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JP2017019859A |
To provide acetaminophen conjugates, and to provide compositions and methods of use thereof.Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have ...
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JP6039575B2 |
Described herein is a method comprising:(a) reacting a terminal alkene compound with a halofluorosulfonylfluoride to produce a halohydrofluorosulfonylfluoride;(b) dehalohydrogenating the halohydrofluorosulfonylfluoride to produce an alke...
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JP6029670B2 |
Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to ace...
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JP5997264B2 |
Described herein are allyl ether-terminated fluoroalkylsulfinic acids and salts thereof and methods of making.
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JP5976733B2 |
In its many embodiments, the present invention provides provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds ster...
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JP5902712B2 |
There is provided a process for preparing a perfluorovinyl ether sulfinate, comprising: a) providing a perfluorovinyl ether sulfonyl halide; and (b) reducing the perfluorovinyl ether sulfonyl halide with a reducing agent in an organic pr...
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JP5893724B2 |
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy ...
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JP5869311B2 |
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JP5844819B2 |
There is provided a method for preparing oligomers and co-oligomers of highly fluorinated sulfinic acids and salts thereof.
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JP5837610B2 |
Described herein is a composition comprising a fluorinated polysulfinic acid or a salt thereof having the following formula (I): wherein X1, X2, and X3 are independently selected from H, F, CI, Br, I, CF3, and CH3 and wherein at least on...
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JP2015529666A |
The present invention relates to its use as an inhibitor of spiroring acylguanidine and β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing it, and disorders characterized by neurodegenerative disorders, cognitiv...
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JP5778936B2 |
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JP5708663B2 |
A radiation-sensitive resin composition includes a compound represented by a formula (1), and a polymer that includes a structural unit having an acid-labile group. R1 and R4 each independently represent a hydrogen atom, or the like. R2 ...
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JP5655633B2 |
In a method for obtaining an alkali metal perfluoroalkanesulfinate by reacting a perfluoroalkanesulfine halide with a sulfur-containing reducing agent in the presence of water, a reaction liquid containing the alkali metal sulfinate obta...
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JP5604255B2 |
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JP5591494B2 |
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JP5549289B2 |
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JP5549288B2 |
When sulfinating a carboxylic acid bromofluoroalkyl ester by using a sulfinating agent, an organic base is used, thereby obtaining a fluoroalkanesulfinic acid ammonium salt. This is oxidized to obtain a fluoroalkanesulfonic acid ammonium...
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JP5506914B2 |
A method for preparing fluoroalkanesulphinic acid esters is described. The preparation of esters of trifluoromethanesulphinic acid, commonly referred to as "triflinic acid," is also described. A method for preparing a fluoroalkanesulphin...
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JP5501243B2 |
The present invention relates to a method for preparing a salt of trifluoromethanesulphinic acid termed "triflinic acid". More specifically, the invention relates to a method for preparing a highly pure triflinic acid salt. The method of...
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JP5486603B2 |
The invention relates to a process for purifying trifluoromethanesulfinic acid by azeotropic distillation with an aromatic solvent, to processes for preparing purified trifluoromethanesulfinic acid and to the use of the purified trifluor...
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JP5471121B2 |
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JP5437069B2 |
The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in Claim 1, and to liquid-crystalline media comprising at least one compound of...
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JP5430579B2 |
The present invention relates to a method for preparing a highly pure trifluoromethanesulphinic acid. The method of the invention for preparing a highly pure trifluoromethanesulphinic acid, starting from an aqueous mixture comprising a t...
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JP5370990B2 |
To provide a sulfenamide compound extremely useful as an intermediate for a polymer-based herbicide, sterilizer or the like, and having multiple bonds in the molecule, and to provide a method for efficiently producing the compound. The s...
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JP5347371B2 |
By using an organic base when a carboxylic acid bromodifluoroethyl ester is sulfinated by using a sulfinating agent, there is obtained 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfinic acid ammonium salt. By oxidizing the 2-(alkylcarbonylo...
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JP2013531628A |
Provided are dibenzocyclooctene lignan derivatives having the following structural formula and their uses in the treatment of viral hepatitis. Said dibenzocyclooctene lignan derivatives have bioactivity of anti-hepatitis B virus (anti-HB...
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JP5236629B2 |
Oxysulfide and fluorinated organic compounds, for example, perfluoroalkanesulfinic and sulfonic acids, and preferably trifluoromethanesulfinic and trifluoromethanesulfonic acids in salt form, are prepared by reacting, in the presence of ...
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JP5234371B2 |
Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compoun...
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JP2013507325A |
Compounds are provided that comprise dinitroso-derivatives of dihydrolipoic acid. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating various diseases and disorders, including angina, hype...
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JP5123667B2 |
The invention relates to compounds of the formula I in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and the pharmaceutically acceptable salts thereof. Because of their properties as inhibitors of chemo...
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JP2013501733A |
The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in ...
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JP2012176902A |
To provide a highly selective and efficient method for producing an optically active 3,3,3-trifluoroalanine and an optical active 2-methylpropyl-2-sulfinic acid (1-cyano-2,2,2-trifluoroethyl)amide as an intermediate of the above compound...
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JP2012513450A |
An oligonucleotide which comprises at least one internucleotide linkage comprising a P-S-R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH2, X...
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JP4895230B2 |
Disclosed is a salt of trans-4-sulfinylamino-1-cyclohexanecarboxylic acid. Also disclosed is a method for producing a salt of trans-4-sulfinylamino-1-cyclohexanecarboxylic acid.
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JP4853752B2 |
The present invention provides a process for producing 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of formula (II) with a halogenating agent in the presence of Pd catalyst: (wherein A is -OH, ...
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JP2011256130A |
To provide a new method for producing a carbamate.The method for producing a compound represented by formula (II) (wherein, R1 and R2 are each a substituted or non-substituted alkyl or the like) includes reacting one molar equivalent of ...
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JP2011162464A |
To provide a method for producing a sulfinate salt compound useful as an intermediate for medicines and agrochemicals.The sulfinate salt compound represented by formula (A) (wherein substituent R1 and R2 are each a hydrogen atom, 1-8C ch...
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JP2011520785A |
There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases ...
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JP4723499B2 |
Compositions are provided that include an electron donor and a sensitizing compound. More specifically, the electron donor is an arylsulfinate salt. Methods of polymerization are also provided that can be used to prepare polymeric materi...
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JP4607882B2 |
Compositions are provided that can be used as an initiator system for free radical polymerization reactions. More specifically, the initiator systems include an electron acceptor and an electron donor. The electron donors are arylsulfina...
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JP2010265274A |
To provide a new method for producing N-debenzoylpaclitaxel which is a precursor of paclitaxel having antitumor activity. The method includes condensation of a carboxylic acid expressed by formula (II) (in the formula, R1 is aryl or hete...
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JP2010248209A |
To provide a nonsteroidal antiinflammatory compound which does not have a side effect which accompanies a compound of prior art, and to provide a novel and improved method for treating inflammatory disease states and disorders, and for t...
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JP4546477B2 |
Compositions are provided that include a photoinitiator system for free radical polymerization reactions. More specifically, the photoinitiator includes an arylsulfinate ion and a triarylsulfonium ion. Polymerization methods are also pro...
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JP4545942B2 |
alpha-Sulfenimino acid derivatives of formula Iincluding the optical isomers thereof and mixtures of such isomers, whereinA is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally substituted,B is a direct bond or optionally sub...
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JP4502280B2 |
Disclosed is a process for the preparation of Compound (III), salt or solvate thereof by reacting Compound (I), salt or solvate thereof with Compound (II) in a toluene solvent in the presence of an additive such as water or an alcohol. A...
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JP4494044B2 |
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JP2010517985A |
A method for the preparation of fluorinated sulfanylamides and sulfinamidines, involves the reaction of dialkylaminosulfur trifluoride with a perfluoroalkyl-trialkyl-silane in presence of a tert. amine to give a perfluoroalkyl-difluorosu...
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JP2010500976A |
Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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JP4394451B2 |
This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SK Ca and/or IK Ca channels.
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