Title:
【発明の名称】6-アミノペニシラン酸(6-APA)を製造するためのかわりの方法
Document Type and Number:
Japanese Patent JPH11505425
Kind Code:
A
Abstract:
Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the culture broth in at least 2 successive stages. The first stage has a cut-off for molecular weights of 20,000 Dalton and the second, 2000 Dalton. Subsequent to the enzyme conversion stage the products from that stage are subjected to a series of anionic exchange chromatography steps.
Inventors:
Olivier Lewis, Manuel
Fly Ray Jekola, Nives
Gonzales de Prado, Emiliano
Bitterre Alba, Alejandro
Salto Maldonado, Francisco
Fly Ray Jekola, Nives
Gonzales de Prado, Emiliano
Bitterre Alba, Alejandro
Salto Maldonado, Francisco
Application Number:
JP53316797A
Publication Date:
May 21, 1999
Filing Date:
March 14, 1997
Export Citation:
Assignee:
Antibiotics, Socieda Anonima
International Classes:
B01D61/14; C07D499/10; C07D499/12; C07D499/18; C07D499/42; C12P37/06; (IPC1-7): C12P37/06; C07D499/10; C07D499/12; C07D499/18; C07D499/42
Attorney, Agent or Firm:
Takashi Ishida (3 others)