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WO/2008/083967A2 |
The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, p...
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WO/2008/080138A1 |
A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The pr...
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WO/2008/065109A1 |
The invention relates to a process for the production of an amino acid having at least one secondary or tertiary amino group and three or more carboxyl groups or its salt with less than an equivalent of alkaline metal based on the number...
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WO/2008/056827A1 |
Disclosed is a process for producing a betaine such as carnitine in a high yield, which can prevent the occurrence of any side reaction to a larger degree compared to a conventional process. Specifically disclosed is a process for produc...
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WO/2008/055843A1 |
The invention relates to preparation of high purity 3-carboxy-N,N,N-trimethyl-1-propanaminium hydroxide inner salt by saponification of 3-trimethylaminiumbutanoic acid ester salt and following precipitation of inorganic salts with carbon...
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WO/2008/056768A1 |
A process for the production of metal catalyst carrying carbon/ethylenediamine composites, characterized by reacting carbon carrying a metal catalyst with ethylenediamine in water or a liquid mixture of water with a water-soluble organic...
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WO2008031567B1 |
The invention relates to a process for producing a compound according to formula (i) or salt thereof, wherein R1 and R1´ are independently hydrogen or an amine protecting group and R2 is a carboxyl group or an ester group, comprising re...
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WO/2008/049262A1 |
A bamboo shoot amino acid peptide extract, its preparation method and its use. The extract contains 10-50 wt% (based on dried sample) amino acid, which comprises 5-40 wt% free amino acid, including tyrosine, serine, aspartine, glutamic a...
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WO/2008/041571A1 |
It is intended to produce an anti-form of an optically active β-hydroxy-α-aminocarboxylic acid ester efficiently, simply and industrially advantageously. It can be achieved by directly and selectively producing an optically active β-h...
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WO/2008/039093A1 |
The invention relates to a bactericidal treatment and dehelmithsation of waste water sludge of water treatment plants. The inventive treatment method consists in using a reagent which is produced by using a product obtained by the water-...
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WO/2008/039092A1 |
The invention can be used for detoxifying sludge of waste treatment plants. The inventive method for detoxifying sludge of waste treatment plants consists in determining the content of heavy metals therein and in calculating the required...
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WO/2008/034238A1 |
A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a metal hydroxyl amino acetate. The secon...
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WO/2008/034095A2 |
Disclosed are processes for preparing a protected trifluorothreonine, or salt thereof or carboxylate derivative thereof, the process comprising: dihydroxylation of an alkene to yield a dihydroxyl compound; conversion of the dihydroxyl co...
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WO/2008/032546A1 |
A process for producing an optically active α-amino acid benzyl ester by reacting an optically active α-amino acid with benzyl alcohol in the presence of an acid, wherein the reaction is conducted using substantially no solvent and und...
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WO/2008/030112A1 |
The invention relates to methods of preparing compounds of formula (II) wherein Z represents -OR1 or -N(R2)R2a-, where R1 is lower alkylene (C1-C6), R2 is lower alkyl or H and R2a is lower alkylene (C1-C6) or H;Q is absent when R2a is H ...
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WO/2008/020532A1 |
Disclosed are: a novel crystal of 5-aminolevulinic acid phosphate having high thermal stability, a high melting point and excellent water absorption resistance; and a process for producing the crystal. Specifically disclosed are: a cryst...
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WO/2008/012974A1 |
It is intended to provide a novel optically active imidazolidinone derivative which can be generally used in synthesizing an optically active amino acid and a method whereby this derivative can be conveniently produced. It is also intend...
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WO/2008/007145A2 |
The present invention relates to a novel process for the preparation of -amino 5 acid s, such as (±)-3-(aminomethyl)-5-methyl-hexanoic acid 1, which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S)-(...
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WO/2008/004044A1 |
This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5- methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to giv...
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WO/2008/003761A1 |
The invention relates to a method for producing optically active 3-aminocarboxylic acid ester compounds. According to said method, an enantiomer mixture of a mono-N-acylated 3-aminocarboxylic acid ester, which mixture was previously enri...
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WO/2008/004115A1 |
A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetal...
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WO/2007/143152A2 |
Provided are processes for the preparation of (3S)-cyano-5-methylhexanoic acid, an intermediate in the synthesis of (S)-pregabalin.
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WO/2007/137799A1 |
The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-l-phenylpropyl)-4-(hydroxymethyl) phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formul...
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WO/2007/139933A2 |
Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.
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WO/2007/132119A1 |
The invention relates to a method for the synthesis of an ester compound of the trans-4-amino-cyclohexane carboxylic acid of formula (I). Said method is characterised in that the ester (I) is obtained, in the form of a salt or otherwise,...
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WO/2007/132689A1 |
[PROBLEMS] To provide a process for production of [18F]FACBC, which can reduce the amount of an impurity produced during the process. [MEANS FOR SOLVING PROBLEMS] A process for production of a radioactive fluorine-labeled organic compoun...
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WO/2007/128463A1 |
The present invention relates to a process for the deprotection of protected amine compounds, wherein the protected amine compound is contacted with an electrophilic oxidating agent that is optionally formed in situ, said electrophilic o...
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WO/2007/129286A1 |
A one pot process for preparing l-(aminomethyl)-cyclohexaneacetic acid or pharmaceutically acceptable salts thereof comprises the steps of hydrolysing 1-cyanocyclohexaneacetic acid ethyl ester with a potassium, sodium or lithium hydroxid...
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WO/2007/119302A1 |
Disclosed is a method for production of a phosphate salt of an amino acid or an ester of the amino acid, such as a phosphate salt of δ-aminolevulinic acid. The method is characterized by allowing the amino acid, the ester of the amino a...
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WO2007088346B1 |
A continuous process for forming an anthranilic acid which includes treating in a first step a mixture comprising a carbonate salt and an anthranilic acid salt of the formula (I) where R is selected from hydrogen and one or more substitu...
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WO/2007/119984A1 |
The present invention provides the salicylic acid derivative compound or its pharmaceutically acceptable salt useful for treating several diseases, a pharmaceutical composition containing the compound or its salt, and a treating or preve...
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WO/2007/115799A1 |
A process is proposed for preparing creatine, creatine monohydrate or guanidinoacetic acid, wherein N-methylethanolamine or ethanolamine is first catalytically dehydrogenated, in each case in alkaline solution, and the sarcosinate or gly...
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WO/2007/100086A1 |
Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclose...
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WO/2007/097336A1 |
A process by which (2R,3R)- and (2S,3S)-3-phenylisoserine derivatives useful as an intermediate for medicines can be easily and industrially advantageously produced. A salt of (2R,3S)- or (2S,3R)-3-phenylglycidic acid is reacted with amm...
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WO/2007/084545A1 |
A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacti...
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WO/2007/066828A1 |
Disclosed are a process for producing a compound (IIa) shown below or a compound (IIb) shown below; a process for producing a compound (IIIa) shown below or a compound (IIIb) shown below; a process for producing a compound (Va) shown bel...
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WO/2007/062865A1 |
The present invention relates to a process for the preparation of the ACE inhibitor (2S, 3aS, 7aS) -1- ((2S) -2- (((1S) -1- (ethoxycarbonyl)butyl)amino) -1-oxopropyl) octahydro-lH-indol-2- carboxylic acid and of pharmaceutically acceptab...
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WO/2007/064663A2 |
A method of producing gabapentin (l-amino-methyl)-l-cyclohexaneacetic acid) from its hydrochloric or hydrobromic salt or mixtures thereof in an anhydrous medium, the method consisting of: - dissolving gabapentin hydrochloride or hydrobro...
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WO/2007/063974A1 |
Disclosed is a process for hydrogenating an aromatic ring of an aromatic ring compound which proceeds under comparatively mild conditions. This process for hydrogenating an aromatic ring of an aromatic ring compound can be carried out in...
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WO/2007/060176A1 |
The present invention relates to a process for preparing vinyl carboxylates by reacting a carboxylic acid with an alkyne compound in the presence of a catalyst which is selected from carbonyl complexes, halides and oxides of rhenium, of ...
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WO/2007/060917A1 |
The invention provides organic compounds containing Group 13 metals which compounds are easily handleable and stable even in the atmosphere or in the presence of water and a process for producing the compounds easily in high yield and at...
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WO/2007/052778A1 |
A method in which with respect to microwave wavelength, a wavelength shift is carried out with the use of a magnetic material, aluminum oxide, etc., and in which matching of the region of shifted wavelength to the heat absorption wavelen...
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WO/2007/045593A2 |
Compounds useful in the treatment of disorders characterised by deposits of amyloid aggregates are herein described together with pharmaceutical compounds containing the same. In particular the compounds of the present invention are thos...
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WO/2007/039522A2 |
The invention relates to a sulphonic acid salt of an amino acid alkyl ester. The invention further relates to a process for the esterification of an organic acid into the corresponding organic acid ester comprising bringing the organic a...
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WO/2007/035789A1 |
The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5- methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(lR)- l-phenylethyl]amino} ethyl)hexanoic acid.
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WO/2007/034673A1 |
A process for producing 5-aminolevulinic acid hydrochloride crystals which comprises: adsorbing the 5-aminolevulinic acid contained in a crude 5-aminolevulinic acid solution onto a cation-exchange resin; subsequently desorbing the acid w...
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WO/2007/034812A1 |
Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase afte...
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WO/2007/035890A1 |
The invention encompasses processes for the synthesis of (S)-(+)-3- (aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.
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WO/2007/034909A1 |
Disclosed is a (3R,5R)-7-amino-3,5-dihydroxyheptanoic acid derivative which is useful as an intermediate for a pharmaceutical. A (3R,5R)-7-amino-3,5-dihydroxyheptanoic acid derivative or a salt thereof can be produced by a process compri...
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WO/2007/034064A1 |
The invention relates to a method for the continuous preparation of an α-amino acid having general formula (I) from the corresponding cyanhydrin of α-amino acid having general formula (II), in which R and R', which may be identical or ...
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