Acyclic or Carbocyclic Compounds

Matches 501 - 550 out of 2,851	< 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >

Document	Document Title
WO/1997/007096A1	ALKOXYACRYLIC ACID THIOL ESTERS USED AS FUNGICIDES The invention concerns novel alkoxyacrylic acid thiol esters of formula (I) in which Ar, G, R1, R2 and Z have the meanings given in the description. The invention further concerns a method for their preparation, their use as fungicides, ...
WO/1997/006133A1	HYDROXIMIC ACID DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS PESTICIDES AND FUNGICIDES Hydroximic acid derivatives have the formula (I), in which the substituents have the following meanings: X stands for CH, CHO or NO; Y stands for O or NH; Z stands for O, S or NRa; Ra stands for hydrogen, alkyl, alkenyl or alkinyl; R1 st...
WO/1997/003948A1	2-SUBSTITUTED BENZOHYDROXIMOYL DERIVATIVES, INTERMEDIATE FOR THE PRODUCTION OF THE SAME AND PESTICIDE COMPRISING THE SAME AS THE ACTIVE INGREDIENT 2-Substituted benzohydroximoyl derivatives represented by general formula (I), an intermediate for the production of the same and a pesticide or bactericide comprising the same as the active ingredient, wherein R1 represents CHO or CH2OR...
WO/1997/001530A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE IN CROP PROTECTION COMPOSITIONS Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1-C4alkyl; R2 is hydrogen, C1-C4alkyl or cyclopropyl; and in which R3 and R4 are as ...
WO/1997/000859A1	THIOAMIDES S-OXIDES FOR USE AS PESTICIDES Thioamide S-oxides of formula (I) are suitable as fungicidally, insecticidally and acaricidally active ingredients in crop protection, in which R1 is hydrogen or C1-C4alkyl, and R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl or C...
WO/1996/041869A1	CIS-9,10-OCTADECENOAMIDASE The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of cis-9,10-octadecenoamidase. Hydrolysis of cis-9,10-octadecenoamide leads to the formation of...
WO/1996/040672A1	COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS Combinatorial libraries are constructed to include aminodiol monomer subunits connected by phosphodiester, phosphorothioate, or phosphoramidate linking moieties. Combinatorial libraries of the invention feature a plurality of functional ...
WO/1996/040694A1	CARBONOTHIOATE PHOSPHOLIPID ANALOGS AS SUBSTRATE OF PHOSPHOLIPASES AND LIPASES The present invention describes carbonothiate phospholiped analogs which are novel substrates of phospholipases, lysophosphilipases and lipases. Also described is a process for producing the substrate, detecting phospholipase A2, measuri...
WO/1996/039382A1	UREA DERIVATIVES AS 5-HT ANTAGONISTS A compound of formula (I) wherein R1 is cyano, thiocarbamoyl, a group of formula (a) in which R4 is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindo...
WO/1996/034851A1	BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
WO/1996/034850A1	CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the in...
WO/1996/033179A1	THIOAMIDES DERIVATES AND THEIR USE AS INHIBITORS OF HYPER-PROLIFERATIVE CELL GROWTH The present invention features compounds and methods for inhibiting hyper-proliferative cell growth. The compounds and method are preferably used to treat patients having a hyper-proliferative cell disorder. The compounds are preferably ...
WO/1996/033164A1	NEW HYDROXIMIC ACID DERIVATIVES Hydroximic acid derivatives of general formula (I), wherein G is either G1 or G2 or G3 or G4 of the formula: R5OC=C(COOR4)-, R5ON=C(COOR4)-, R5ON=C(CONR6R7)-, R5OC=C(CONR6R7)-, X1, X2, X3 are H, halo, HO, mercapto, nitro, SCN, azido, CN,...
WO/1996/032946A1	COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii...
WO/1996/031496A1	METHADONE DERIVATIVES AND PROTEIN AND POLYPEPTIDE METHADONE DERIVATIVE CONJUGATES AND LABELS The present invention is directed to methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to methadone and methadone metabolites. Th...
WO/1996/030329A1	SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
WO/1996/030395A2	CYSTEINE PROTEASE INHIBITOR A pharmaceutical composition for inhibiting cysteine protease which comprises a compound of formula (I), wherein R1 is a hydrogen atom or an acyl group; R2, R3 and R4, same or different, are a bond, an amino acid residue or a group of th...
WO/1996/027585A1	NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP Novel amino acid derivatives having an N,N-dialkylaminophenyl group represented by general formula (I), wherein R1 represents hydrogen, lower alkyl, phenyl lower alkyl, lower alkanoyl or benzoyl, provided that the phenyl ring in the phen...
WO/1996/026185A1	REAGENT, COMPOUND AND METHOD FOR NUCLEOPHILE PERFLUOROALKYLATION, AND RESULTING DERIVATIVES A reagent comprising a compound of formula (I): Rf-M(X)(Z)n-Y-R, wherein R is a hydrocarbon radical advantageously having at most 10 carbon atoms and being selected from alkyls and aryls; Rf is a radical of formula (II): R1-(C'XI'2)m-CF2...
WO/1996/022998A1	THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY Compounds of formula (I) wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compou...
WO/1996/022987A1	PROCESS FOR THE PREPARATION OF 1-(THIOMETHYL)-CYCLOPROPANEACETIC ACID The present invention provides a novel process for the preparation of 1,1-cyclopropanedimethanonl cyclic sulfite which comprises: (a) contacting 1,1-cyclopropanedimethanol with dialkylsulfite in the presence of a base; and (b) removing f...
WO/1996/020930A1	ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Acetylenes substituted with a phenyl or heteroaryl group and with a 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group have retinoid-like biological activity. The 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group is substitute...
WO/1996/019446A1	'beta'-CARBOXY SULFONAMIDE ACAT INHIBITORS 'beta'-Carboxy sulfonyl compounds of formula (I), wherein R1 is aryl, R3 is hydrogen or alkyl, R3 and R4 are hydrogen or alkyl, Y is -O-, -S-, or -NR2-, and R5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acy...
WO/1996/018372A2	CATIONIC AMPHIPHILES AND PLASMIDS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOLECULES Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or ac...
WO/1996/018644A1	AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS The present invention discloses peptide aldehydes of formula (I) which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them a...
WO/1996/017840A1	HETEROCYCLYL SUBSTITUTED HYDROXYACETAMIDE DERIVATIVES AS FONGICIDES Compounds of formula (I) wherein Q is optionally substituted heterocyclyl; Z is optionally substituted hydroxy or mercapto; E is (i) CO--N(R2), (ii) CS--N(R2) or (iii) C(SR2) = N; W is O, N(R3), optionally substituted methylene or ethyle...
WO/1996/016030A1	IMINOOXYMETHYLENE ANILIDES, PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING THE SAME AND PESTICIDES CONTAINING THE SAME Iminooxymethylene anilides have the formula (I), in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbo...
WO/1996/016027A1	MATRIX METALLOPROTEASE INHIBITORS Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviate...
WO/1996/016020A1	METHOD OF SYNTHESIZING A 2-SUBSTITUTED NITROGEN-CONTAINING COMPOUND The present invention relates to a method of synthesizing a 2-substituted nitrogen containing compound having formula (I), by reacting a hydroxylamine of formula (II); or a nitrone of formula (III); with a compound of formula (IV); there...
WO/1996/016026A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Compounds of formula (I), wherein Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR13; A is ...
WO/1996/015096A1	SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA-B-D-E-G, ...
WO/1996/015092A1	LIQUID CRYSTAL COMPOUNDS HAVING PERFLUOROETHER TERMINAL PORTIONS Fluorine-containing liquid crystal compounds comprise a fluorocarbon terminal portion having at least one catenary ether oxygen and a hydrocarbon terminal portion, the terminal portions being connected by a central core. The compounds ha...
WO/1996/013509A1	FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS Fluorinated alkene compounds having structure (I) wherein Q is -(C=S)-R1, -(C=W)-R2, or -(P=W)R3R4; wherein W is O or S; and R1 to R4 are as defined in claim 1; are useful for controlling nematodes, insects, and acarids that prey on agri...
WO/1996/011188A1	SULFONYLAMINOCARBONYLTRIAZOLINONES WITH SUBSTITUENTS BOUND BY OXYGEN AND SULPHUR New sulfonylaminocarbonyltriazolinones with substituents bound by oxygen and sulphur have the formula (I), in which n equals 0, 1 or 2; R1 stands for hydrogen or an optionally substituted rest from the group alkyl, alkenyl, alkinyl, cycl...
WO/1996/008483A1	GALLIC ACID DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS Products of formula (ID), in which R1 is hydrogen, carboxy, formyl, alkyl, hydroxyalkyl, alkoxyalkyl, carbamoyl, N-alkyl-carbamoyl, NNdialkylcarbamoyl, alkoxycarbothioate or alkylcarbonyl, V1 is oxygen or -NH-, V2 is -V1H or hydrogen and...
WO/1996/007652A1	SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION CALICHEAMICIN MIMICS Synthetic calicheamicin mimics employ alternative activation triggers and trigger sites and include tethers for conjugation to DNA targeting systems.
WO/1996/007633A1	PHENYLACETIC ACID ALKYL ESTERS The invention pertains to phenylacetic acid alkyl esters of formula I, wherein the index and substituents are as follows: R' is formyl, alkyl carbonyl or alkyl; R'' is alkyl; U is -O-, -S-, -NH- or -NHO-; V is -O-, -S-, or -NH-; X is cya...
WO/1996/007636A1	IMIDIC ACID DERIVATIVES AND THEIR USE AS PESTICIDES The invention pertains to new imidic acid derivatives of formula (I), methods for preparing them and their use as pesticides.
WO/1996/006072A1	OXIME ETHERS AND THEIR USE AS PESTICIDES Compounds of formula (I) are suitable for controlling and preventing infestation by micro-organisms, insects and acarina on plants and their possible isomers and mixtures of isomers, wherein (a) X is CH2F or CHF2, Y is CH and Z is OCH3, ...
WO/1996/004239A1	N-ALKOXY-AMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES New N-alkoxy-amidine derivatives having the formula (I) are disclosed, as well as a process for preparing the same and their use as pesticides. Also disclosed are new intermediate products and a process for preparing the same.
WO/1996/003120A1	INDENE sPLA2 INHIBITORS A class of novel indene-1-functional compounds is disclosed together with the use of such indene compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indene-1-...
WO/1996/002500A1	TECHNETIUM-SULPHONAMIDE COMPLEXES, THEIR USE, PHARMACEUTICAL AGENTS CONTAINING THEM, AND PROCESS FOR PRODUCING THE COMPLEXES AND AGENTS The invention relates to novel chelate formers containing sulphonamide groups and their metallic chelates of general formula (I) in which n, m, p, V1, V2, V3, V4, X1, X2, X3, R1, R2, R3 and R4 have different meanings, pharmaceutical agen...
WO/1995/035284A1	TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS Compounds of general formula (1) are described wherein =W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XRa group where X is -O-, -S(O)m-[where m is zero or an integer of value 1 or 2], or -N(Rb)- where Rb is a hydrogen atom ...
WO/1995/035281A1	TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS Compounds of general formula (1) are described, wherein = W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XRa group where X is -O-, -S(O)m- [where m is zero or an integer of value 1 or 2], or -N(Rb)- [where Rb is a hydrogen a...
WO/1995/034536A1	PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES A group of 2-amino-3-aroyl-benzo['beta']thiophenes are prepared by preparing an 'alpha'-hydroxy thioacetamide by silyl mediated condensation of an aldehyde with an anion of dialkylamino thioformamide, cyclizing the 'alpha'-hydroxy thioam...
WO/1995/034534A1	ENZYME INHIBITORS A compound of formula (I), wherein R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkyl C1-6alkyl group, each optionally substituted by one to three gro...
WO/1995/033710A1	CARBAMOYL CARBOXYLIC ACID HYDRAZIDES AND THEIR USE AGAINST FUNGI Disclosed are carbamoyl carboxylic acid hydrazides (I) and their salts, wherein: R1 is optionally substitued alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl or an optionally substituted non-aromatic carbo- or hetero...
WO/1995/032185A1	N-(3-AMINO-2-HYDROXYBUTYL)SULPHONAMIDE DERIVATIVES AS HIV PROTEASE INHIBITORS HIV protease inhibitors of formula (1), in which Q1 to Q8, E, and Y are as defined in Claim 1, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV viru...
WO/1995/032184A1	SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS Aminimide- and oxazolone-based molecules, and arrays thereof, having at least two structural diversity elements are made via systematic modular production. A combinatorial library of aminimide- and oxazolone-based molecules is made via s...
WO/1995/029899A1	ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS The invention concerns compounds of formula (I) and their salts, W1, W2, R, n, R1, R2, R4, X, Y and Z being defined as in claim 1 and R3 meaning an acyl residue. These compounds are suitable as herbicides and plant-growth regulators. The...

Matches 501 - 550 out of 2,851	< 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >