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WO/2018/104305A1 |
Substituted aromatic sulfonamides of formula (I) which are antagonists or negative allosteric modulators of P2X4, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a ph...
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WO/2018/102419A1 |
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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WO/2018/071327A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2018/064119A1 |
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
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WO/2018/029150A1 |
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...
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WO/2018/007323A1 |
The present disclosure relates to fungicidal active compounds of formula (I), more specifically to benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, part...
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WO/2017/162157A1 |
Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method therefor, and a pharmaceutic...
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WO/2017/128896A1 |
Disclosed are an FXR agonist and a preparation method and use thereof, in particular relating to the compound having the structure of formula (I), a stereisomer or a pharmaceutically acceptable salt thereof. The series of compounds can b...
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WO/2017/129122A1 |
Provided in the present invention are isothiazole oxime ether strobilurin derivatives, a preparation method for same, and uses thereof. The present invention relates to 3,4-dichloroisothiazole oxime ether strobilurin derivatives, which h...
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WO/2017/115134A1 |
A process for preparing, 1,1,3-Trioxo-l,2-benzothiazole-6-carboxamide of formula (I) comprising: reacting 2-chlorosulfonyl-terephthalic acid dialkyl ester of formula (II) with ammonia (N H3) or ammonium containing-salt; wherein R represe...
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WO/2017/115137A1 |
A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid...
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WO/2017/078927A1 |
Novel compounds having a formula (I), embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a s...
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WO/2017/070157A1 |
This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, disele...
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WO/2017/064277A1 |
The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD interaction.
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WO/2017/027309A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I), as follows: wherein R1, R2, R4, W, X, Y, and G, are def...
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WO/2017/027312A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (III); wherein R1c, R2C, R4C, Wc, Yc, Zc and Gc, are defined...
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WO/2017/027310A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula II.
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WO/2017/024229A1 |
A process for the stereoselective synthesis of chiral 3-heterocyclyl-1,2-dihydroxy cyclohexanes is disclosed. The process involves reacting a tricyclic nitrogenous heterocycle with an allyl carbonate in the presence of a chiral palladium...
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WO/2016/116525A1 |
The invention relates to organic molecules, in particular for use in optoelectronic components, such as OLEDs. According to the invention, the organic molecule has a structure of formula 1. In formula 1, n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9...
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WO/2016/108282A1 |
A compound represented by general formula (III), and the use of a tautomer or stereoisomer of said compound, or a pharmacologically acceptable salt or solvate thereof, as a treatment for gout or hyperuricemia. (III) (In the formula, R1a,...
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WO/2016/102435A2 |
The present invention relates to novel isothiazolamide derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds for controlling harmful m...
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WO/2016/102420A2 |
The invention relates to the technical field of the herbicides and/or plant growth regulators. Specifically, the invention primarily relates to novel isothiazolamides, and compositions comprising said novel isothiazolamides. Further, the...
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WO/2016/085655A1 |
A method for preparation of 2-methyl-1,2-benzisothiazolin-3-one from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolin-3-one with an alkali metal hydroxide and dimethyl sulfate.
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WO/2015/195478A1 |
Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII), respectively wherein, R1 and R2 are individually selected from hydrogen, alkyl, substit...
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WO/2015/170775A1 |
[Problem] To provide a novel substituted azole compound having a GPR119-activating activity and useful particularly for the prevention and/or treatment of diabetes and obesity. [Solution] Provided are: a novel substituted azole compound ...
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WO/2015/151491A1 |
[Problem] To provide an industrially preferred method for producing an isothiazole compound, in which the simultaneous use of N,N-dimethylformamide or the like and chlorine is avoided. [Solution] A method for producing an isothiazole com...
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WO/2015/143653A1 |
The present invention is directed to substituted five membered heteroaryl benzamide compounds compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of...
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WO/2015/143652A1 |
The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula(I) which are tropomyosin-related kinase(Trk)family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, ...
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WO/2015/138969A1 |
Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subjec...
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WO/2015/134039A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
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WO/2015/117912A1 |
Compounds of formula (I), wherein (II) is a five-membered, aromatic ring system which may contain 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur,and where each ring system may not contain more than ...
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WO/2015/106959A1 |
The invention relates to a method for producing N-alkyl-l,2-benzisothiazolin-3-ones according to general formula (I), wherein R2 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a...
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WO/2015/095807A1 |
The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method comprises administering to the subject an effective ...
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WO/2015/081920A1 |
A new method of synthesis of lurasidone, the substance of the chemical name (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo [d]isothiazol-3-yl)piperazin-1 -yl)methyl)cyclohexyl)methyl)-hexahydro-1H-4,7-methanoisoind
ole-1,3(2H)-dione of structu...
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WO/2015/055293A1 |
The invention relates to a method for the preparation of 1,2-benzisothiazolin-3-ones, comprising the reaction of 2-(alkylthio)benzonitrile with a peroxo compound under the formation of 2-(alkylsulfoxy)benzonitrile and the subsequent reac...
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WO/2015/051362A1 |
Multifunctional chelators, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
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WO/2015/043995A1 |
N-alkylated 1,2-benzisothiazolin-3-ones can be prepared in good yield and good selectivity by reaction of the lithium salt of l,2-benzisothiazolin-3-one with an electrophilic alkylating agent.
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WO/2015/011244A1 |
The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin- 2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
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WO/2014/206907A1 |
The present invention relates to naphthyl-or isoquinolinyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling inver...
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WO/2014/206910A1 |
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in...
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WO/2014/206908A1 |
The present invention relates to isothiazoline compounds substituted with a carbobicyclic group of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling inve...
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WO/2014/180165A1 |
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D3 receptor, 5-HT1A receptor and 5-HT2A...
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WO/2014/181788A1 |
The present invention provides: a novel α-substituted glycineamide derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition containing the α-substituted glycineamide derivative or a pharmacologically acce...
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WO/2014/181287A1 |
The present invention provides heterocyclyl compounds of formula I, isotopic forms, stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, solvates, N- oxides, S-oxides and polymorphs thereof, and processes for their p...
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WO/2014/173716A1 |
Sodium sulfide hydrate is at least partially dehydrated by heating with N-methyl 2- pyrrolidone. 2-Chlorobenzamide is added to the mixture which is heated further. The mixture is cooled and treated with aqueous hydrogen peroxide to give ...
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WO/2014/159054A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: Formula (I) wherein Y, R1,...
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WO/2014/079935A9 |
The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, G1, n, A1, A2, A3, and A4 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insectici...
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WO/2014/113485A1 |
Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one ...
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WO/2014/086098A1 |
Disclosed are a cyclohexane amine compound and an application thereof for anti-schizophrenia drugs. The cyclohexane amine compound of the present invention has high affinity for a dopamine D3 receptor and 5-ΗΤ1Α, and a lead compound h...
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WO/2014/085138A1 |
A method for preparation of 2-alkyl-1,2-benzisothiazolin-3-ones from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolin-3-one with a dialkyl carbonate in the presence of a base.
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