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WO/1997/018190A1 |
N-Protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates of formula ...
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WO/1997/017336A1 |
The present invention relates to processes for the preparation of 3-(1-piperazinyl)-1,2-benzisothiazole or its pharmaceutically acceptable salt and to novel intermediates used in the process. 3-(1-piperazinyl)-1,2-benzisothiazole is a ke...
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WO/1997/008145A1 |
The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A is (a) or (b) or (c) or (d) pharmaceutical compositions thereof and methods of using such compounds...
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WO/1997/008210A1 |
Ecologic antifouling material to apply to internal surfaces of the polymerization reactors of the naphthenic structure type having a radical (OH), in position 1 and in one or more of positions 2, 3, 4 according to structure (I).
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WO/1996/040693A1 |
The present invention is directed to novel vinyl sulfenic acid derivatives, and to a new process for the synthesis of novel vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particula...
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WO/1996/037459A1 |
The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride, comprising the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and...
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WO/1996/030329A1 |
The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
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WO/1996/015106A1 |
The present invention provides a compound of formula (I), wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkoxyalkoxy, C...
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WO/1995/030651A1 |
'alpha'-amino acid amides of formula (I), in which n is the number zero or one; R1 is C1-C12alkyl, which is unsubstituted or can be substituted by C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbon...
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WO/1995/018107A1 |
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof, wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1...
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WO/1995/000474A1 |
Methods of making unnatural amino acids which can be incorporated into peptides which either inhibit or promote the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads which method comprise...
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WO/1994/004492A1 |
Hydroxyethylamino sulfonamide compounds of formulae (I, II) wherein R, R\', R1, R1\', R1\'\', R2, R3, R4, R6, x, t, Y, P1 and P2 are as defined in Claims 1 and 171, are effective as retroviral protease inhibitors, and in particular as in...
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WO/1993/019754A1 |
Fused aryl derivatives are described as lusitropic agents for use in the treatment of cardiovascular disease where there is a component of diastolic failure.
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WO/1993/019046A1 |
A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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WO/1993/015046A1 |
Carbamate having the formula (I), its plant-compatible acid addition and basic addition products, and fungicides containing the same are disclosed.
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WO/1992/020682A1 |
Substituted anilides of formula (I), wherein Q is one of (Q-1), (Q-2) and (Q-3), and R?1� to R?5�, Y, Z and Z?1� are as defined in the text, arthropodicidal compositions containing such compounds; and a method for controlling arthr...
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WO/1992/018003A1 |
The present invention provides inhibitors of kynureninase having formula (I), where X is CHOH, S, SO�2?, SO, SONH, PO�2?H or PONH�2?, R�A? and R�B?, independently of one another, are H, a halogen CF�3? or a small alkyl group ...
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WO/1992/017445A2 |
S-nitrosothiols exert a potent relaxant effect, mediated by guanylate cyclase, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols m...
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WO/1992/017170A1 |
Form of taurine administration giving rise to a novel therapeutic use. The pharmaceutical composition contains taurine or hypotaurine in combination with means for its administration by inhalation, especially in aerosol form, where the t...
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WO/1992/015601A2 |
Heterocyclic antitumor compounds are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, CNS cancer and melanoma. Pharmaceutical com...
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WO/1992/014700A1 |
A process allows 4-alkyl(C�1?-C�4?)-sulfonyl-1-alkyl-2-chlorobenzenes to be produced with high yields and selectivity. Chlorides of p-alkylbenzene sulfonic acid are selectively chlorinated with gaseous chlorine in the presence of a c...
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WO/1992/012709A1 |
A composition for use in inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a macrocyclic compound composed of aryl ring subunits connected one to another by ring...
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WO/1992/008698A1 |
Compounds represented by formula (I) wherein A represents R, R?13¿ and radicals represented by formula (II), B represents R?5¿ and radicals represented by formula (III) (values for the variables given herein) are effective as retrovira...
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WO/1992/008700A1 |
Compounds represented by formula (I) or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein A represents radicals represented by formulae (A1, A2, A3) (values for the variables given herein), are effective as retroviral...
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WO/1991/017987A1 |
Fused aryl phenol/pyridinol derivatives are disclosed as medicaments.
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WO/1991/016301A1 |
The present application discloses pesticidally active compounds of the formula (I): QQ1CR1 = CR2CR3 = CR4C(=X1)NR5R6, or a salt thereof, wherein Q is a monocyclic aromatic ring, or fused bicyclic ring system of which at least one ring is...
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WO/1991/006543A1 |
Peptides which include unnatural amino acids and which either inhibit or promote the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount of such pepti...
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WO/1990/006301A1 |
Compounds having structural formula (I), wherein R is chloro, bromo or nitro, are used in the preparation of 2-(chloro, bromo or nitro)-4-(alkyl-sulfonyl) benzoic acid compounds having structural formula (II), wherein R is chloro, bromo ...
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WO/1989/006648A1 |
Cysteamine derivatives represented by general formula (I) (wherein R1 represents a straight-chain or branched alkyl group containing 1 to 6 carbon atoms, R2 represents a hydrogen atom or an n-propyl group, and X represents a group contai...
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WO/1989/001931A1 |
The present invention relates to the chemical modification of generally inert compounds containing at least one perfluorocarbon moiety of the general formula R1R2R3C-F wherein each of R1, R2 and R3 may represent F or a substituted carbon...
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WO/1988/009782A1 |
A process for preparing an aromatic propargyl ether, preferably bispropargyl ether, from hydroxyaromatic compounds comprising vigorously stirring a propargyl halide, preferably propargyl chloride, with a hydroxyaromatic compound, such as...
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WO/1988/009326A1 |
There are described compounds of formula (I), in which one of R30 and R40 represents a group (Ra), and the other of R30 and R40 represents hydrogen or halogen, R50 and R60, which may be the same or different, each independently represent...
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WO/1988/007513A1 |
The invention relates to a process for the vapor phase bromination of aromatic compounds in the presence of oxygen and a catalyst containing an oxidizing metal and an inert support.
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WO/1988/007512A1 |
The invention relates to a process for isomerizing and transiodinating iodoaromatic compounds over a non-acid catalyst.
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WO/1988/007516A1 |
Ethine derivatives of the formula R1-(A1-Z1)m-A3-C=C-A4-(Z2-A2)n-R2, in which R2 = -OCF3'-OC2F4H or -OC2F5 are suitable as components of liquid crystal phases.
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WO/1988/007510A1 |
The invention relates to a process for isomerizing liquid iodoaromatic compounds over an acid catalyst.
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WO/1988/007509A1 |
A process for iodinating an aromatic compound in which a source of iodine is reacted with the aromatic compound in the presence of oxygen over a non-acid catalyst wherein the aromatic compound in the presence of oxygen over a non-acid ca...
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WO/1988/007523A1 |
Compositions containing the structural constituents -A3-C=C-A4-in which A3 and A4 each independently represent; a) a 1,4-phenylene residue, in which one or more non-adjacent CH groups may be replaced by N; b) a 4,4-biphenylene residue, i...
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WO/1988/007031A2 |
A process for producing a sulfurized olefin product substantially free of ash containing waste is disclosed. The process involves dehydrohalogenation of an olefin/sulfur halide complex by contacting the complex with a protic solvent in t...
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WO/1988/005050A1 |
A renin inhibiting compound of formula (I), wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl-m...
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WO/1988/003756A1 |
Aminoalkylated hydroxy compounds having formula (I), wherein A represents (II) or (III), wherein (R1)n represents up to four substituents which are the same or different and selected from straight or branched chain, substituted or unsubs...
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WO/1988/001996A1 |
A method is provided for making reaction products of phosgene and dihydric phenol under interfacial reaction conditions. The dihydric phenol such as BPA is introduced into the reactor in the form of a stable suspension which reduces phos...
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WO/1988/001615A1 |
Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R-COO - represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integer from 1 to 3, and R1 and R2 are the same or different and are s...
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WO/1988/001617A1 |
An improvement in processes for preparing diaryl sulfones comprising adding a limited amount of water to the reaction product mixture of such processes to form a heavier aqueous phase containing unreacted monosubstituted benzene sulfonic...
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WO/1988/001264A1 |
2,3-Diaminoacrylonitrile derivative or salts thereof, having formula (I), (wherein R represents an alkyl group which may be substituted by (unsubstituted or substituted phenyl groups, halogen atoms, C1-6 alkoxycarbonyl groups, carboxy gr...
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WO/1988/000940A2 |
Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases.
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WO/1988/000178A1 |
Aryl-diethers which are produced by reacting a halogenated xylene compound, preferably 4-chloro-ortho-xylene, and an alkali metal salt of a bisphenol compound, preferably bisphenol-A. These aryl-diethers serve as precursors in a process ...
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WO/1988/000181A1 |
Antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from mar...
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WO/1987/007265A1 |
Process for the preparation of beta-ketoesters or beta-sulfonylesters wherein silylketene acetals, including ''living'' (meth)acrylic polymers prepared by Group Transfer Polymerization (GTP), are reacted with an acyl compound, such as di...
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WO/1987/006576A1 |
Antidepressant agents having formula (I), wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings h...
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