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WO/2003/087026A1 |
Compounds of the general formula (I) are valuable therapeutics for the treatment of cancer and cancer related diseases.
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WO/2003/084916A2 |
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods o...
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WO/2003/078388A1 |
A process for producing 4,4'−bisphenol sulfone by reacting phenol with sulfuric acid, which comprises conducting the dehydration reaction in a mixed solvent comprising mesitylene and an aliphatic saturated hydrocarbon having a boiling ...
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WO/2003/076406A1 |
Compounds of formula (I) in which each of the phenyl rings represented is optionally substituted one or more times; n represents an integer selected from 0, 1, 2, 3, 4 and 5; W represents -CO-or -SO2-; Z represents H; alkyl; aryl; or ary...
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WO/2003/072062A2 |
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
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WO/2003/070695A1 |
The invention provides processes for producing high-quality dihydroxydiphenyl sulfone isomeric mixtures which little cause color development (color formation) in non-image areas when used in thermal recording paper as the developer; and ...
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WO/2003/068733A1 |
A process for production of dihydroxydiphenyl sulfone isomeric mixtures which comprises reacting phenol with a sulfonating agent through dehydration in an organic solvent to form a dihydroxydiphenyl sulfone isomeric mixture comprising 4,...
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WO/2003/063762A2 |
The present invention discloses a process for the synthesis of reverse hydroxamate matrix metalloproteinase (MMP) inhibitors.
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WO/2003/062194A1 |
A process for producing 2,4'-dihydroxydiphenyl sulfone which comprises: subjecting a mixture which has been obtained by the dehydrating reaction of phenol with sulfuric acid or phenolsulfonic acid and contains 4,4'-dihydroxydiphenyl sulf...
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WO/2003/059335A1 |
The invention relates to the phenyl sulfoxides and phenyl sulfones of formula (I) and to methods for producing the same as well as to their use in the production of drugs for the treatment and/or prophylaxis of diseases, especially Alzhe...
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WO/2003/053920A1 |
The invention relates to crystals of bicalutamide having a specific crystal form, and industrially practicable processes for the production of bicalutamide and crystals thereof which are excellent in environmental friendliness, economica...
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WO/2003/045903A1 |
The present invention relates to hydroxyethylene compounds of formula (I), in which Ra represents a group of formula (a) or (b) where R1 represents −SO2R5, W1 represents CO or SO2, and the other variables are as defined in the claims, ...
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WO/2003/043977A1 |
A process for the preparation of geranyl aryl sulfones represented by the general formula (4): (4) [wherein Ar is optionally substituted aryl&semi and the wavy line represents either of E&sol Z geometrical isomers or a mixture of both], ...
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WO/2003/041668A1 |
The invention relates to a cosmetic composition which is intended, in particular, for bleaching human keratin fibres, particularly hair, which have been dyed with oxidation dyes and/or direct dyes. The inventive composition comprises sul...
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WO/2003/037854A1 |
Disclosed is a method of preparing intermediates required for synthesis of natural carotenoid products using sulfone compounds, which is advantageous in terms of high preparation efficiency due to a relatively simple process. Specificall...
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WO/2003/033461A1 |
The invention relates to intermediate products and a novel method for producing benzocycloheptene C. The inventive method for producing the novel intermediate products of said compound is based on cost-effective starting materials, produ...
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WO/2003/029204A1 |
It is intended to provide a process for producing a mixture of dihydroxydiphenylsulfone isomers containing 2,4’−dihydroxydiphenylsulfone characterized in that 4,4’−dihydroxydiphenylsulfone or a mixture of dihydroxydiphenylsulfone...
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WO/2003/029203A1 |
It is intended to provide a process for producing a mixture of 4,4’− and 2,4’−dihydroxydiphenylsulfone isomers characterized in that trihydroxytriphenyldisulfone or a mixture of dihydroxydiphenylsulfone isomers containing trihydr...
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WO/2003/029202A1 |
4−Isopropoxy−4’−hydroxydiphenyl sulfone can be produced by reacting 4,4’−dihydroxydiphenyl sulfone which has either a content of 4−phenoxy−4’−hydroxydiphenyl sulfone as impurity of 0.1 % or below or a Hasen value of m...
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WO/2003/026597A1 |
The invention relates to a cosmetic composition which is intended, in particular, for bleaching human keratinous fibres that have been dyed with oxidation dyes and/or direct dyes, particularly hair. The inventive composition comprises, i...
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WO2002076934B1 |
A method for removing impurities from 2-nitro-4-methylsulfonylbenzoic acid which comprises at least two of the following steps, in any order, (a) dissolving 2-nitro-4-methylsulfonylbenzoic acid in water at a pH of about 2 to 10, followed...
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WO/2003/022803A1 |
Allyl halide derivatives represented by the general formula (1): (1) [wherein Ar is optionally substituted aryl&semi X is halogeno&semi and the wavy line represents either of E&sol Z geometrical isomers or a mixture of both]&semi and a p...
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WO/2003/022790A2 |
There are described biphenylene compounds of formula (I) wherein R¿1? is a C¿1?-C¿18?alkyl, C¿2?-C¿18?alkenyl, C¿6?-C¿10?aryl or C¿6?-C¿10?aryl or C¿6?-C¿10?heteroaryl radical each unsubstituted or mono- or poly-substituted by...
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WO/2003/022800A1 |
The invention relates to a method for producing 3-bromomethylbenzoic acids of general formula (II) by brominating corresponding 3-methylbenzoic acids. The invention also relates to compounds of general formula (II), wherein R?1¿ represe...
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WO2002040431B1 |
A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided.
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WO/2003/020696A1 |
The invention relates to C2-substituted indane-1-ols and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as per ...
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WO/2003/020697A1 |
The invention relates to C2-disubstituted indane-1-ones and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as p...
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WO/2003/020677A2 |
The invention relates to C2-substituted indane-1-ones and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as per...
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WO/2003/010137A1 |
A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic aci...
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WO/2003/010122A1 |
High yields of ester-substituted diary carbonates such as bis-methyl salicyl carbonate were obtained by the condensation of methyl salicylate with phosgene in the presence of a phase transfer catalyst (PTC) in an interfacial reaction sys...
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WO/2003/006021A1 |
The present invention relates to compounds of formula (I): Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's...
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WO/2002/100339A2 |
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide inter...
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WO/2002/092574A1 |
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...
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WO/2002/088070A1 |
Methods of synthesizing an acylanilide include contacting a compound having the structure of Formula I with a compound having the structure of Formula II under conditions sufficient to provide a compound having the structure of Formula I...
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WO/2002/085843A2 |
The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of formulae (Ia, Ib and Ic) or a mixture thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿, and R?5¿ are defined herein. Compoun...
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WO/2002/083608A2 |
This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides ca...
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WO/2002/079122A2 |
This invention relates to the method of placing a sulfone or sulfonamide group ortho to a phenol in a drug substance in order to increase the metabolic stability and the half-life of the compound, while maintaining the acidity of the phe...
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WO/2002/074762A1 |
A process for producing a sulfone derivative represented by the general formula R-W-S(O)¿2?-X-Y-L?2¿ (IIIa) (wherein R represents an optionally substituted cyclic hydrocarbon group, etc.; W represents a bond or an optionally substitute...
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WO/2002/072519A2 |
A process for carrying out a chemical reaction which is catalysed by one or more metal or hydrogen fluoroalkylsulfonylated compound which process comprises carrying out said reaction in the presence of an ionic liquid or in solvent-free ...
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WO/2002/072260A2 |
A metal bis-triflimde compound having the formula: [M¿x?]?n+¿[(N(SO¿2?CF¿3?)¿2?)¿(nx-yz)?]?(nx-yz)-¿ [L¿y?]?z-¿ where M is a metal selected from the metals in groups 5 to 10, 12 and 14 to 16 and Cu, Au, Ca, Sr, Ba, Ra, Y, La, Ac...
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WO/2002/072518A2 |
The invention relates to a method for producing monocarbonyl compounds or biscarbonyl compounds or hydroxyl compounds by ozonizing unsaturated organic carbon compounds that, per molecule, have one or more olefinic or aromatic double bond...
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WO/2002/072538A1 |
The invention relates to an improved method for producing sulfonyl carboxamide derivatives of formula I wherein the radicals have the cited designations. The compounds can be used, for example, as lipid-lowering agents.
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WO/2002/069909A2 |
This invention encompasses a process for making a compound of Formula A AThese compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammatory agents.
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WO/2002/062752A1 |
A process for producing a cyclic sulfone compound represented by the formula (2) (2) or the formula (4) (4) (wherein the three broken lines indicate that one of the three bonds is a double bond; Ar represents optionally substituted aryl;...
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WO/2002/057221A1 |
A process by which a high-purity 4,4'-dihydroxydiphenyl sulfone monoether can be industrially advantageously obtained. The process, which is for producing a compound represented by the formula (I) (I) (wherein R?1¿ and R?2¿ each indepe...
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WO/2002/048099A1 |
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR?2¿, N(R?2¿)¿2?, NO¿2?, CN, COOR2 ...
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WO/2002/048074A1 |
A method for producing a molecular compound which comprises mixing and kneading a solid host compound and a solid or liquid guest compound by using a kneader and optionally followed by extruding and granulating, wherein the method furthe...
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WO/2002/044140A1 |
The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compou...
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WO/2002/044110A1 |
The present invention relates to an oxidation reaction in the presence of phase-transfer catalyst controlling reaction, which may be represented by general formular [(R1) (R2) (R3) (R4) N]xH¿y?[A], or QmMO3(L). The kind of catalyst itse...
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WO/2002/028823A1 |
The present invention relates to compounds of formula (I), in which R1, R1, A and B have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithromb...
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