process for preparing an enzyme from Penicillium chrysogenum having Phenylacetate-Coenzyme A activity. DNA encoding for the enzyme is also provided and its use in the production of modified strains.
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WO/1996/030376A1 |
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is h...
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WO/1996/010085A1 |
The present invention relates to biosynthesis 'beta'-lactam antibiotics. More specifically, the invention relates to processes of producing 'beta'-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of ca...
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WO/1996/010084A1 |
The invention relates to an improved process for the production of a secondary metabolite comprising (i) fermentation of a microorganism capable of producing said secondary metabolite, and (ii) recovering said metabolite in substantially...
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WO/1996/005318A1 |
New mutant 'beta'-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G acylase and having an amino acid sequenc...
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WO/1996/002663A1 |
'beta'-Lactam derivatives can advantageously by synthesized by an enzymatic reaction of the parent amino 'beta'-lactam with the corresponding acylating agent at constantly high concentrations of said reactants.
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WO/1995/034675A1 |
The present invention provides an improved method for enzymatic acylation to prepare semisynthetic 'beta'-lactam antibiotics by the application of modulators to suppress the hydrolysis of the acylating agent more than the synthesis of th...
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WO/1995/003420A1 |
Process for the preparation of a beta-lactam derivative, wherein in an enzymatic reaction a beta-lactam nucleus is coupled to D-phenylglycine amide, and the enzyme, the solid phenylglycine and the beta-lactam derivative are separated out...
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WO/1993/023164A1 |
The present invention relates to a method of separating a particulate solid catalyst from a chemical reaction mixture which further comprises at least one other solid component, either during the reaction or after the reaction.
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WO/1993/012250A1 |
The present invention relates to an improved method for the preparation of certain $g(b)-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate.
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WO/1993/008287A1 |
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum)...
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WO/1993/005158A1 |
An important intermediate for preparing cephalosporin antibiotics, 7-aminodesacetoxy cephalosporanic acid (7-ADCA), is prepared by a novel bioprocess in which a transformed $i(Penicillium chrysogenum) strain is cultured in the presence o...
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WO/1993/004188A1 |
Described is a method for the fermentative production of cephalosporin C, the fermentation solution being filtered during fermentation through a cross-flow filtration system. The filtrate obtained from the fermenter can be used again.
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WO/1992/012782A1 |
The present invention relates to a process for separating, from each other, one non-dissolved catalyst from one or more other non-dissolved components present in a reaction mixture. The separation is obtained by using a catalyst having a...
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WO/1992/007079A1 |
A transformant selection system has been developed, particularly for a beta-lactam producing strain, more particularly for P. chrysogenum, by the complementation of a mutation of said beta-lactam producing strain by a homologous selectio...
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WO/1992/001061A1 |
beta-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta-lactam derivative in the rea...
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WO/1991/019788A1 |
A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of beta-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido ...
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WO/1991/009136A1 |
Synthesis of semi-synthetic monobactamic or beta-lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monop...
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WO/1989/005350A1 |
DNA encoding the gene for the synthetase enzyme capable of generating delta(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g....
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WO/1988/000203A1 |
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N-C8-C14 alkyl pyrrolidone extractant and the process involving the extraction of said antibiotic.
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WO/1982/001563A1 |
Method for carrying out biological and chemical conversion processes which require the presence of one or more catalytically active substances, such as enzymes, microorganisms, cells, organelles, cell homogenates, and organic or inorgani...
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JP5821132B2 |
The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by transformation with nucleotide sequences coding for a xylose isomerase that has ...
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JP5794606B2 |
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