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WO/2014/085138A1 |
A method for preparation of 2-alkyl-1,2-benzisothiazolin-3-ones from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolin-3-one with a dialkyl carbonate in the presence of a base.
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WO/2014/054294A1 |
[Problem] To provide an industrially preferable method for manufacturing an isothiazole compound, particularly 3,4-dichloro-5-cyanoisothiazole. For example, to provide a safer industrial manufacturing method by avoiding simultaneous use ...
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WO/2014/020350A1 |
Compounds of formula (I) or pharmaceutically acceptable salts, solvates or hydrates thereof wherein P, Q, X, Y, R1, R2, R3, R10, R11, and R12 are as defined in the claims, and the use those compounds in medicine.
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WO/2014/020351A1 |
N-(4-carbamimidoylphenyl)-amide derivatives having utility in therapy as PAR2 receptor antagonists.
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WO/2014/009447A1 |
Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of maki...
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WO/2014/001120A1 |
The present invention provides compounds of formula (I). The invention also provides methods of controlling insects, acarines, nematodes or molluscs using the compounds of formula 1.
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WO/2014/001121A1 |
The present invention provides compounds of formula (I) and their use in methods of controlling insects, acarines, nematodes or molluscs.
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WO/2013/187965A1 |
Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as subs...
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WO/2013/129342A1 |
Provided is an acrylic acid ester derivative which can exhibit excellent lithographic properties including LWR when used as a constituent unit for a high-molecular-weight compound to be contained in a photoresist composition for a semico...
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WO/2013/118138A1 |
The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceu...
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WO/2013/101954A1 |
This invention is directed to a compound of Formula I Formula I or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, n, X1, X2, L1, and L2 are as defined herein. The compounds of Formula I are useful as receptor tyrosine...
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WO/2013/092943A1 |
The present invention relates to isothiazoline compounds of formula (I) wherein the variables are as defined in the claims or the description, which are useful for combating or controlling invertebrate pests, in particular arthropod pest...
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WO/2013/090227A1 |
The present invention relates to novel benzisothiazol-3(1 H)-one-5-sulfonyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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WO/2013/060766A1 |
Sodium sulfide hydrate is at least partially dehydrated by heating with N-methyl 2-pyrrolidone. 2-Chlorobenzamide is added to the mixture which is heated further. The mixture is cooled and treated with aqueous hydrogen peroxide to give t...
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WO/2013/056684A2 |
The present invention relates to a thiazole derivative, as represented in formula I, as a DHODH inhibitor and a use thereof. The compound of the present invention can be used for treating or preventing DHODH-mediated diseases, including,...
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WO/2013/037626A1 |
The present invention provides compounds of formula (I) wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z formula (II); Y1, Y2, Y3 and Y4 are independently of each other C-H, C-R5, or nitrogen;G1is oxygen or sulf...
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WO/2013/025733A1 |
Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one ...
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WO/2013/014665A1 |
The present invention relates to a process for the preparation of Lurasidone or a pharmaceutically acceptable salt thereof, a compound useful for the treatment of schizophrenia and bipolar disorder. The present invention further relates ...
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WO/2012/176856A2 |
To provide a novel pesticide. The present invention provides a compound represented by the formula (I) or its salt, and a pesticide containing it as an active ingredient: (I) wherein each of R1 and R2 is a hydrogen atom, a halogen atom, ...
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WO/2012/153341A1 |
The present invention relates to a new process for the preparation of 1- [4-[3-[4-(6-fluoro- 1,2-benzisoxazol-3-yl)- l-piperidinyl]propoxy]-3- methoxyphenyl]- ethanone (Iloperidone) and salts thereof. The synthetic process comprises the ...
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WO/2012/147516A1 |
[Problem] To provide a GPR40 activating agent having as an active ingredient a novel compound having a GPR40 agonist action, or a salt thereof, a solvate of the compound or salt, or the like; in particular, an insulin secretagogue or an ...
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WO/2012/147518A1 |
[Problem] To provide a GPR40 activating agent having as an active ingredient a novel compound having a GPR40 agonist action, a salt thereof, a solvate of the compound or salt, or the like; in particular, an insulin secretagogue or an age...
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WO/2012/142671A1 |
The present invention provides compounds of Formula (I): and salts, racemates, isomers, diastereoisomers, enantiomers, hydrates, solvates, N-oxides, pharmaceutically acceptable derivatives or prodrugs thereof. Also provided the use of th...
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WO/2012/140254A1 |
The invention relates to a rubber composition for the production of tyres, containing one or more diene elastomers, one or more reinforcing fillers and a vulcanisation system. The composition is characterised in that the vulcanisation sy...
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WO/2012/136120A1 |
An aryl acrylamide compound, or a geometric isomer thereof, or a pharmaceutically acceptable salt or hydrate thereof as represented by Formula I, a preparation method therefor, and a pharmaceutical composition containing the compound. Th...
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WO/2012/127969A1 |
The present invention provides a method for producing 1,2-benzisothiazol-3-one compounds by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, the method being characterized in comprising a ...
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WO/2012/127996A1 |
The present invention provides a method for producing a 1,2-benzisothiazol-3-one compound whereby the alkyl halide by-product that is generated when a 2-(alkylthio)benzonitrile compound and a halogenation agent are reacted in the presenc...
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WO/2012/119941A1 |
The invention relates to compounds of Formula (II) and their use in theraphy as peptidase inhibitors.
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WO/2012/102459A1 |
The present invention provides a compound of chemical formula I as novel benzothiazole and benzisothiazole derivatives having a 5-HT6 receptor inhibitory activity or pharmaceutically acceptable salts, a preparation method thereof, and a ...
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WO/2012/101199A1 |
Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula (I), wherein A, D, E, G, R10 R11, R30 R40 R50 and R60 have the meanings indicated ...
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WO/2012/066366A1 |
The invention relates to non-sulfonic acid type new rasagiline salts, a process for the preparation thereof, pharmaceutical compositions containing said salts and the use thereof for the treatment or prophylaxis of various diseases, name...
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WO/2012/046869A1 |
[Problem] To provide a GPR40 activator, particularly an insulin secretion stimulator or a prophylactic and/or therapeutic agent for diabetes, obesity or the like, which contains a novel compound having a GPR40 agonistic activity, a salt ...
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WO/2012/035061A1 |
A new process for the diamination of alkenes is provided, as well as the new compounds prepared thereof. A process for the preparation of the primary amines obtained from the diaminated alkenes of the provided preparation process is also...
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WO/2012/035123A1 |
Arylsulphonamide derivatives of formula (I) and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of disorders of the central nervous system.
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WO/2012/033177A1 |
The objective of the present invention is to provide: an ink which contains a heterocyclic azo dye that has excellent solubility in a low-polarity solvent, high light absorption coefficient and high light resistance; and a dye. The objec...
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WO/2012/031407A1 |
Provided is a preparation method of isothiazolinone and derivatives thereof in a gas carrier, which comprises: mixing a starting compound with a gas carrier in the absence of solvents, and then transporting the mixture to react with a ha...
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WO/2012/028563A1 |
The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalam
ides of formula (I) having BACE2 inhibitory activity and their use as therapeutically active substances, their manufacture and pharmaceutical c...
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WO/2012/031298A2 |
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-ne...
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WO/2012/010316A1 |
The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)- phenol (component a) and at least one acid component (b1 ) or at least one acid component (b2), wherein the salt or cocrystal of component (a) a...
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WO/2011/140680A1 |
The present invention discloses compounds of formula (I), isomers, pharmaceutical salts or solvates thereof. The present invention also discloses a composition comprising the compounds of formula (I), isomers, pharmaceutical salts or sol...
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WO/2011/136292A1 |
Provided is a novel low molecular weight compound which inhibits the production of inducible MMPs, in particular MMP-9, rather than the production of constitutive MMP-2. Also provided is a prophylactic and/or therapeutic agent for an aut...
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WO/2011/131975A1 |
This invention relates to piperidine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
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WO/2011/125423A1 |
Disclosed is a method for producing 3-halo-1,2-benzisothiazoles represented by general formula (2), which is characterized in that 1,2-benzisothiazol-3-ones represented by general formula (1) and a thionyl halide are caused to react with...
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WO/2011/116356A2 |
The disclosure provides compounds and compositions, and methods of using these compounds and compositions, as positive ailosteric modulators of the melabotropic glutamatc subtype 2 (mGlu2) receptor, and for treating CNS disorders associa...
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WO/2011/116355A2 |
The disclosure provides new compounds and compositions thereof, and methods for treating or ameliorating a disorder relating to CDG-Ia. In particular, the disclosure provides benzoisothiazolone inhibitors of PMI, which have been synthesi...
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WO/2011/092611A1 |
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, met...
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WO/2011/078371A1 |
Disclosed are a GPR40 activator having as an active ingredient a compound with a novel GPR40 agonist effect, a salt thereof, or a solvate of either; disclosed in particular are an insulin secretagogue, and a prophylactic and/or therapeut...
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WO/2011/064141A1 |
The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R2, R3, R4, R5, and R6 are as defined herein.
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WO/2011/062864A2 |
Inhibitors of Nox enzymes, such as Noxl, Nox2, and Nox3, and methods of making and using such compounds are describe herein.
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WO/2011/047432A1 |
The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions cont...
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