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WO/1998/029381A1 |
A process for the preparation of compounds of general formula (IV), (wherein R?1� and R?2� are each alkyl; Q is optionally substituted aryl, an optionally substituted heterocyclic group or mono- or di-substituted methyleneamino; X is...
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WO/1998/028258A1 |
The invention provides, as contrast signal generator in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R?1�R?2�)=CR?3�-CO-Z-A (1) and/or C(R?1�R?2�)=CR?3�-CO-Z-A-Z-CO-CR...
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WO/1998/028280A1 |
Herbicidal compounds having structure (a) are disclosed, in which: X and Y are independently selected from hydrogen, halogen, and alkyl; R is alkyl or amino; R?1� is hydrogen, alkyl, cyanoalkylsulfonyl, acyl, acyloxyacyl, alkoxycarbony...
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WO/1998/027065A1 |
The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1) Y-X-C(R')=C(R')COOR''', to methods for their preparation, to compositions comprising the compound...
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WO/1998/024761A1 |
A cross-linkable polymeric casting composition including an effective amount of an acrylic or methacrylic di- or polythiol monomer of the formula (1) wherein p is an integer of 0 or 1, M and M' are each spacer groups selected from one or...
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WO/1998/022432A1 |
Acylamino-substituted acylanilide derivatives represented by general formula (I) or salts thereof, and a pharmaceutical composition comprising the same. They have an antiandrogenic activity and are useful as a prophylactic or therapeutic...
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WO/1998/022433A1 |
Disclosed are compounds which inhibit $g(b)-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits...
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WO/1998/022430A1 |
Disclosed are compounds which inhibit $g(b)-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits...
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WO/1998/019988A1 |
Briefly, in one aspect, the present invention provides compositions of open-chain, $g(a)-branched fluoroalkylcarbonyl fluorides, and derivatives thereof.
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WO/1998/019742A1 |
This invention provides aqueous film-forming foamable (AFFF) compositions comprising one or more environmentally-friendly $g(a)-branched fluoroalkylcarbonyl group-containing surfactants.
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WO/1998/020119A1 |
The soporific activity of $i(cis)-9,10-octadecenoamide and other soporific fatty-acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of $i(cis)-9,10-octadecenoamide by FAAH le...
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WO/1998/017639A1 |
Mercapto amino acid derivatives of formula (I), wherein R is hydrogen, a salt-forming cation of an $i(in vivo) hydrolysable ester-forming group; R�1? is selected from (a) and (b) in which A is a monocyclic aryl or heteroaryl ring and B...
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WO/1998/016502A1 |
The present invention relates to compounds that are inhibitors of interleukin-1$g(b) converting enzyme that have formula (I). This invention also relates to a method of treatment of stroke, inflammatory diseases, reperfusion injury, Alzh...
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WO/1998/015525A1 |
Hydroxamic acid derivatives represented by the following general formula and useful as a matrix metalloprotease inhibitor: R-X-B-N(R?1�)-A-CO-NHOH, wherein R is an optionally substituted cyclic hydrocarbon group or the like; X is optio...
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WO/1998/015512A2 |
The invention concerns fungicidal compounds, and compositions containing them, of general formula (I) in which G is selected from the groups G1 to G9: (a) in which the different symbols represent various organic groups. The invention als...
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WO/1998/012166A1 |
A liquid-crystal compound represented by general formula (1) and having low-temperature compatibility; a liquid-crystal composition comprising the same and having low threshold voltage, high pretilt angle, high voltage retention, and low...
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WO/1998/006391A1 |
Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -C(S)NH�2?,...
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WO/1998/005634A1 |
Novel, useful and optically active 2-aralkyl-3-sulfonyloxy-1-propanols and 2-aralkyl-3-sulfonyloxypropionic acids prepared from optically active 2-aralkyl-3-acyloxy-1-propanols as the starting compound; and optically active 2-aralkyl-3-t...
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WO1998004508A1 |
Selective IgE production inhibitors which contain substances inhibiting the production of IgE in the process of the differentiation of matured B cells into antibody-producing cells and the production of the antibody thereby while not or ...
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WO/1998/003474A1 |
The invention concerns novel glyoxylic acid derivatives, a process for their preparation and their use as pesticides.
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WO/1998/003166A1 |
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of prot...
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WO/1998/003164A1 |
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteina...
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WO/1998/003475A1 |
A composition, which comprises at least one compound of formula (I), in which A�1?, A�2?, R�1? and R�2? are as defined in claim 1, or, if appropriate, an E/Z isomer, an E/Z isomer mixture and/or a tautomer thereof, in each case i...
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WO/1998/002414A1 |
N-Phenylcarbamate compounds represented by formula (1), wherein R?1� represents a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms, an alkynyl group having 3 to 5 carbon atoms, an alk...
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WO/1998/001478A1 |
This invention concerns a free radical polymerization process, selected chain transfer agents employed in the process and polymers made thereby, in which the process comprises preparing polymer of general Formula (A) and Formula (B) comp...
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WO/1997/046521A1 |
Aliphatic nitrate esters having a sulfur or phosphorus atom 'beta' or 'gamma' to a nitrate group and their congeners having efficacy as neuroprotective agents are described. Preferred nitrate esters may be synthesized by nitration of a 3...
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WO/1997/043252A1 |
The invention pertains to phenylcarbamates of formula (I), wherein X is a direct bond, O or NRa; Z is O, S or NRb; R1 is hydrogen, alkyl or alkyl halide; R2 is substituted methyl or optionally substituted alkyl, alkenyl, alkinyl or cyclo...
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WO/1997/037973A1 |
Compounds of formula (I) having MMP and TNF inhibitory activity.
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WO/1997/037974A1 |
Compounds of formula (I) having MMP and TNF inhibitory activity.
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WO/1997/035840A1 |
The invention concerns metallic salts of formula (I) which are difficult to dissolve in water, R1 and R2, which are identical or different, designating hydrogen or a lower alkyl group with between 1 and 3 carbon atoms, M being the cation...
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WO/1997/034856A1 |
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs, ethanol intoxication, or as a foodstuff. The novel pyruvate...
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WO/1997/032844A1 |
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
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WO/1997/031723A1 |
In a method of depositing a metal sulfide film on a substrate, at least one metal compound precursor comprising at least one thiocarboxylate ligand SECR and at least one solubility-improving ligand L is dissolved in a solvent to produce ...
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WO/1997/030027A1 |
A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a 'beta'-lactam antibiotic, a therapeutically effective amount of an amino acid derivative of Formula (I) or a pharmace...
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WO/1997/029086A1 |
A method for the asymmetrical synthesis of S-acylated derivatives of 2-mercaptomethyl 3-phenyl propanoic acid of formula (I) is disclosed. The method comprises the steps of (a) preparing diol (VI) by reducing a malonic ester (V) in the p...
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WO/1997/022599A1 |
5-formylthiazol is advantageously produced by reaction of a 2-halogen-malone-dialdehyde compound of formula (II), in which R stands for hydrogen, an alkali metal or an alkaline earth metal equivalent and X stands for fluorine, chlorine, ...
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WO/1997/021719A1 |
A process to make 'alpha', 'alpha'-difluoro-'beta'-hydroxy thiol esters of formula (IIIA), comprising reacting a difluoroethanethioate of formula (IVA), with a second reactant selected from the group consisting of aldehydes, ketones, aci...
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WO/1997/019052A1 |
Compounds of formula (I) where X is S, O, NR' where R' is H or alkyl of 1 to 6 carbons, or X is [C(R1)2]n where n is an integer between 0 and 2; 1; Y is a phenyl or naphthyl group, or heteroaryl group; W is a substituent selected from th...
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WO/1997/018198A1 |
The present invention relates to novel acylated 5-aminoisothiazoles of formula (I), in which R1, R2, R3, R4 and Y have the meanings indicated in the description, and to intermediate products and processes for producing these compounds an...
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WO/1997/015552A1 |
Disclosed are phenylacetic acid derivatives of formula (I) in which the substituents and the index have the following meanings: X is NOCH3, CHOCH3, CHCH3; Y is O or NR; R1, R independently of one another stand for hydrogen or C1-C4 alkyl...
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WO/1997/015551A1 |
N-[(Fluoroalkoxy)phenoxyalkyl]benzamide compounds represented by general formula (1); and agricultural and horticultural pesticides containing these compounds as the active ingredient which are useful as a nematicide, miticide, insectici...
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WO/1997/013747A1 |
The disclosure concerns oxyamino oxime ethers of formula (I), wherein: X is NOCH3, CHOCH3, CHCH3; Y is O or NZ, Z being H or alkyl; R1 is H or alkyl; R2 is cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy, m = 0, 1 or 2 and the gr...
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WO/1997/012861A1 |
Mercaptoamide derivatives of formula (I), in which Y represents CHOH, CHNH2 or C=O and the other variables are defined in the description, have therapeutic activity as metalloproteinase, TNFalpha and L-selectin sheddase inhibitors.
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WO/1997/009878A1 |
The subject invention provides arylhydrazone compounds having formula (I), wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR7, NR...
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WO/1997/009297A2 |
Aryl-substituted and aryl and (3-oxo-1-propenyl)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invent...
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WO/1997/009302A1 |
Compounds represented by general formula (I) and a pesticide containing the same as the active ingredient, wherein R represents optionally substituted alkyl; Y represents optionally substituted amino; Z represents oxygen or sulfur; Q rep...
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WO/1997/008133A1 |
Amide compounds represented by general formula (I), pharmaceutically acceptable acid-addition salts thereof and a drug comprising the same as the active ingredient, wherein R represents amino, etc.; A represents alkylene, etc.; X represe...
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WO/1997/008128A1 |
A process for producing compounds represented by general formula (1) which comprises reacting a compound represented by the general formula CH2 = CXF with a compound represented by the general formula N2CHCOR in the presence of a catalys...
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WO/1997/008139A1 |
Novel sulfur compounds represented by general formula (I) wherein n represents an integer of 0 to 2 and R represents hydrogen, vinyl, methacryloyl, vinylbenzyl, glycidyl, acryloyl or allyl, provided the case where n is 0 to R is hydrogen...
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WO/1997/008192A1 |
The present invention is directed to novel tricyclic antidepressant derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to tricyclic antidepr...
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