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WO/2009/050365A2 |
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and the salts thereof. The invention is characterised in that it includes a step comprising the peptide coupling of 4 ...
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WO/2009/047446A2 |
The invention relates to a method for converting ricinoleic acid, that comprises the following successive steps: a) fermentation of the ricinoleic acid with a bacterium, a yeast or a fungus in order to obtain 7-hydroxy-9-octadecenedioic-...
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WO/2009/046309A2 |
The present invention provides 3- (aminomethyl)-5-methylhex-4-enoic acid (Pregabalin- 4-eliminate or PRG-4E) and 3- (aminomethyl)-5-methylhex-5-enoic acid (Pregabalin-5-eliminate or PRG-5E), and their uses as reference markers and standa...
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WO/2009/044409A2 |
Present invention relates to a novel and improved process for the resolution of racemic pregabalin of formula (I) into (S)-(+)-pregabalin [(S)-(+)-3-aminomethyl-5-methylhexanoic acid] of formula (III) via the novel acid addition salt [(S...
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WO/2009/043444A1 |
The present invention relates to a process for preparing hydrochloride-free 2-dihaloacyl-3-aminoacrylic esters by reacting acid fluorides with dialkylaminoacrylic acid derivatives.
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WO/2009/044803A1 |
A process for producing a product of the asymmetric-catalyst Michael reaction. By the process, an α,ß-unsaturated aldehyde can be reacted with a nitroalkane such as nitromethane to obtain the corresponding Michael addition product in a...
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WO/2009/045886A1 |
Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.
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WO/2009/041385A1 |
Disclosed is a process for producing an α-type glutamic acid crystal within a short period in a simple and stable manner. The process comprises the following steps (A) and (B): (A) producing a supersaturated glutamic acid solution; and ...
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WO/2009/036898A1 |
The present invention relates to a method for producing 4-aminobut-2-enolides and corresponding intermediates or starting compounds used in the method according to the invention.
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WO/2009/037235A1 |
The invention relates to a process for the preparation of N,N'-bis(2-hydroxybenzyl)-ethylenediamine-N,N'-diacetic acid and its derivatives of general formula (I), wherein both R have the same meaning and are selected from H, C1-C4alkyl, ...
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WO/2009/037137A2 |
The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula I and pharmaceutically acceptable addition salts thereof wherein R1, R1' are independent of each other H or alkyl, R2 is ...
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WO/2009/028707A1 |
It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the...
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WO/2009/024518A1 |
The present invention relates to an alkalimetal salt of glutamic acid-N,N-diacetic acid (GLDA) of the formula NaxKyHzGLDA, wherein x is equal to or more than 2 and lower than 4 and y is more than 0 and equal to or lower than 2, x+y is 3....
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WO/2009/022839A2 |
The present invention relates to a method for preparing pregabalin{ (S) -3- (aminomethyl) -5-methylhexanoic acid}, which is useful for the prevention and treatment of seizure disorders, pains, and psychiatric disorders. According to the ...
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WO/2009/016025A1 |
In a process for the preparation of Na-β-alaninate from β-amino-propionitrile ready for the condensation with pantolactone to pantothenate the improvement of obtaining Na-β-alaninate as a solution in an alcohol, which improvement comp...
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WO/2009/015560A1 |
The invention discloses the use of allylcysteine or its analogs in preparation of medicaments for preventing or treating myocardial damage and the preparation method thereof. The invention further discloses the pharmaceutical composition...
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WO/2009/017056A1 |
Disclosed is a compound containing a structure represented by the general formula (1) below (including the structure of a residue obtained by removing at least one hydrogen atom from the structure represented by the general formula (1) b...
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WO/2009/016879A1 |
It is intended to provide a process for producing an optically active N-(halopropyl)amino acid derivative. This method comprises: the step wherein an optically active alanine ester represented by the formula (I) or its salt (hereinafter ...
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WO/2009/015685A1 |
Method for preparing polymorph form II of gabapentin. This invention refers to an improved method for preparing polymorph Form II of gabapentin, and to the utility thereof as a starting product for the preparation of the marketed pharmac...
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WO/2009/014177A1 |
A reaction mixture containing dibenzofulvene and/or a dibenzofulvene amine adduct, which is produced by the deprotection of an amino acid compound protected with a Fmoc group by reacting the protected amino acid compound with an amine, i...
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WO/2009/010554A1 |
The invention provides a new enantioselective process for the preparation of (S) -pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) ...
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WO/2009/005069A1 |
[PROBLEMS] To provide a method of efficiently deuterating a substrate with the use of a ruthenium catalyst. [MEANS FOR SOLVING PROBLEMS] The method of deuteration is characterized in that a compound having hydroxyl, an optionally substit...
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WO/2009/004643A2 |
The present invention relates to an improved process for the preparation of (S)- Pregabalin of formula (I) and its intermediates thereof. Particularly, the present invention relates to the process for the preparation (S)-Pregabalin havin...
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WO/2009/003979A1 |
What is proposed is a process for producing a free-flowing and storage-stable solid comprising essentially a-alanine-N,N-diacetic acid and/or one or more derivatives of a-alanine-N,N-diacetic acid, proceeding from a powder of a-alanine-N...
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WO/2008/155619A2 |
Methods and materials for preparing an optically active compound of Formula (1), or a pharmaceutically acceptable salt thereof, or an opposite enantiomer of the compound of Formula (1) or pharmaceutically acceptable salt thereof, are dis...
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WO/2008/139539A1 |
A production process capable of efficiently obtaining valacyclovir of high purity chemically and optically is provided. The process for producing valacyclovir represented by the formula (4) or a salt thereof comprising the steps of: neut...
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WO/2008/139080A1 |
The invention relates to a conjugated method for the production of ω-amino-alkanoic acids and dialkylcarbonates having formula R1O-CO-OR1,in which R1 has between 1 and 4 carbon atoms, from an unsaturated fatty acid ester, comprising the...
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WO/2008/138961A1 |
The present invention relates to a method for producing vinyl esters of carboxylic acids by reacting a carboxylic acid with an alkyne composition in the presence of a catalyst, which is selected from salts of perrhenic acid, at a tempera...
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WO/2008/140023A1 |
It is intended to provide crystallization in which between two crystal polymorphisms of glutamic acid, α-crystals which are metastable crystals are preferentially precipitated without precipitating β-crystals which are stable crystals....
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WO/2008/139079A2 |
The invention relates to a conjugated method for the production of ω-amino-alkanoic acids and polyol carbonates from a natural monounsaturated fatty acid, comprising the following zones: I) zone for methanolysis of a natural oil contain...
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WO/2008/138874A1 |
The present invention relates to a novel process for preparing (S)-Pregabalin by optical resolution of racemic Pregabalin. This invention also relates to (S)-Pregabalin-(-)-O,O'-dibenzoyl-L-tartrate or a hydrate, a solvate, a polymorph t...
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WO/2008/139484A2 |
This invention relates to a stable salt of Lofepramine and A process for the synthesis of stable Lofepramine maleate comprising; dissolving maleic acid in ethyl acetate by warming and the solution is then filtered hot; adding purified Lo...
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WO/2008/134936A1 |
Disclosed is a method for extracting threonine from threonine fermentation liquor, comprising: filtrating the sterilized threonine fermentation liquor through ceramic film, decoloring the resulting threonine fermentation liquor by adding...
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WO/2008/135360A1 |
The present invention relates to a method for the crystallization of 2-(4-N,N-diethyl amino-2-hydroxy benzoyl)-benzoic acid-n-hexyl ester, a method for the production of free-flowing or pourable particles of crystalline 2-(4-N,N-diethyl ...
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WO/2008/137512A2 |
There is provided a process for the preparation of Pregabalin which involves the reaction of R-3-(carbamoyl methyl)-5-methyl hexanoic acid, (R)-(+)-phenyl ethyl amine salt with base in an aqueous solution, optional separation of (R)-(+)-...
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WO/2008/134937A1 |
Disclosed is a process for producing the crystal of glutamic acid, which includes filtering the fermented liquid of glutamic acid by ceramic membrane to remove the thallus in the fermented liquid of glutamic acid, then making the obtaine...
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WO/2008/129873A1 |
According to the invention, a DNA encoding phenylalanine aminomutase with selectivity for S-form is acquired and (S)-β-phenylalanine is produced from L-phenylalanine or cinnamic acid and ammonia using a transformant containing the DNA. ...
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WO/2008/117305A2 |
The present invention provides process for the preparation of novel intermediates of (S)-Pregabalin. The present invention also provides process for the preparation of (S)-Pregabalin or a pharmaceutically acceptable salt or solvate there...
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WO/2008/114506A1 |
Disclosed is a method for efficiently producing 4-aminomethylbenzoic acid, which is a production intermediate for tranexamic acid or cetraxate at low cost. Specifically disclosed is a method for producing a compound represented by the fo...
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WO/2008/110529A1 |
The present invention describes a process for the synthesis of an amino acid methyl ester comprising the following steps: (a) refluxing a reaction mixture comprising a free amino acid, methanol and a strong acid; (b) concentrating the mi...
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WO/2008/107661A1 |
There is provided compounds of formula (I), wherein Rx, Ry, X1, X2, L1, L2, Y1 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which...
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WO/2008/106217A1 |
This invention relates to an efficient process for converting gabapentin hydrochloride salt to gabapentin by liquid-liquid extraction using a counter-current extraction method.
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WO/2008/104722A2 |
The invention relates to a method for the synthesis of amino acids / esters of the general formula NH2-(CH2)n-COOR, in which n is an integer between 5 and 14, and R is either H or an alkyl radical including from 1 to 4 carbon atoms, from...
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WO/2008/101608A1 |
A process for the enantioselective preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of racemi...
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WO/2008/102671A1 |
Disclosed is a method for easily isolating/purifying and separating/removing (2S,3R,4S)-4-hydroxyisoleucine with high purity and high yield. Specifically disclosed is a method for purifying (2S,3R,4S)-4-hydroxyisoleucine or a chemically ...
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WO2007072159B1 |
Disclosed are materials and methods for preparing optically active ?-amino acids of Formula (I), which bind to the alpha-2-delta (a2d) subunit of a calcium channel.
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2008/090073A1 |
The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hyd...
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WO/2008/086595A1 |
The present invention provides an improved process for the concurrent generation of hydrogen gas and monosodium glutamate. Said process comprises (a) reacting magnesium and L-glutamic acid solution in a reactor vessel to provide hydrogen...
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WO/2008/086661A1 |
A process for synthesizing novel side chain of taxol or docetaxel and its derivatives, in which the side chain of taxol or docetaxel and its derivatives is obtained through the following reactions: resolving epoxy acid by using substitut...
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