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WO/2016/207266A1 |
The present invention relates to a process to prepare N,N'-di(2-hydroxybenzyl) ethylenediamine-N,N'-diacetic acid and salts thereof (HBED) comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof (EDDA)...
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WO/2016/207265A1 |
The present invention relates to a process to prepare N,N'-di(2-hydroxybenzyl) ethylenediamine-N,N'-diacetic acid and salts thereof comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof and phenol at...
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WO/2016/202252A1 |
The present invention relates to the field of compound synthesis and discloses a method for synthesizing D-para-hydroxyphenylglycine methyl ester. The method comprises the steps of: (1) in the presence of thionyl chloride, carrying out a...
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WO/2016/197580A1 |
The present invention discloses a method of synthesizing an α-amino acid derivative with α-alkyl side chain substitution. The method comprises: reacting an alkene with 9-bbn at 0-80˚C for 0.5-12 h, and then adding an imine to react at...
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WO/2016/193740A1 |
The invention relates to a process for the preparation of one or more intermediate chemical compounds useful in the preparation of non-ionic contrast agents wherein the process is carried out continuously using one or more flow procedures.
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WO/2016/194586A1 |
A radioactively labeled compound production device (100) is a production device for producing a radioactively labeled compound by introducing a radioactive isotope into a non-radioactively labeled precursor compound. The production devic...
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WO/2016/179692A1 |
The present disclosure provides a process for preparing iminodisuccinic acid salts using maleic anhydride, aspartic acid, and a base in water. In an example, maleic anhydride and aspartic acid are mixed with a base to form a slurry, pref...
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WO/2016/180664A1 |
Process for making a chelating agent according to the general formula (I), R1-CH(COOX1)-N(CH2COOX1)2 wherein R1 is selected from hydrogen, C1-C4-alkyl, phenyl, benzyl, CH2OH, and CH2CH2COOX1, X1 is (ΜχΗ1-χ), M being selected from alk...
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WO/2016/173960A1 |
The invention relates to an optimized synthesis of pregabalin and additional 4-aminobutane acids using an improved method for producing conjugated nitroalkenes. This is achieved by a nitro-aldol reaction of an aliphatic aldehyde with a n...
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WO/2016/171240A1 |
The present invention addresses the problem of providing an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme. (In the formulae, R1 represents a C1-C6...
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WO/2016/164748A1 |
This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further downstream purification.
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WO/2016/164767A1 |
The present disclosure relates to methods for separating at least one amine chosen from diamines and omega-aminoacids from a feed mixture using a simulated moving bed (SMB) adsorptive technology.
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WO/2016/155596A1 |
Disclosed is a method of synthesizing a 3-halo-D-alanine methyl ester or an acid salt thereof. By reacting a D-serine methyl ester or an acid salt thereof and a halogenation reagent in an organic solvent, the method prepares a 3-halo-D-a...
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WO/2016/153064A1 |
[Problem] To provide a novel diamine for imparting a thin film that has not only exceptional flexibility and transparency, but also low retardation. [Solution] Provided are: a diamine characterized by being represented by formula (1-1); ...
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WO/2016/151990A1 |
The present invention relates to novel tertiary alcohol derivatives substituted with aryl and trifluoromethyl, and optical isomers thereof. In addition, the present invention also relates to methods for the preparation and use as enantio...
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WO/2016/150953A1 |
The present invention relates to a process for synthesis of 4,5,6,7- tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to ob...
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WO/2016/147133A1 |
The present invention provides a novel process for the preparation of droxidopa, a synthetic amino acid precursor of norepinephrine. The process is a stereoselective process for the preparation of droxidopa using asymmetric induction and...
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WO/2016/147132A1 |
The present invention provides a novel process for the preparation of droxidopa, a synthetic amino acid precursor of norepinephrine. The process is a stereoselective process for the preparation of droxidopa using asymmetric induction and...
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WO/2016/142220A1 |
The present invention is directed towards mixtures comprising (A) 90 to 99.9 % by weight of a mixture of L- and D-enantiomers of methyl glycine diacetic acid (MGDA) or its respective mono-, di- or trialkali metal or mono-, di- or triammo...
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WO/2016/140104A1 |
The present invention provides a 3-phenylisoserine derivative production method for obtaining 3-phenylisoserine derivatives represented by formula (2) (in the formula, R1 represents a phenyl group or a phenyl group having a substituent g...
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WO/2016/135397A1 |
The process for producing amino acids from volatile fatty acid (VFA) molecules, termed precursors, produced by anaerobic fermentation from fermentable biomass, comprises at least the following steps: - a) extracting the volatile fatty ac...
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WO/2016/133217A1 |
The present invention is able to provide a method for stereoselectively introducing an amino group having various substituents into the α-position of an oxindole compound by a single step by having a specific compound (a carbonyl compou...
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WO/2016/128924A1 |
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new c...
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WO/2016/103192A1 |
The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the peptides and conjugate...
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WO/2016/099465A1 |
Disclosed are salts, such as nitrates, of propionyl-L-carnitine and methods of making the compounds.
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WO/2016/097026A1 |
Use of methyl glycine diacetic acid (MGDA) as additive in processes for recovering crude oil and/or gas from subterranean formations, wherein the MGDA is a mixture of L- and D-enantiomers of MGDA or salts thereof, said mixture containing...
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WO/2016/083455A1 |
A process for the precipitation of one or more amino and/or organic acids from a liquid feed comprising a plurality of amino and/or organic acids, comprising providing, in a precipitation vessel, a solution of amino and/or organic acids ...
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WO/2016/071249A1 |
The present invention relates to a novel method for producing substituted biphenylamines.
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WO/2016/071341A1 |
A process comprising (a) contacting a sulfur compound and a polar organic compound to produce a sulfur complex mixture, wherein the sulfur complex mixture comprises a sulfur complex, (b) continuously introducing at least a portion of the...
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WO/2016/072941A1 |
This invention relates to a method for preparing diethanolamine derivatives having the structure (I): Formula (I); wherein Formula (II); R1 represents structure (II) R2 represents hydrogen or structure (II); X represents hydrogen, alkali...
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WO/2016/058875A1 |
Aqueous solution containing in the range of from 60.5 to 75 % by weight of a mixture of trialkalimetal salts of the L-and D-enantiomers of methyl glycine diacetic acid (MGDA), said mixture containing predominantly the respective L-isomer...
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WO/2014/133291A9 |
The present invention relates to: a method for easily preparing (2RS)-amino-(3S)-hydroxy-butyric acid, which is a chiral amino acid, in a high yield and a high purity using a chemical synthesis and an enzymatic reduction reaction; an int...
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WO/2016/055015A1 |
Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: under the existence of transition metal catalyst of chiral phosphine ligand and hydrogen, conducting asymmetrical reduction ammonification reaction...
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WO/2016/046055A1 |
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...
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WO/2016/042045A1 |
The present invention relates to a method for synthesising an amino ester or mixture of amino esters of formula (I) R1-O-C(O)-(CH2)n-NH2 (I) where n is an integer between 10 and 15, comprising at least the steps consisting of: (iii) subj...
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WO/2016/035080A1 |
The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic es...
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WO/2016/031463A1 |
Provided is the possibility of a novel application of an optical vortex. For this purpose, a method for producing amino acid crystals according to one aspect of the present invention is characterized by comprising irradiating a saturated...
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WO/2016/026196A1 |
Disclosed are a novel double long chain ester-based quaternary-N and synthesis technique thereof, the synthesis steps thereof being as follows: an esterification reaction of halogenated carboxylic acid: mixing a halogenated carboxylic ac...
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WO/2016/020510A1 |
The present invention relates to a method for obtaining crystalline L-alanine from an aqueous solution of L-alanine, in particular from an aqueous solution of L-alanine, which is obtained from a fermentation process.
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WO/2016/017754A1 |
This filter medium for separating a liquid containing water and oil and having a channel for the liquid also has a substrate constituting the channel, and one or more types of nitrogen-containing fluorine-based compounds present on the s...
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WO/2016/017768A1 |
This hydrophilic oil-repellent complex includes one or more types of nitrogen-containing fluorine compounds, and an inorganic compound that has an electric charge or ionic group. The nitrogen-containing fluorine compound includes, within...
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WO/2016/016582A1 |
The present invention relates to a compound of general formula (I), wherein: - n is an integer equal to 1, 2 or 3; - m is an integer equal to 1, 2 or 3; and - M is selected from the alkali metals with the exception of sodium, the alkalin...
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WO/2016/017686A1 |
This hydrophilic oil repellent agent includes at least one species of nitrogen-containing fluorine compound. The nitrogen-containing fluorine compound includes, in the molecule thereof, any one hydrophilicity-imparting group selected fro...
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WO/2016/012386A1 |
The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the wa...
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WO/2016/008393A1 |
The present invention relates to a ceftaroline fosamil amino acid salt and crystal thereof. The ceftaroline fosamil is represented by formula I, and the amino acid is aspartic acid or glutamic acid. The ceftaroline fosamil amino acid sal...
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WO/2015/197379A1 |
Formulations, containing (A) at least one compound selected from methyl glycine diacetate (MGDA) and glutamic acid diacetate (GLDA) and the salts thereof, (B) at least one graft polymer, constructed of (a) at least one graft base, select...
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WO/2015/189068A1 |
The present invention relates to the preparation of β-substituted γ-amino carboxylic acids, preferably in enantiomerically enriched or even enantiomerically pure form, by a one-pot conversion of a β-substituted γ-nitro dicarboxylic a...
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WO/2015/189862A1 |
Described herein is the general synthesis of chiral amine from vinyl nitro compounds using Josiphos catalyst. The process is applied to develop a novel route to Sitagliptin (a DPP-IV inhibitor).
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WO/2015/180486A1 |
The present invention belongs to the technical field of medicine. The present invention relates to a synthesis process of 2-[(2,6-dichlorophenyl)amino]phenylacetic acid 1-(acetoxyl)ethyl ester and the preparation of a fat emulsion inject...
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WO/2015/181304A1 |
The invention relates to a method for preparing a salt of acetylsalicylic acid and a basic amino acid, comprising mixing a solution of acetylsalicylic acid and a solution of said basic amino acid in a reactor, at a temperature lower than...
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