Title:
THERAPEUTIC AGENT FOR ISCHEMIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/008555
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent for ischemic diseases, the therapeutic agent comprising an apoptosis inhibitor of macrophage (AIM), an AIM fragment having a biological activity of the AIM, or a nucleic acid encoding the AIM or the AIM fragment.
Inventors:
MIYAZAKI TORU (JP)
Application Number:
PCT/JP2022/029282
Publication Date:
February 02, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
MIYAZAKI TORU (JP)
International Classes:
A61K38/17; A61K48/00; A61P1/00; A61P9/10; A61P11/00; A61P29/00; C07K14/47; C12N15/12
Domestic Patent References:
| WO2015119253A1 | 2015-08-13 | |||
| WO2011145723A1 | 2011-11-24 | |||
| WO2005033321A2 | 2005-04-14 | |||
| WO2012057363A1 | 2012-05-03 |
Foreign References:
| JP2017220733A | 2017-12-14 | |||
| JP2021125789A | 2021-08-30 |
Other References:
WANG SHUO, CAI SONGJIE, ZHANG WEITAO, LIU XIGAO, LI YAN, ZHANG CHAO, ZENG YIGANG, XU MING, RONG RUIMING, YANG TIANSHU, SHI BENKANG: "High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 18, no. 1, 1 December 2020 (2020-12-01), XP093029710, DOI: 10.1186/s12967-020-02334-8
ARAI SATOKO; MIYAZAKI TORU: "A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM)", SEMINARS IN IMMUNOPATHOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 40, no. 6, 11 October 2018 (2018-10-11), Berlin/Heidelberg, pages 567 - 575, XP036626557, ISSN: 1863-2297, DOI: 10.1007/s00281-018-0717-6
YAMAGUCHI ATSUSHI, JITSUISHI TATSUYA, HOZUMI TAKASHI, IWANAMI JUN, KITAJO KEIKO, YAMAGUCHI HIROO, MORI YASUTAKE, MOGI MASAKI, SAWA: "Temporal expression profiling of DAMPs-related genes revealed the biphasic post-ischemic inflammation in the experimental stroke model", MOLECULAR BRAIN, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093029712, DOI: 10.1186/s13041-020-00598-1
MAEHARA NATSUMI, TANIGUCHI KAORI, OKUNO AMI, ANDO HIDEAKI, HIROTA AIKA, LI ZHIHENG, WANG CHING-TING, ARAI SATOKO, MIYAZAKI TORU: "AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke", CELL REPORTS, ELSEVIER INC, US, vol. 36, no. 11, 1 September 2021 (2021-09-01), US , pages 109693, XP093029713, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2021.109693
ZINDEL, JKUBES, P: "DAMPs, PAMPs, and LAMPs", IMMUNITY AND STERILE INFLAMMATION. ANNU. REV. PATHOL., vol. 15, 2020, pages 493 - 518
TREJO-GABRIEL-GALAN, J.M.: "Stroke as a complication and prognostic factor of COVID-19", NEUROLOGIA, vol. 35, 2020, pages 318 - 322
OXLEY, T.J.MOCCO, J.MAJIDI, S.KELLNER, C.P.SHOIRAH, H.SINGH, I.P.DE LEACY, R.A.SHIGEMATSU, T.LADNER, T.R.YAEGER, K.A. ET AL.: "Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young", N. ENGL. J. MED, vol. 382, 2020, pages e60
TAN, Y.K., GOH, C., LEOW, A.S.T., TAMBYAH, P.A., ANG, A., YAP, E.S., TU, T.M., SHARMA, V.K., YEO, L.L.L., CHAN, B.P.L. ET AL.: "COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature", J. THROMB. THROMBOLYSIS, vol. 50, 2020, pages 587 - 595, XP037254515, DOI: 10.1007/s11239-020-02228-y
GULKE, E.GELDERBLOM, MMAGNUS, T: "Danger signals in stroke and their role on microglia activation after ischemia", THER ADV. NEUROL. DISORD, vol. 11, 2018, pages 1756286418774254
CHAMORRO, A.DIRNAGL, U.URRA, X.PLANAS, A.M.: "Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosativestress, and inflammation", LANCET NEUROL, vol. 15, 2016, pages 869 - 881, XP029570829, DOI: 10.1016/S1474-4422(16)00114-9
LAND, W.G: "Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution", MOL. DIAGN. THER., vol. 24, 2020, pages 251 - 262
SANCHEZ, J.-C.: "Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction", SCI. REP, vol. 6, 2016, pages 38300
SHICHITA, S.ITO, M.MORITA, R.KOMAI, K.NOGUCHI, Y.OOBOSHI, H.KOSHIDA, Y.TAKAHASHI, S.KODAMA, TYOSHIMURA, A: "MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1", NAT MED., vol. 23, 2017, pages 723 - 732
ARAI, S.KITADA, K.YAMAZAKI, T.TAKAI, R.ZHANG, X.TSUGAWA, Y.SUGISAWA, R.MATSUMOTO, A.MORI, M.YOSHIHARA, Y. ET AL.: "Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice", NAT. MED., vol. 22, 2016, pages 183 - 193, XP055362476, DOI: 10.1038/nm.4012
TOMITA, T., ARAI, S., KITADA, K., MIZUNO, M., SUZUKI, Y., TOMITA, T., ARAI, S., KITADA, K., MIZUNO, M., SUZUKI, Y., SAKATA, F., NA: "Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice", SCI. REP, vol. 7, 2017, pages 6450
ARAI, SMIYAZAKI, T: "A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM", SEMIN. IMMUNOPATHOL., vol. 40, 2018, pages 567 - 575, XP036626557, DOI: 10.1007/s00281-018-0717-6
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
"GenBank", Database accession no. AF011428
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
IWATA N ET AL., SCI REP, vol. 3, 2013, pages 1472
JIANG ET AL.: "Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia", J. BIOL. CHEM., vol. 280, 2005, pages 33811 - 33818
ZOU, R ET AL.: "Electroacupuncture pretreatment attenuates Blood-Brain Barrier disruption following cerebral ischemia/reperfusion", MOL. MED. REP., vol. 12, 2015, pages 2027 - 2034
CHOI, K.H. ET AL.: "Overrexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation", ONCOTARGET, vol. 7, 2016, pages 67857 - 67867
UCHIDA ET AL.: "Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs", FREE RADIC. BIOL. MED, vol. 72, 2014, pages 156 - 161
KNOOPSET: "Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity", CELL CHEM. BIOL, vol. 25, 2018, pages 550 - 559
MIYAZAKI ET AL.: "Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily", J. EXP. MED., vol. 189, 1999, pages 413 - 422, XP008149323, DOI: 10.1084/jem.189.2.413
SARRIAS ET AL.: "A role for human Sp alpha as a pattern recognition receptor", J. BIOL. CHEM., vol. 280, 2005, pages 35391 - 35398, XP055578459, DOI: 10.1074/jbc.M505042200
ADEREMUNDERHILL: "Mechanisms of Phagocytosis in Macrophages", ANNU. REV. IMMUNOL., vol. 17, 1999, pages 593 - 623
CANTON ET AL.: "Scavenger receptors in homeostasis and immunity", NAT. REV. IMMUNOL., vol. 13, pages 621 - 634
ARAI SATOKO; MIYAZAKI TORU: "A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM)", SEMINARS IN IMMUNOPATHOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 40, no. 6, 11 October 2018 (2018-10-11), Berlin/Heidelberg, pages 567 - 575, XP036626557, ISSN: 1863-2297, DOI: 10.1007/s00281-018-0717-6
YAMAGUCHI ATSUSHI, JITSUISHI TATSUYA, HOZUMI TAKASHI, IWANAMI JUN, KITAJO KEIKO, YAMAGUCHI HIROO, MORI YASUTAKE, MOGI MASAKI, SAWA: "Temporal expression profiling of DAMPs-related genes revealed the biphasic post-ischemic inflammation in the experimental stroke model", MOLECULAR BRAIN, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093029712, DOI: 10.1186/s13041-020-00598-1
MAEHARA NATSUMI, TANIGUCHI KAORI, OKUNO AMI, ANDO HIDEAKI, HIROTA AIKA, LI ZHIHENG, WANG CHING-TING, ARAI SATOKO, MIYAZAKI TORU: "AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke", CELL REPORTS, ELSEVIER INC, US, vol. 36, no. 11, 1 September 2021 (2021-09-01), US , pages 109693, XP093029713, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2021.109693
ZINDEL, JKUBES, P: "DAMPs, PAMPs, and LAMPs", IMMUNITY AND STERILE INFLAMMATION. ANNU. REV. PATHOL., vol. 15, 2020, pages 493 - 518
TREJO-GABRIEL-GALAN, J.M.: "Stroke as a complication and prognostic factor of COVID-19", NEUROLOGIA, vol. 35, 2020, pages 318 - 322
OXLEY, T.J.MOCCO, J.MAJIDI, S.KELLNER, C.P.SHOIRAH, H.SINGH, I.P.DE LEACY, R.A.SHIGEMATSU, T.LADNER, T.R.YAEGER, K.A. ET AL.: "Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young", N. ENGL. J. MED, vol. 382, 2020, pages e60
TAN, Y.K., GOH, C., LEOW, A.S.T., TAMBYAH, P.A., ANG, A., YAP, E.S., TU, T.M., SHARMA, V.K., YEO, L.L.L., CHAN, B.P.L. ET AL.: "COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature", J. THROMB. THROMBOLYSIS, vol. 50, 2020, pages 587 - 595, XP037254515, DOI: 10.1007/s11239-020-02228-y
GULKE, E.GELDERBLOM, MMAGNUS, T: "Danger signals in stroke and their role on microglia activation after ischemia", THER ADV. NEUROL. DISORD, vol. 11, 2018, pages 1756286418774254
CHAMORRO, A.DIRNAGL, U.URRA, X.PLANAS, A.M.: "Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosativestress, and inflammation", LANCET NEUROL, vol. 15, 2016, pages 869 - 881, XP029570829, DOI: 10.1016/S1474-4422(16)00114-9
LAND, W.G: "Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution", MOL. DIAGN. THER., vol. 24, 2020, pages 251 - 262
SANCHEZ, J.-C.: "Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction", SCI. REP, vol. 6, 2016, pages 38300
SHICHITA, S.ITO, M.MORITA, R.KOMAI, K.NOGUCHI, Y.OOBOSHI, H.KOSHIDA, Y.TAKAHASHI, S.KODAMA, TYOSHIMURA, A: "MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1", NAT MED., vol. 23, 2017, pages 723 - 732
ARAI, S.KITADA, K.YAMAZAKI, T.TAKAI, R.ZHANG, X.TSUGAWA, Y.SUGISAWA, R.MATSUMOTO, A.MORI, M.YOSHIHARA, Y. ET AL.: "Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice", NAT. MED., vol. 22, 2016, pages 183 - 193, XP055362476, DOI: 10.1038/nm.4012
TOMITA, T., ARAI, S., KITADA, K., MIZUNO, M., SUZUKI, Y., TOMITA, T., ARAI, S., KITADA, K., MIZUNO, M., SUZUKI, Y., SAKATA, F., NA: "Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice", SCI. REP, vol. 7, 2017, pages 6450
ARAI, SMIYAZAKI, T: "A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM", SEMIN. IMMUNOPATHOL., vol. 40, 2018, pages 567 - 575, XP036626557, DOI: 10.1007/s00281-018-0717-6
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
"GenBank", Database accession no. AF011428
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
IWATA N ET AL., SCI REP, vol. 3, 2013, pages 1472
JIANG ET AL.: "Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia", J. BIOL. CHEM., vol. 280, 2005, pages 33811 - 33818
ZOU, R ET AL.: "Electroacupuncture pretreatment attenuates Blood-Brain Barrier disruption following cerebral ischemia/reperfusion", MOL. MED. REP., vol. 12, 2015, pages 2027 - 2034
CHOI, K.H. ET AL.: "Overrexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation", ONCOTARGET, vol. 7, 2016, pages 67857 - 67867
UCHIDA ET AL.: "Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs", FREE RADIC. BIOL. MED, vol. 72, 2014, pages 156 - 161
KNOOPSET: "Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity", CELL CHEM. BIOL, vol. 25, 2018, pages 550 - 559
MIYAZAKI ET AL.: "Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily", J. EXP. MED., vol. 189, 1999, pages 413 - 422, XP008149323, DOI: 10.1084/jem.189.2.413
SARRIAS ET AL.: "A role for human Sp alpha as a pattern recognition receptor", J. BIOL. CHEM., vol. 280, 2005, pages 35391 - 35398, XP055578459, DOI: 10.1074/jbc.M505042200
ADEREMUNDERHILL: "Mechanisms of Phagocytosis in Macrophages", ANNU. REV. IMMUNOL., vol. 17, 1999, pages 593 - 623
CANTON ET AL.: "Scavenger receptors in homeostasis and immunity", NAT. REV. IMMUNOL., vol. 13, pages 621 - 634
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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