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WO/2023/060225A1 |
A sampling device is disclosed, including a substrate, a reservoir surface disposed on at least a portion of the substrate and configured to retain a liquid, the reservoir surface having a reservoir surface area and being formed of a res...
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WO/2023/057881A1 |
Systems and methods are provided for processing in real-time and using Gaussian fitting digitized signals from ions detection in time-of-flight (TOP) mass spectrometry. Acquisition/analog-to- digital conversion may be applied in the cour...
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WO/2023/058248A1 |
This mass analysis device comprises: a vacuum container; a detector; a buffer material; a pressing member; and a compression-amount restricting mechanism. The vacuum container is used for mass analysis of a sample. The detector, buffer m...
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WO/2023/057744A1 |
An ion detector for a mass and/or ion mobility spectrometer is disclosed. The ion detector comprises a dynode arranged and configured such that primary ions to be detected by the ion detector impact upon the dynode and generate first ele...
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WO/2023/057927A1 |
A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The target...
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WO/2023/059645A1 |
A drop-in multi-optics module for a quantum-particle (e.g., rubidium, cesium) cell provides for more convenient and cost-effective manufacture of such cells (including vacuum cells, cold/ultra-cold matter cells, vapor cells, and channel ...
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WO/2023/053624A1 |
A support unit according to the present invention comprises a first support body and a second support body. The first support body has an ionization substrate. The second support body is arranged to face the first support body. The secon...
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WO/2023/053296A1 |
This mass spectrometer comprises: a quadrupole mass filter including first, second, third, and fourth rod electrodes; a first voltage application unit that applies first high-frequency alternating-current voltage to the first and second ...
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WO/2023/052966A1 |
In one aspect, a method for fragmenting ions in a mass spectrometer is disclosed, which includes introducing a plurality of precursor ions into a collision cell of a mass spectrometer, generating a potential barrier in the collision cell...
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WO/2023/053041A1 |
In one aspect, a mass spectrometer is disclosed, which includes an ion path along which an ion beam can propagate, and an ion beam deflector positioned in the ion path and configured to modulate transfer of an ion beam received from an u...
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WO/2023/053583A1 |
A sample support according to one embodiment of the present invention is provided with: a support substrate having a support face; a sheet-shaped adhesion layer provided on the support face; an ionization substrate that is provided on th...
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WO/2023/047267A1 |
A method for performing mass spectrometry (MS) comprises receiving MS data corresponding to a plurality of MS runs, wherein MS data corresponding to an MS run of the plurality of MS runs comprises detected intensities for a plurality of ...
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WO/2023/048958A1 |
A method of milling a sample that includes a first layer formed over a second layer, where the first and second layers are different materials, the method comprising: milling the region of the sample by scanning a focused ion beam over t...
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WO/2023/047302A1 |
In one aspect, a method of operating a mass spectrometer is disclosed, which comprises ionizing a sample to generate a plurality of ions, and introducing at least a portion of the ions into an inlet orifice of the mass spectrometer. At l...
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WO/2023/049276A1 |
Aspects of the subject application include applying a spatial barcode to a cellular sample and then performing suspension mass cytometry on the cellular sample. For example, a sample barcode comprising a known distribution of sample barc...
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WO/2023/046837A1 |
An analytical system (100, 100') comprising a mass spectrometer (60) and an ionization source (61) coupled to the mass spectrometer (60) is herein disclosed. The analytical system (100, 100') further comprises an analytical fluidic syste...
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WO/2023/048903A1 |
Aspects of the present disclosure include circuits, systems and methods for baseline signal restoration over differential outputs. Circuits according to certain embodiments include an input module for receiving a signal from a sensor, an...
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WO/2023/047366A1 |
A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality ...
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WO/2023/047546A1 |
This mass spectrometer is provided with: an ionization part which has a nozzle for spraying a sample liquid and an ionization electrode and which ionizes a compound in the sample liquid by an atmospheric pressure ionization method; a hea...
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WO/2023/048611A1 |
A charged particle spectrometer (100) is described, which comprises an imaging energy analyser (101) and an electrostatic lens system (102), having a first deflector (16A/16C, 16B/16D) and optionally a second deflector (17A/17C, 17B/17D)...
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WO/2023/046716A1 |
The present invention relates to a composition comprising (i) cesium iodide, (ii) ethylamine and/or formic acid, and (iii) methanol and/or water. The present invention further relates to a method for calibrating a mass spectrometry (MS) ...
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WO/2023/047304A1 |
Methods and system that determines disulfide and trisulfide linkages within analytes (e.g., polypeptides) is described. In certain aspects, a sample comprising polypeptides (such as an antibody) may be subjected to dissociation using an ...
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WO/2023/044582A1 |
Rapid calibration of a quantitative analysis instrument such as a mass spectrometer is performed using a calibration chip surface having different sized surface energy traps (SETs) and a transfer chip surface having same sized SETs, wher...
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WO/2023/042369A1 |
Provided is a mass spectroscopy device 1 comprising: a probe 111 which sprays a liquid sample; an electrical discharge electrode 112 which is disposed at a position where the liquid sample is sprayed from the probe 111; an electrical dis...
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WO/2023/044036A1 |
The present invention generally pertains to methods of characterizing at least one protein of interest in a biological sample. In particular, the present invention pertains to the use of automated iterative tandem mass spectrometry (AIMS...
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WO/2023/042348A1 |
This mass spectrometry device comprises an ionizing unit which has an ionizing electrode and which ionizes a compound in a sample solution by means of atmospheric pressure ionization, a high-voltage power source for applying a voltage to...
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WO/2023/041937A1 |
An ion source assembly comprising: a target plate for holding a sample to be analysed; a laser for ionising the sample on the target plate so as to form analyte ions; one or more optical elements; an ion guide for guiding the analyte ion...
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WO/2023/037313A1 |
Methods and systems for adjusting instrument setting, improving fidelity of isotope pattern for mass spectra, and/or determining molecular mass with improved accuracy are disclosed. In one example, a method for determining Mmono of a com...
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WO/2023/037306A2 |
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WO/2023/035045A1 |
The present invention provides diagnostic and/or prognostic markers indicative of liver fat, fatty liver diseases (e.g. non-alcoholic fatty liver disease (NAFLD) and/or hepatocellular cancer deriving from liver fat.
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WO/2023/037307A1 |
A method of ejecting a sample from a nebulizer nozzle fluidically coupled to a port via a transfer conduit includes receiving at the port a transport liquid and the sample. The transport liquid and the sample in the transfer conduit is t...
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WO/2023/037267A1 |
Disclosed are methods and systems that provide for the analysis of one or more analytes of interest in an acoustic ejection mass spectrometer (AEMS) system that incorporates an open port interface (OPI) and differentiation mass spectrome...
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WO/2023/036881A1 |
The invention relates to a method for detecting one or more leaks in a battery enclosure (101) of a battery (100), the battery (100) including at least one electrochemical cell (102) enclosed in the battery enclosure (101), or detecting ...
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WO/2023/037293A2 |
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WO/2023/037295A2 |
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WO/2023/031880A1 |
Methods and systems for automatically analyzing a collection of samples, the method including ionizing a plurality of samples, capturing a plurality of raw mass spectra for the ionized plurality of samples, correlating captured respectiv...
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WO/2023/031871A1 |
Methods and systems for assessing a quality of mass analysis data generated by a mass analysis device, including collecting mass spectrometry data for a given compound, deriving a measured isotope profile based on the collected mass spec...
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WO/2023/032983A1 |
This mass spectrometer comprises: a processing chamber in which an analysis process is executed, in a vacuum state, on a sample contained in a sample plate; a housing chamber having an opening/closing door through which the sample plate ...
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WO/2023/030581A1 |
The invention relates to a sample carrier (100) for holding a sample in an evacuated environment or a defined gas atmosphere. The sample carrier comprises a cover plate (10) and an electrical operating device (20) which is connected to t...
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WO/2023/031870A1 |
A method for improved mass spectrometry by determining charge state of precursor ions from an analysis of product ions, includes receiving sample ions. A group of precursor ions is selected from the received sample ions based on mobility...
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WO/2023/031833A1 |
Methods and systems for mass analysis are disclosed herein. An example system includes: a sample ejector configured to eject a plurality of samples from a plurality of wells of a well plate; a capture probe configured to capture the ejec...
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WO/2023/028696A1 |
A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leav...
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WO/2023/031605A1 |
A nebuliser outlet assembly comprises an inlet end and an outlet end, and a first channel (24) arranged between the inlet end and the outlet end, wherein the first channel is configured to receive a capillary. The nebuliser outlet assemb...
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WO/2023/026145A1 |
Systems and methods are described that facilitate effective detection and quantification of hydrogen fluoride within a sample utilizing mass spectrometry (MS). A MS analysis is performed on a gas sample to obtain an unfiltered set of MS ...
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WO/2023/026190A1 |
In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being config...
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WO/2023/026201A2 |
A system for applying RF voltages to a multipole ion processing device, configured for use in a mass spectrometer, includes a first RF generator configured to generate a first RF voltage and apply to a first pole electrode set, a second ...
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WO/2023/026192A1 |
An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for a...
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WO/2023/025400A1 |
A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (f) within an ion analyser apparatus. A dat...
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WO/2023/026136A1 |
Systems and methods are disclosed for performing a DDA mass spectrometry experiment. A precursor ion survey scan of a mass range is performed to generate a precursor ion peak list. A series of steps are performed for each precursor ion p...
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WO/2023/028227A1 |
Spectrofilometers are provided. The spectrofilometer includes a profilometer, an enclosure, one or more interferometer beam-splitting elements, and/or one or more spectrometer beam-dispersing elements. The one or more interferometer beam...
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