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WO/2017/137147A1 |
The present invention relates to novel crystalline modifications of N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications ...
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WO/2017/130798A1 |
Disclosed is a polyarylene sulfide resin having a main chain including a structural unit represented by general formula (1.1). No absorption peak derived from the S=O stretching vibration of a sulfonyl group is observed in the infrared a...
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WO/2017/098900A1 |
The present invention is a method for purifying dimethyl sulfoxide, comprising distilling a dimethyl sulfoxide-containing liquid in an inert gas atmosphere in the presence of sodium carbonate to distil out dimethyl sulfoxide, wherein the...
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WO/2017/093172A1 |
Disclosed is a method for producing 2-alkyl-4-trifluoromethyl-3-alkyl sulfonyl benzoic acids of formula (I). In said formula, the substituents represent groups such as alkyl and substituted phenyl.
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WO/2017/095119A1 |
A polythiol compound of an embodiment, which is obtained by reacting a sulfide compound having two or more triple bonds with an alcohol compound having a mercapto group to prepare a tetrafunctional or higher functional polyol compound co...
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WO/2017/073468A1 |
A compound represented by formula (3) (wherein R1 represents a C1-C6 alkyl group which may have at least one halogen atom; R2 represents a C1-C6 alkyl group; and m represents an integer of 0 to 3) can be produced by reacting a C1-C6 alka...
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WO/2017/072038A1 |
A method for synthesizing 2-alkyl-4-trifluoromethyl-3-alkylsulfonyl-benzoic acids of formula (I) is described. In said formula (I), the substituents represent groups such as alkyl and substituted phenyl (formulae (II)-(V), (V)-(I)).
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WO/2017/064723A1 |
The present invention relates to and an improved process for the preparation of Armodafinil with high purity and high yield. The present invention also related to preparation of Armodafinil polymorphic Form-1 with a particle size of abov...
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WO/2017/064910A1 |
The present invention is a method for preventing the decomposition of dimethyl sulfoxide, said method comprising adding sodium carbonate in an amount of 0.0005 to 2 g relative to 100 g of dimethyl sulfoxide contained in a dimethyl sulfox...
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WO/2017/057460A1 |
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...
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WO/2017/046319A1 |
The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et
hyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or...
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WO/2017/014214A1 |
A compound represented by formula (4) can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3) and then subjecting the resultant mixture to a reduction reaction, w...
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WO/2016/202806A1 |
The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.
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WO/2016/197900A1 |
A process for the preparation of mesotrione enolate is provided, the process comprising providing a solution of mesotrione in an organic solvent and contacting the solution with a moderate base in the presence of water at a pH of from 6 ...
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WO/2016/199031A1 |
Present application relates to the process for the preparation of 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (II), its resolution and its use in preparation of Apremilast of formula (I), process for the pre...
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WO/2016/201039A1 |
A process for preparing diaryl sulfones, such as 4,4'-dichlorodiphenylsulfone is disclosed. The process comprises contacting an aryl compound with sulfur trioxide to provide a benzene sulfonic acid. The benzene sulfonic acid is coupled t...
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WO/2016/192694A1 |
The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-...
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WO/2016/194929A1 |
Compounds shown by formula (3): (in the formula, R1 represents a C1-C6 perfluoroalkyl group, R2 represents a C1-C6 alkyl group, and m represents any integer of 0-3) or salts thereof which are useful as production intermediates of pharmac...
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WO/2016/196664A1 |
The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA acitivity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.
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WO/2016/189486A1 |
The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of ...
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WO/2016/175128A1 |
The present invention relates to a process for producing an allyl-substituted bisphenol compound, the process including a step in which a diallyl-etherified bisphenol compound represented by general formula (I) is caused to undergo therm...
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WO/2016/173020A1 |
A conjugated compound containing a diphenyl sulfone phenyl structure, a method for preparing same, and use for fabricating a light emitting layer or an electronic transmission layer of an organic electroluminescent diode. The compound ha...
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WO/2016/174685A1 |
A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylami
ne using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsul...
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WO/2016/161996A1 |
The present invention provides a method of chiral resolution of racemic amines of the benzyl type by means of salts formed with tartaric acid of formula (3) and intermediate of formula (2), and their use in the synthesis of Apremilast of...
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WO/2016/086710A1 |
Disclosed is a carboxylic acid preparation method. The method is characterized in that: a compound (II) reacts in the presence of hydrogen peroxide and a base to produce a target product (I) represented by the following equation: R1 is a...
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WO/2016/076160A1 |
[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method charac...
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WO/2016/039691A1 |
Compounds of formula (I): wherein R and A- are defined herein as a catalyst for making chiral heterocyclic sulfoxides and a method of producing enantioenriched sulfoxide in the presence of the said compounds.
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WO/2015/198850A1 |
Provided is a method for producing a compound represented by formula (2-b), which is useful as an intermediate for producing agricultural chemicals. The method includes a step for obtaining a compound represented by formula (2-a) by oxid...
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WO/2015/196086A1 |
The present invention is directed to novel inhibitors of system Xc _, also known as the cystine/glutamate antiporter. The present invention is further directed to methods of treating and detecting cancer that overexpresses system Xc _ wh...
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WO/2015/181249A1 |
The present invention relates to processes for preparing β-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of sulfone group containing isoindoline-based compounds, in particular apremilast.
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WO/2015/157927A1 |
Disclosed is a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug Administration by a series of combinations of cyclization, selective reduction, fluorinated open ring, depro...
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WO/2015/087352A1 |
The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.
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WO/2015/062103A1 |
Disclosed are a refining method for 2-nitro-4-methylsulfonyl benzoic acid and an intermediate thereof. The method comprises the following steps of: synthesizing an intermediate organic ammonium salt (III) in an organic solvent using a cr...
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WO/2015/051141A1 |
Methods for preparing fluorinated sulfides and fluorinated sulfones are described. To prepare a fluorinated sulfides, a sulfur-containing reactant represented by the formula: R1SM or M2S, wherein R1 is a C1 to C10 alkyl or fluoroalkyl, S...
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WO/2015/048328A1 |
The present invention is directed to 3, 4-bis-benzylsulfonylbutanenitrile, or a pharmaceutically acceptable salt, an enantiomer, or enantiomers thereof. The present invention is also directed to a pharmaceutical composition comprising a ...
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WO/2015/032328A1 |
The present invention relates to an indane derivative, a preparation method therefor, and a pharmaceutical application thereof. Specifically, the present invention relates to a compound shown in formula (I), or a stereoisomer thereof, an...
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WO/2015/010655A1 |
Triadic fused cyclic carboxylic acids derivatives, preparation method therefor and pharmaceutical use thereof, particularly relating to compounds represented by general formula (I), stereoisomers, hydrates, solvates, metabolites, eutecti...
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WO/2014/191475A1 |
The present invention relates to a process for oxidizing a sulfoxide to the respective sulfone, said process comprising reacting the sulfoxide with hydrogen peroxide in the presence of a catalyst, obtaining a mixture (M) comprising the s...
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WO/2014/178309A1 |
The present invention provides a method for purifying dimethyl sulfoxide economically and at good yield so as to satisfy the specifications of the United States Pharmacopoeia and reduce odor. The method is characterized in that a solutio...
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WO/2014/175187A1 |
Provided is a method for preparing, in an economical manner and with favorable yield, a dimethylsulfoxide having a reduction in malodor and satisfying the stipulations of the United States Pharmacopoeia. The present invention is characte...
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WO/2014/170709A1 |
A method for controlled production of mono and diether derivatives of 4,4'-dihydroxydiphenyl sulfone (SDP) namely 4-substituted-4'-hydroxydiphenyl sulfones and 4,4'-disubstituted diphenyl sulfones in high yields by reacting alkyl halide ...
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WO/2014/168297A1 |
A sulfone-based compound of the present invention is characterized by being represented by chemical formula 1 in the specification. The sulfone-based compound has a hydrocarbon core and an ether sulfone unit, wherein the properties of th...
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WO/2014/146275A1 |
The present invention relates to a method for synthesizing a thiadiazole sulfoxide compound. Steps thereof comprise: thiadiazole thioether reacting in an organic solvent or mixed liquor of an organic solvent and water, by using a specifi...
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WO/2014/095103A1 |
The invention relates to an ester having at least one sulphonic group on the acid chain, a method for the production thereof and the use of the ester as a plasticizer for polymers.
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WO/2014/087017A1 |
The invention relates to a process for the preparation of a levulinic acid ester from a composition comprising levulinic acid and optionally a compound having a boiling temperature of less than 245°C, said process comprising: - subjecti...
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WO/2014/082581A1 |
Disclosed is an α-(3, 5-dimethoxy benzylidene)-α'-hydrocarbyl methylene cyclic ketone, having a structure as represented by (I) or (II), wherein R is an aryl or alkyl; a preparation method is: mixing cyclic ketone and morpholine, and a...
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WO/2014/067235A1 |
Provided is a dimethylsulfoxide preparation method, the method comprising the following steps: 1) bringing hydrogen sulfide in contact with methanol to obtain a mixture containing dimethyl sulfide, and separating the dimethyl sulfide fro...
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WO/2014/050814A1 |
[Problem] To provide a method for producing a compound having a bis(trifluoroalkanesulfonyl)methyl group, which is a compound having a high acidity degree and hydrophobicity and useful as a raw material compound for a resin, and a salt t...
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WO/2014/038763A1 |
The sulfone-based compound of the present invention is characterized by having an activating group for radical polymerization, and an ether-sulfone unit. Preferably, the activating group for radical polymerization can be a compound compr...
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WO/2014/022879A1 |
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment...
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