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WO/2011/061341A1 |
The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given tempera...
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WO/2011/054874A1 |
The present invention relates to a novel method for the production of 2- amino-6-ethylbenzoic acid wherein7-amino-3-methylphtalide or 7-amino-3- hydroxy-3-methylphtalide is reduced to 2-amino-6-ethylbenzoic acid in water or in a mixture ...
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WO/2011/051071A1 |
The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.
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WO/2011/048535A1 |
The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently r...
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WO/2011/045266A1 |
The invention relates to a method for producing a powder containing one or more complexing agent salts of the general formula (I), starting from an aqueous solution, containing the one or more complexing agent salts at a concentration of...
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WO/2011/046007A1 |
Provided is a process for preparing easily and efficiently an intermediate compound for use in the synthesis of a gadolinium complex which has a substituent capable of improving retention in blood or organ specificity. Also provided is a...
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WO/2011/039432A1 |
The method according to the invention consists in reacting an aqueous solution of a basic amino acid and a solution of O-acetylsalicylic acid in a water-miscible organic solvent. The amino acid has a slight deficiency in relation to stoi...
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WO/2011/035725A1 |
Disclosed are sitagliptin intermediates, preparation methods and uses thereof. Said preparation methods are that compound of formula (I) is prepared by Grignard reacting compound of formula (II), trifluorobromobenzene and Grignard reagen...
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WO/2011/023382A2 |
The invention relates to a method for producing a cyristalline solid from glycine-N,N- diacetic derivatives (e.g. MGDA) with sufficiently reduced hygroscopicity, characterised in that at least one crystalline compound of formula (I) is p...
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WO/2011/024691A1 |
A process for the preparation of optically active ethyl 1-amino-2-ethenylcyclopropanecarboxylate represented by formula (3), an enantiomer thereof, or acid addition salts of the same, which comprises a step of reacting a mixture containi...
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WO/2011/016052A2 |
The invention relates to a process for preparing a compound of formula (I): wherein said process comprises hydrogenation of a compound of formula (II): under alkaline conditions, wherein R represents hydrogen or a labile group capable of...
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WO/2011/003193A1 |
The present disclosure includes compounds of Formula I: wherein R1-R3, Ar, and n are as defined herein, and methods for the quantification of carboxylic acids in samples, specifically biological samples, using the compounds of Formula I....
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WO/2011/003063A2 |
Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partia...
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WO/2011/001976A1 |
Disclosed is a method for producing Droxidopa or a pharmaceutically acceptable salt thereof which involves a step for reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by formula (1) with methylamine, whereby threo-...
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WO/2010/150886A1 |
Disclosed is a method for producing an aminomalonic acid ester or an inorganic acid salt thereof, which is characterized in that a malonic acid ester and sodium nitrite are reacted with each other in the presence of an acid in an aqueous...
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WO/2010/150887A1 |
Disclosed is a method for producing an aminomalonic acid ester represented by general formula (2) or general formula (3) or a salt thereof, wherein a compound represented by general formula (1) is subjected to a hydrogenation reduction r...
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WO/2010/149308A2 |
The present invention relates to new substituted benzoxa(thia)zoles, methods for producing the compounds, agents containing these compounds, and the use thereof as biologically active compounds, in particular for fighting harmful microor...
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WO/2010/139755A1 |
The present invention relates to a process comprising the reaction of a cyanide with an amino acid and an aldehyde, characterized in that the cyanide is a cyanide salt, the amino acid is aspartic acid and/or glutamic acid in the acidic f...
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WO/2010/133618A1 |
The invention relates to a process for preparing a powder comprising one or more derivatives of glycine-N,N-diacetic acid and/or one or more derivatives of glutamine-N,N-diacetic acid having a degree of crystallinity of ≥ 30%, proceedi...
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WO/2010/133617A1 |
The invention relates to a method for producing a spray powder containing one or more glycine-N,N-diacetic acid derivatives of the general formula (I) MOOC-CHR-N(CH2COOM)2 (I), R standing for C1-12 alkyl and M standing for alkali metal, ...
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WO/2010/131921A2 |
The present invention provides a method for producing an alkyl amine derivative, which produces hardly any impurities and gives high purity and which allows high-volume production.
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WO/2010/131025A1 |
The present invention relates to novel processes for the preparation of enantiomerically enriched β -amino acid derivatives such as β -amino esters useful for the synthesis of enantiomerically enriched biologically active molecules suc...
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WO/2010/128212A1 |
The invention relates to the use of solid betaine for de-icing and/or preventing slipperiness. The solid betaine comprises at least one non-betaine compound affecting water and/or moisture movement in said solid betaine. The invention fu...
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WO/2010/126086A1 |
Disclosed is a technique for efficiently producing a large amount of an amide compound at low cost, using an α,β-unsaturated carboxylic acid as a starting material, said amide compound being suitable for solvents and cleaning agents.
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WO/2010/121904A1 |
The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the correspond...
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WO/2010/112550A1 |
The invention relates to a method for producing a radiopharmaceutical. In said method, steps (A), (B), and (C) are performed. In a step (A), an H-Li exchange is made by adding an alkyllithium to an isocyanide, wherein the α-H atom of th...
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WO2010110361A1 |
Disclosed is a method for producing a compound which has an excellent activity as an a2d ligand. Specifically disclosed is a method for producing a compound represented by general formula (I) or a salt thereof through optical resolution....
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WO/2010/109490A1 |
The present invention provides an enantioselective composite membrane useful for separation of optical isomers and the process for the preparation thereof. The invention further provides a membrane based pressure driven separation proces...
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WO/2010/105363A1 |
Macrocyclization of amino acids or linear peptides upon reaction with amphoteric amino aldehydes and isocyanides is provided.
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WO/2010/089095A1 |
The present invention discloses a process for the recovery of betaines from electrodialysis (ED) waste streams, whereby said waste streams are treated with a pressure driven membrane process.
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WO/2010/070228A9 |
The invention relates to a process for the ammonolysis of 11‑bromoundecanoic acid, carried out under conditions that make it possible to limit secondary reactions that produce impurities, especially secondary amine type reactions, whil...
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WO/2010/090031A1 |
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-
pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for pr...
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WO/2010/089512A1 |
The invention relates to a method for synthesizing ω-aminoalkanoic acids or esters thereof from unsaturated natural fatty acids, passing through a monounsaturated dinitrile intermediate compound. The method of the invention is simple to...
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WO/2010/089094A1 |
The present invention discloses a process for the production of a fatty acid/L-carnitine derivative, whereby the educts are reacted in the presence of monochloroacetic acid.
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WO/2010/081410A1 |
Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid and intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2010/071988A1 |
Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 subs...
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WO/2010/070368A1 |
The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-500C in the presence of Pd/C under 0....
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WO/2010/069397A1 |
The present invention concerns a process for the preparation of the salt diclofenac epolamine comprising the following steps: a) reacting 1 -(2,6-dichlorophenyl)-2-indolinone with a base selected from sodium hydroxide or potassium hydrox...
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WO/2010/067912A1 |
The present invention relates to a method for preparing biphenyl benzoic acid derivatives. The method for preparing biphenyl benzoic acid derivatives of the present invention is industrially advantageous in that: undesired intermediates ...
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WO/2010/061403A2 |
A process for the preparation of (S)-pregabalin of formula I containing cyanide ion content less than 5 ppm or free from the cyanide ion,by extracting its cyano diester intermediate of formula III, wherein R 1 and R 2 are the same or dif...
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WO/2010/061621A1 |
Disclosed is a method for manufacturing, efficiently and with high yield, a trans-{4-[(alkyl amino) methyl] cyclohexyl} acetic ester which is useful as a starting material compound for the manufacture of medicines and the like, said meth...
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WO/2010/062590A2 |
The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.
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WO/2010/058577A1 |
Disclosed is a method for producing an unsaturated aminocarboxylic acid derivative, which is useful as a pharmaceutical raw material, at low cost. Specifically, an unsaturated aminocarboxylic acid derivative is produced by hydrolyzing a...
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WO/2010/058206A1 |
A method of making a phenylethylamine of formula (B): wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduc...
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WO/2010/055162A1 |
Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, IV and VIII.
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WO/2010/055273A1 |
The invention relates to a method for the synthesis of ω-amino alkanoic acids or of esters thereof starting from unsaturated natural fatty acids passing through an ω-unsaturated nitrile intermediate compound. The method which is the su...
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WO/2010/053050A1 |
Disclosed is an O-alkylserine which is useful as a pharmaceutical intermediate. Also disclosed is a process for producing an N-benzyl-O-alkylserine, which is a compound useful for the production of the O-alkylserine, on an industrial sc...
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WO/2010/047318A1 |
Disclosed are novel helicene derivative, axially asymmetric amino acid, amine or aminoalcohol derivative, and azaperylene derivative. The inventors have created compounds each represented by general formula (I), (I'), (II), (II') or (III...
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WO/2010/045352A2 |
Methods of producing aminonitrobenzoic acids are disclosed. A dinitrobenzoic acid may be reduced to an aminonitrobenzoic acid. In some specific embodiments, 2,6- dinitrobenzoic acid may be converted to 2-amino-6-nitrobenzoic acid. An end...
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WO/2010/041739A1 |
The issue is to provide a method to obtain optically active vinyl-cyclopropane carboxylic acid derivatives with high yield and high optical purity using starting materials that are safe and easily acquired at a low cost. An additional is...
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