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WO/2004/003210A2 |
Methods for preparative in vitro biocatalysis utilizing oxidoreductases. These methods are based on novel approaches to supply the oxidoreductases with reduction equivalents derived either from chemical or electrochemical sources. By uti...
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WO/2004/001031A1 |
Sulfated fucan lyase capable of decomposing sulfated fucan derived from sea cucumber; a process for producing the enzyme; a low molecular compound obtained by causing the enzyme to act on sulfated fucan; a process for producing the same;...
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WO/2003/100036A2 |
The invention concerns novel antiretroviral sulpholipids extracted from spirulinae, a method for obtaining same, compositions containing same and use thereof as HIV-1 and HIV-2 inhibitors. The invention also concerns a spirulina biomass ...
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WO/2003/087386A2 |
The invention relates to methods for producing sulphurous fine chemicals, in particular L-methionine, by fermentation, using bacteria, in which a nucleotide sequence that codes for a methionine synthase metH gene is expressed.
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WO/2003/037829A2 |
This invention relates to the enzymatic synthesis of oligopehnols on solid support by sequential enzymatic addition of reaction solutions containing phenols. The oligomers are then selectively build up on the solid surface. When used in ...
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WO/2003/029477A1 |
The compounds of formula (I) are useful for the preparation of 1,5-benzothiazepines which are useful as enzyme inhibitors, such as protease, interleukin-1$g(b)-converting enzyme, elastase or angiotensin enzyme, GPCR antagonists (cholecys...
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WO/2003/029495A2 |
The invention relates to compounds of formula (I), which are formed from the micro-organism Coniochaeta ellipsoidea Udagawa, DSM 13856, or from one of its mutations and/or variants during fermentation and which optionally are chemically ...
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WO/2002/103025A1 |
A sulfated saccharide represented by the following general formula: [A]−(6SO3−GlcNAc)−[C]−R wherein (6SO3−GlcNAc) represents a 6−sulfated N−acetylglucosamine residue&semi [A] represents hydroxy or a saccharide residue&semi ...
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WO/2002/095044A2 |
A method for catalyzing reactions of aryl-thiols and aryl-thioesters with water, alcohol or carboxylic acid using an enyzme or microorganism leading to the hydrolysis, esterification or trans-esterification or these compounds, which is p...
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WO/2002/085293A2 |
Engineered microorganisms that produce at least 200 $g(m)g alpha-lipoic acid (ALA) per g dry cell weight and engineered microorganisms that secrete at least a 2-fold greater amount of ALA than an amount of ALA found intracellularly, are ...
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WO/2002/077250A2 |
The present invention describes a process for the production of enantiomer-enriched $g(a)-substituted carboxylic acids with the assistance of the hydantoinase/carbamoylase enzyme system. The compounds to be used comprise substances of th...
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WO/2002/059342A1 |
A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1
-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one is...
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WO/2002/036794A1 |
The invention relates to a method for the enzymatic oxidation of substrates. When converting organic substrates using H¿2?O¿2? by means of enzymes, the enzymes are deactivated during the course of the conversion by the aggressive H¿2?...
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WO/2002/022849A2 |
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C¿6? or C¿10? aromatic group that can be substituted with H, C¿1? to C¿6? alkyl, trifluoromethyl or hal...
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WO/2002/016627A2 |
A class of biopolymer including sulfur in the form of a thioester in the polymer backbone or a thioether in the polymer side chains has been developed. These are preferably produced by fermentation of bacteria with appropriate sulfur con...
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WO/2002/012534A2 |
The present invention relates to compounds made by a subset of modules from one or more polyketide synthase ('PKS') genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring p...
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WO/2002/000869A2 |
An enzymatic catalyst in the granular form which is non-dispersible in water comprising an inner core provided with a coating which coating comprises an enzymatic material characterised in that the coating has a thickness of from 30 to 4...
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WO/2001/098518A2 |
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicam...
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WO/2001/077096A2 |
This invention relates to a process for the preparation of thioacetates addition of thioacetic acid or a salt thereof on $g(a)-,$g(b)-, or $g(g)-unsaturated alcohols, carbonyl compounds or cyclic or acyclic alkenes or by nucleophilic sub...
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WO/2001/077359A2 |
This invention relates to the generation of natural flavouring thiols and their disulfides derivates by bioconversion and their use as enhancers or intensifiers of flavour in food product. The invention also relates to new aroma compound...
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WO/2001/053309A1 |
The present invention provides isolated nucleic acid molecules that encode one or more of the enzymes required to produce PDTC. The present invention also provides isolated proteins encoded by nucleic acid molecules of the invention. In ...
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WO/2001/040498A1 |
Optically active compounds of general formula (III) or salts thereof [wherein * represents an asymmetric center; A is an optionally substituted benzene ring; Alk is optionally substituted methylene; and R is R?1¿ or OR?1¿ (wherein R?1Â...
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WO/2001/031049A2 |
Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do ...
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WO/2001/031035A2 |
Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do ...
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WO/2001/027306A2 |
The use of enzymes which catalyze the production of starter and extender units for polyketides is described. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally desi...
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WO/2001/018548A2 |
Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aque...
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WO/2001/002596A1 |
The novel method enables oxidation of organic compounds with peroxycarboxylic acids which are produced in situ in the presence of enzymes by reacting hydrogen peroxide with saturated aliphatic carboxylic acid esters and/or mixtures of co...
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WO1999043791A9 |
The invention relates to diisopropyl fluorophosphatase (enzyme classification EC 3.1.8.2.) from Loligo vulgaris and to the base sequence which codes the enzyme. The invention also relates to the additional vectors which contain the inven...
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WO/1999/051747A1 |
A novel gene encoding enzymes capable of degrading hardly degradable thiophene compounds. Use of this gene makes it possible to liberate sulfur atoms from thiophene compounds contained in fossil fuels such as petroleum, thus preventing t...
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WO/1999/045134A1 |
The present invention relates to a process for preparing an (R)-$g(a)-alkyl-$g(b)-thiolactone or an (S)-$g(a)-alkyl-$g(b)-mercaptopropionic acid by stereo-selectively hydrolyzing a mixture of R and S enantiomers of $g(a)-alkyl-$g(b)-thio...
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WO/1999/042590A1 |
The invention relates to a biotechnological method for producing trifluoro-3(R)-hydroxybutyric acid derivatives of the general formula (I), where R?1¿ represents -OR?2¿, where R?2¿ is hydrogen, C¿1-10? alkyl, C¿1-10? alkenyl, C¿3-8...
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WO/1998/048029A1 |
Optically active cyclopentanecarboxylic acid derivatives (such as cystacyclin or sarkomycin) exhibiting the activity of inducing the differentiation of nerve cells can be produced through fermentation in a high yield by cultivating a cys...
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WO/1998/032872A1 |
Enzymes derived from the isolated and substantially purified microorganisms of the present invention, designated herein as stains 52 and 56wt, are capable of hydrating nitriles such as 2-hydroxy-4-(methylthio)-butanenitrile (HMB-nitrile)...
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WO/1998/018941A1 |
The invention concerns a method for preparing 2-hydroxy 4-methylthio butyric acid and/or the ammonium salt of 2-hydroxy 4-methylthio butyric acid by enzymatic hydrolysis of 2-hydroxy 4-methythio butyronitrile characterised in that: a) in...
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WO/1997/039115A1 |
Immobilized garlic alliinase wherein the alliinase is chemically, physically or biologically immobilized, is useful in a method for continuous production of allicin. The method comprises adding a solution of alliin as substrate to a colu...
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WO/1996/031614A1 |
A process is described for the dimerization of a substituted aromatic compound of formula (I) wherein X represents -OH, -SH or -NHR where R is H, an alkyl group or an aryl group; R1 and R2 represent an alkyl group, an aryl group, an alke...
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WO/1996/029424A1 |
A process for the enzymatic synthesis of sulfate esters is disclosed in which intermediate phosphorylated adenosine compounds are recycled to minimize enzyme inhibition. Exemplary enzymes include ATP sulfurylase, APS kinase and a sulfotr...
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WO/1996/017075A1 |
A process for producing sulphoxide enriched in the (R) or the (S) enantiomer as required comprises contacting a racemic mixture of such sulphoxide with the enzyme DMSO reductase derived from a bacterium selected according to the enantiom...
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WO/1996/009403A1 |
A novel method for the enzymatic hydrolysis of 4-methylthiobutyronitriles into racemic 4-methylthiobutyric acid using a nitrilase of Alcaligenes faecalis, Rhodococcus sp. HT 29-7 or Gordona terrae.
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WO/1996/008577A1 |
There is disclosed a novel microbial bioconversion process for the synthesis of a trans-hydroxy sulfone intermediate, which is the precursor to topical carbonic anhydrase inhibitors (TCAI's). TCAI's are effective in the treatment of glau...
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WO/1996/003518A1 |
The invention concerns a process for preparing mercapto compounds comprising the step of demethylating an S-methyl-mercapto compound of Formula (I) to the corresponding mercapto compound of Formula (II), using a microorganism which is ca...
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WO/1995/023232A1 |
A method of producing a gel, comprising adding a phenol oxidizing enzyme system to a solution of lignosulphonates (optionally substituted), and holding for a sufficient time to form a gel.
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WO/1994/026918A1 |
The invention concerns a process for preparing S-methylmercapto and mercapto compounds comprising the step of demethylating a dimethylsulfonium compound of formula (I) to the corresponding S-methylmercapto compound of formula (II), using...
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WO/1994/008614A1 |
A recombinant protein in a substantially pure form having the activity of garlic alliinase, a DNA sequence encoding the protein, an expression vector containing the DNA sequence, host cells transfected with the expression vector, a proce...
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WO/1993/008293A1 |
A method for producing carboxylic acids, wherein the corresponding alcohols or aldehydes are completely oxidized using micro-organisms of the genus Saccharomyces, Hansenula, Pichia, Candida or Kluveromyces. The method is used, inter alia...
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WO/1993/004055A2 |
This invention relates to new compounds, known compounds and new uses for those compounds. The compounds of this invention are comprised of tetronic acid type compounds, panosialin type compounds and virustomycin type compounds that are ...
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WO/1993/002034A1 |
Enantiomer-free compounds having the formula (I) are disclosed, in which the substituents R?1¿, R?2¿ and R?3¿ have the meaning described in the claims, as well as a process for preparing the same and their use for producing enantiomer...
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WO/1991/014783A1 |
The invention relates to a process for converting peroxycarboxylic acids to carboxylic acids, the process comprising treating a peroxycarboxylic acid of the general formula: R-CO-OOH, wherein R is a linear or branched alkyl group, an ary...
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WO/1989/011535A1 |
A method of methylating organic compounds which is potentially cheaper than conventional esterification of carboxylic acids or methylation of phenols which comprises contacting the substance that is to be methylated within methyl donor m...
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WO/1988/005042A1 |
Therapeutical compositions containing products obtained from the addition of thiols to prostaglandines or analogues of prostaglandines. These compositions have an antitumoral activity.
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