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WO/2000/001838A2 |
The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervar...
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WO/1999/065871A2 |
This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thioles...
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WO/1999/062890A1 |
The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X?1¿, R?1¿, R?2¿ and R?3¿ are as defined herein. The invention also relates to pharmaceutical ...
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WO/1999/059947A1 |
This invention relates to a process for the synthesis of ethers or esters comprising reacting an alcohol or carboxylic acid with an organic halide to produce an ether or ester respectively and a hydrogen halide, wherein further organic h...
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WO/1999/058122A1 |
The present invention relates to novel fatty acid analogues of the general formula (I): CH¿3?-[CH¿2?]¿$i(m)?-[x¿$i(i)?-CH¿2?]¿$i(n)?-COOR, as defined in the specification, which can be used for the treatment and/or prevention of di...
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WO/1999/058121A1 |
The present invention relates to novel fatty acid analogous of the general forumla I: CH¿3?-[CH¿2?]¿m?-[x¿i?-CH¿2?]¿n?-COOR, as defined in the specification, which can be used for the treatment and/or prevention of obesity, fatty l...
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WO/1999/058123A2 |
The present invention relates to novel fatty acid analogues of the general formula (I): CH¿3? -[CH¿2?]¿$i(m)? - [x¿$i(i)? - CH¿2?]¿$i(n)? - COOR, wherein $i(n) is an integer from 1 to 12, and wherein $i(m) is an integer from 0 to 2...
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WO/1999/058120A1 |
There is disclosed a use of non-$g(b)-oxidizable fatty acid analogues of the general formula (I): Alkyl-X-CH¿2?COOR, wherein alkyl represents a saturated or unsaturated hydrocarbon group of from 8-22 carbon atoms, X represents O, S, SO,...
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WO/1999/054295A1 |
A process for preparing 4-hydroxy indoles and 4-hydroxy carbozoles useful as intermediates for preparing compounds that are useful for inhibiting SPLA¿2? and novel intermediates.
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WO/1999/051570A1 |
Disclosed is an anion-complexing compound (I) wherein R1 and A represent an aromatic 6-ring, Y' represents a -NHC(X)NH-group, and Y' represents a rest selected from the group -NHC(X')-, -C(X')NH- and -NHC(X')NH-, wherein X and X', indepe...
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WO/1999/050238A1 |
Compounds having a urea structure as the basic structure and carrying sulfur and amide bonds in side chains. It has been found out that these compounds have pharmacological effects, in particular, a TNF-$g(a) production inhibitory effect...
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WO/1999/046239A1 |
An imine fixed to a resin characterized in that it is represented by the following formula: P-Q-N=CH-R wherein P represents a main chain of a polymer constituting the resin, Q represents a hydrocarbon side chain optionally substituted wi...
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WO/1999/044989A1 |
The present invention relates to compounds of formula (I) wherein X is a -CO¿2?H or -CONHOH group; Y and Z are independently sulphur or oxygen, at least one being sulphur; R¿1? is hydrogen, hydroxy, (C¿1?-C¿6?)alkyl, (C¿2?-C¿6?)alk...
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WO/1999/042438A1 |
It is described a process for preparing 2-acethylthio-3-phenyl-propionic acid and the salts thereof starting from 2-bromo-3-phenyl-propionic acid and potassium thioacetate in an organic solvent and in the presence of a phase transfer cat...
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WO/1999/042439A1 |
The invention relates to novel thiobenzamides of general formula (I) in which R?1¿ to R?4¿ have the meaning indicated in the description, and their hydrates, solvates and physiologically tolerable salts, optically active forms, racemat...
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WO/1999/040787A1 |
In accordance with the present invention, there are provided modified forms of pharmacologically active agents (e.g., anti-inflammatory agents) which provide increased/prolonged circulating levels of the active agent, thereby allowing ad...
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WO/1999/040056A1 |
The present invention concerns enzymatic aromatic hydroxylation-activated prodrugs, particularly anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the enzyme CYP1B1.
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WO/1999/036384A1 |
Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.
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WO/1999/033830A1 |
A process for the preparation of the compound represented by chemical formulae (1, 2, 3, 4, 5, 6, 7, 8a, 8b, 9, 10) which is useful as a raw material for the preparation of antibiotics; and intermediates used for the preparation of the c...
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WO/1999/032433A1 |
The present invention provides compounds of formula (I). The present invention also provides methods of treating or preventing inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of formula (I).
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WO/1999/031144A1 |
A free radical polymerization process suitable for synthesizing polymers is disclosed. The process utilizes novel sulfur based chain transfer agents and is widely compatible over a range of monomers and reaction conditions. Novel polymer...
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WO/1999/030711A1 |
Drugs inhibiting autoimmune responses and/or potentiating normal immune responses through the augmentation of NKT cells, characterized by containing as the active ingredient compounds represented by general formula (I) or pharmaceuticall...
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WO/1999/029294A1 |
The present invention relates to compounds that are two-part molecules, and compositions containing such compounds, in which one part is designed to become covalently bonded to the skin (bonding agent) and the other part (a characteristi...
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WO/1999/028293A1 |
The invention concerns a method for making bisthioester of formula (I) in which X represents -CH¿2?CH¿2?-S-CH¿2?CH¿2?-; -CH¿2?CH¿2?- or -CH¿2?CH¿2?CH¿2?-, characterised in that it consists in reacting methacrylic anhydride (a) w...
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WO/1999/028294A1 |
The invention concerns a method for making methacrylic thioesters of formula (I) in which R represents a primary linear alkyl radical containing 3 to 12 carbon atoms, characterised in that it consists in reacting methacrylic anhydride wi...
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WO/1999/026584A2 |
Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agen...
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WO/1999/024409A1 |
Compounds of formula (I) wherein Z is S, SO or SO¿2?; Q is C=O or CHOH; Ar is phenyl or phenyl substituted by up to four identical or different substituents and agronomically acceptable salts of those compounds, are suitable for use as ...
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WO/1999/020668A1 |
The invention relates to sulfone functionalized prepolymers useful in making high index of refraction optical lenses which have superior hardness and thermal stability. The invention further relates to the resins produced from the prepol...
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WO/1999/019296A1 |
Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and...
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WO/1999/016758A1 |
The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmace...
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WO/1999/007668A1 |
Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.
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WO/1999/004778A1 |
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
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WO/1999/005099A1 |
This invention relates to the synthesis of dithiocarboxylic acid esters by reaction of bis(thioacyl) disulphides, thioacetals or vinylidene bis(thioether) with free-radicals (optionally in the presence of monomers). The invention also re...
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WO/1998/058922A1 |
Aryl-substituted and aryl and (3-oxo-1-propenyl)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invent...
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WO/1998/051277A1 |
A pyruvate compound suitable for cosmetically or dermatologically administering to the skin and for use in treating diabetic ketosis or other medical treatments. The compound includes a pyruvate selected from the goup of pyruvate thioest...
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WO/1998/050031A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic -L�2?-;...
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WO/1998/050029A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L�2?-, and (i) heterocyclic -L�2?...
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WO/1998/050030A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic-L�2?-; ...
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WO/1998/048787A1 |
The instant invention provides intermediates and processes for the preparation of compounds of formula (IV), wherein n is 0, 1, or 2; R is hydrogen or C�1?-C�4? alkyl; X?1� is hydrogen, cyano, 4-hydroxybenzoyl, 4-halobenzoyl, or 4-...
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WO/1998/047894A1 |
3-(Substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and ...
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WO/1998/043949A1 |
According to the present invention, there are provided oxime ether compounds represented by general formula (I). These compounds have excellent antifungal effect for agriculture and/or horticulture as well as excellent insecticidal and/o...
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WO/1998/042661A1 |
An organic compound is provided which contains at least one nitric oxide donor group and at least one group being, or being adapted to be converted in vivo to a free sulfhydryl group. A preferred compound contains at least one sulfhydryl...
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WO/1998/042662A1 |
Disclosed are compounds of formula (I), wherein R, R�1?, R�2?, R�3?, R�4?, A and n are as defined; pharmaceutically acceptable salts thereof; disulfides corresponding to said compounds of formula (I) wherein R�4? is hydrogen; m...
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WO/1998/040169A1 |
The present invention discloses fluorocarbon-containing surface modifying agents having an $g(v)-fluorocarbon-containing tail group and a head group for reacting or interacting with surfaces such as metal, non-metallic, ceramic, other in...
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WO/1998/040056A2 |
A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a $g(b)-lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically accepta...
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WO/1998/035937A1 |
CETP activity inhitors containing as the active ingredient compounds represented by general formula (I), prodrug compounds thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these, (wherein R represents linear...
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WO/1998/035935A1 |
Novel compounds useful as active ingredients of pesticides are disclosed. Acrylonitrile compounds of formula (I) or their salts, wherein Q is Qa, Qb, Qc or Qd, Y is =C(R�4?)- or =N-, R�1? is alkyl, haloalkyl, etc., each of R�2? and...
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WO/1998/034898A1 |
The invention relates to phenoxyacetic acid derivatives of formula (I), wherein R�1?, R�2?, Xn and A are as defined in the description, A represents a halogen atom, hydroxy, OR�3?, S(O)�k?R�3?, or a group of formula (A-1) or (A...
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WO/1998/031661A1 |
Benzamidine derivatives involving compounds represented by formulae (a) and (b) and analogs thereof or pharmaceutically acceptable salts thereof. These compounds show anticoagulant effects based on their excellent effects of inhibiting a...
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WO/1998/029383A1 |
The invention concerns 2-benzoyl-cyclohexan-1,3-diones of formula (I), in which R?1�, R?2� stand for hydrogen, nitro, halogen, cyano, rhodano, alkyl, halogen alkyl, alkoxyalkyl, alkenyl, alkinyl, -OR?5�, -OCOR?6�, -OSO�2?R?6�...
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