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WO/1994/019315A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, ...
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WO/1994/014764A1 |
The present invention comprises a process for the asymmetric synthesis of florfenicol, thiamphenicol or chloramphenicol. In an alternative embodiment, the present invention comprises a process for isomerizing of the S,S-isomer of florfen...
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WO/1994/007850A1 |
Compounds of formula (I) can be produced in a multi-day process from the compounds of formulae (II): R1-SH and (III), in which the constituents R1, R2 and R3 have the meaning given.
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WO/1994/007849A1 |
Compounds of formula (I) in which R1 and R2 have the given significance can be stereoselectively produced by the reaction of acrylic acid or its derivatives or propionic acid with a chiral auxiliary, reaction with a mercaptan, stereosele...
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WO/1994/003837A1 |
The invention relates to a positive-acting radiation-sensitive mixture with: a) a compound which forms an acid under the effect of actinic radiation, b) a compound with at least one C-O-C- or C-O-Si bond which can be split by this acid a...
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WO/1993/020047A1 |
Hydroxamic acid derivatives of formula (I) wherein R?1¿ represents hydrogen or a (C¿1?-C¿6?)alkyl, (C¿1?-C¿6?)alkoxycarbonyl(C¿1?-C¿6?)alkyl, phenyl, substituted phenyl, phenyl(C¿1?-C¿6?)alkyl, heterocyclyl, (C¿1?-C¿6?)alkylca...
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WO/1993/018000A1 |
A process for preparing a compound comprising a monocyclic aromatic ring having at least a first substituent and a substituted sulphonyl group at the position para to said first substituent, the process comprising mixing a reactant compr...
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WO/1993/016036A1 |
Compounds of formula (I), which are defined in more detail in the description, can be prepared by conventional methods and are used for therapeutic purposes in the usual galenical preparations.
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WO/1993/013060A1 |
A compound represented by general formula (I) which is a novel intermediate for synthesizing a 2-(substituted benzoyl)-1,3-cyclohexanedione compound useful as a herbicide; a process for the production thereof; and a process for the produ...
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WO/1993/013055A1 |
Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a...
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WO/1993/012054A1 |
This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.
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WO/1993/011760A1 |
Compounds of the formulae (I, II or III) wherein: R1, R2, R3 and R4 which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or to...
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WO/1993/011102A1 |
The process of the present invention relates to the preparation of precursor trisubstituted benzoic acid intermediates having structural formula (I) wherein R is -COORa wherein Ra is C1-C6 alkyl; C1-C4 alkyl; formyl or C(O)Rb wherein Rb ...
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WO/1993/011103A1 |
Fluorinated hydrocarbon compounds have formula (I): RF-(CH2)n-X-[C3H5(OH)]-(Y)x-RH, in which C3H5(OH) represents structures (Ia) or (Ib): RF is a perfluorinated C4-C20 alkyl radical or a mixture of perfluorinated C4-C20 radicals; RH is a...
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WO/1993/003838A1 |
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention,...
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WO/1993/004039A1 |
Crude diphenylsulfone-4,4'-dicarboxylic acid (44 DDA) is purified by dissolving the crude 44 DDA in boiling acetic anhydride. This results in the formation of acetic acid/44 DDA mono-anhydride, which is separated, recovered and reconvert...
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WO/1992/022560A1 |
A process for synthesizing an optically active starting material, represented by general formula (I), for various medicines with a high optical purity in a good yield, wherein R1 represents hydrogen or hydroxyl-protecting group: * repres...
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WO/1992/015559A1 |
Method for preparing 3'-aminopropyl-2-sulphatoethylsulphone in good yields, characterized in that allylamine is reacted in a one-pot process with mercaptoethanol in aqueous sulphuric acid at temperatures of approximately 25 �C up to th...
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WO/1992/014698A1 |
Described herein is a purification process to make high isomeric purity, essentially colorless 4,4'-dihydroxydiphenyl sulfone from an impure isomeric mixture comprising 4,4'-dihydroxydiphenyl sulfone, 2,4'-dihydroxydiphenyl sulfone, and ...
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WO/1992/014699A1 |
A process is described to make a dihydroxydiphenol sulfone product with a 4,4'-dihydroxydiphenol sulfone purity in excess of 90 wt. % by reaction of phenol and concentrated sulfuric acid in a solvent mixture containing a lower-boiling an...
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WO/1992/014700A1 |
A process allows 4-alkyl(C�1?-C�4?)-sulfonyl-1-alkyl-2-chlorobenzenes to be produced with high yields and selectivity. Chlorides of p-alkylbenzene sulfonic acid are selectively chlorinated with gaseous chlorine in the presence of a c...
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WO/1992/007824A1 |
A process for preparing a compound of formula (IV) comprising: a) contacting an oxazoline compound of formula (I) wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and a...
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WO/1992/007809A1 |
Process for the production of diaryls of formula (1): R?1¿¿m? - Ar - Ar - R?1¿¿m? in which: Ar is a phenylene or naphthylene group; R¿1? is a hydrogen, fluorine or chlorine atom or an unbranched or branched alkyl (C¿1?-C¿6?)-alkyl...
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WO/1992/005151A1 |
This invention relates to salts of formula (I) where, A is 1 and X is 1 or 2; R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 alkylthio, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alko...
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WO/1992/004020A1 |
The present invention relates to a method of inhibiting superoxide generation which comprises administering to a mammal in need of such treatment an amount of a compound of formula (I), wherein R1 and R2 are the same or different and ind...
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WO/1992/002493A1 |
A process of preparing 4,4'-Bisphenol S wherein sulfuric acid is reacted with an excess of phenol while removing water; the product purity is improved with respect to the 2,4'-BPS isomer by adding toluene to the initial product mixture t...
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WO/1991/017978A2 |
Mono-acylated hydrazines are prepared in high yield by reaction of a hydrazine salt with an azole derivative of acyl halide in the presence of a strong base. Useful hydrazine salts include those of the formula RNHNH2.HX, where R is alkyl...
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WO/1991/013866A1 |
In a method for preparing 3'-aminopropyl-2-sulphatoethylsulphone in a one-pot process, allyl amine is reacted with mercaptoethanol in dilute sulphuric acid at temperatures of approximately 50 �C up to the boiling point in the presence ...
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WO/1991/011433A1 |
A process for producing a diphenyl sulfone compound of general formula (I) by the reaction of a 4,4'-dihydroxydiphenyl sulfone with a compound R-X (wherein R represents C1 and C8 alkyl, C3 to C8 cycloalkyl, C2 to C8 alkenyl, or arylalkyl...
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WO/1991/009839A1 |
A process for producing 4,4'-dihydroxydiphenyl sulfone by heating a mixture of 4,4'-dihydroxydiphenyl sulfone with 2,4'-dihydroxydiphenyl sulfone in the presence of an acid catalyst to thereby isomerize the 2,4'-isomer into the 4,4'-isom...
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WO/1991/007385A1 |
Compounds of formula (I), in which Ar is aryl and R?1¿ and R?2¿ are alkyl, are obtained by a process in which a compound of formula (II), where Z is a disubstituted amino group, is reacted (a) with an alcohol, R?2??OH, preferably under...
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WO/1991/007384A1 |
Process for the production of alkyl-(3-chlorophenyl) sulphones of formula (I) in which R¿1? and R¿2? are straight-chained or branched alkyl (C¿1?-C¿4?) groups which may be the same or different, by reacting alkyl phenyl sulphones of ...
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WO/1991/006534A1 |
The invention relates to novel mono and/or bi-ethers and mono and/or bi-esters of thiodiglycol sulphates and/or sulphones of the general formula (I) in which X¿1? and/or X¿2? are especially beta-hydroxyl-substituted alkyl residues and/...
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WO/1991/004245A1 |
A process for preparing 4,4'-dihydroxydiphenyl sulfone which comprises conducting a dehydration reaction of phenol with a sulfonating agent to prepare 4,4'-dihydroxydiphenyl sulfone, characterized by allowing the reaction to proceed whil...
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WO/1991/003462A1 |
The invention concerns a method of preparing high-purity 4,4'-dihydroxydiphenylsulphone in high yields by reacting phenol with a sulphonating agent in a chorinated aromatic compound. The phenol is reacted with the sulphonating agent in o...
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WO/1991/003473A1 |
Intermediates of structural formula (III) or (Va) having an asymmetric center as indicated by an asterisk (*) and being substantially free of its opposite enantiomeric form, wherein Z represents O or NOP1; P1 is (a), (b), (c), H, alkyl, ...
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WO/1991/001300A1 |
Compounds of formula (I) or of formula (II), wherein Ar is a substituted or unsubstituted aryl group, and T is selected from the class consisting of carboxy, carboxy ester groups, or a substituted or unsubstituted aryl group, Z is a coup...
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WO/1990/015795A1 |
The invention relates to a process for the preparation of guanidine-derivatives of general formula (I), wherein R means a C1-4 alkyl group, M means a hydrogenatom, sodium-, potassium-, or calcium ion, A means an -S-, -SO-, or -SO2-group;...
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WO/1990/015793A1 |
A salt of 4-[3-[ethyl-[3-(propylsulfinyl)propyl]amino]-2-hydroxypropox
y]-benzonitrile having formula (I) with polystyrenesulphonic acid, which is useful for the treatment of cardiac arrhythmia, process for the preparation of said salt a...
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WO/1990/015794A1 |
4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydrox
ypropoxy]-benzonitrile, 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydrox
ypropoxy]-benzonitrile, 4-[3-[ethyl[3-((R*)-propylsulfinyle)propyl]amino]-2(S)-hydro
xyprop...
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WO/1990/013537A1 |
A process for the production of alkane sulphonyl benzoic acids in which alkane sulphonyl alkyl benzoles of the formula (I) in which R?1¿ and R?2¿ are the same or different and are alkyl with 1 to 4 C atoms, but R?2¿ is not t-butyl, an...
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WO/1990/012000A1 |
The subject matter of the invention is a process of synthesis of sulphonylmethanes and their derivatives corresponding to the formula M[(RSO2)2CH]m (I), in which M represents H, an alkaline or alkaline-earth metal or (a), R' and R are mo...
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WO/1990/010618A1 |
This invention provides a novel method for the preparation of optically active arylalkylsulfone derivatives, having a chiral center in the alkyl moiety in either the (R)- or the (S)-configuration. These optically active sulfones find use...
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WO/1990/006295A1 |
A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing ...
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WO/1990/006301A1 |
Compounds having structural formula (I), wherein R is chloro, bromo or nitro, are used in the preparation of 2-(chloro, bromo or nitro)-4-(alkyl-sulfonyl) benzoic acid compounds having structural formula (II), wherein R is chloro, bromo ...
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WO/1990/006302A1 |
A process for the preparation of a 2-halo-4-(alkylsulfonyl)benzoic acid of structural formula (I), wherein halo is chloro or bromo and R is C1-C4 alkyl by the oxidation of 2-halo-4-(alkylsulfonyl)toluene under acid conditions.
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WO/1989/005806A1 |
Novel compounds of formula (I), wherein A is a group (a), (b), (c), (d), (e), (f) or (g), useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparati...
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WO/1989/005795A1 |
Novel compounds of formula (I), wherein A is a group (a), (b), (c), (d), (e), (f), (g), useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation...
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WO/1989/005794A1 |
A compound of formula (I) and when appropriate in the form of a racemic mixture or in the form of a stereoisomeric component and the pharmaceutically acceptable salts thereof, in which formula: n is an integer 0, 1 or 2, Y is [CH2]m, CHO...
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WO/1989/005290A1 |
Aminoaryl-beta-sulphatoethylsulphone compounds, for example 4-(beta-sulphatoethylsulphonyl)-aniline, can be made simply and quickly from their corresponding beta-hydroxyethylsulphone compounds by sulphation. A solution, suspension or pas...
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