Title:
SMALL MOLECULAR COMPOUND HAVING SUBSTITUTED PHENYLSPIRO[INDOLINE-3,3'-PYRROLIDINE] STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2024/078370
Kind Code:
A1
Abstract:
Disclosed in the present invention is a small molecular compound having a substituted phenylspiro[indoline-3,3'-pyrrolidine] structure. The structure thereof is as shown in general formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention can inhibit the protein-protein interaction between MDM2-p53 and MDMX-p53, is used as a small molecular inhibitor for the protein-protein interaction between MDM2-p53 and MDMX-p53, and is used in the preparation of a drug for preventing and/or treating diseases related to MDM2 and MDMX, especially tumors.
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Inventors:
ZHAO YUJUN (CN)
LI JIA (CN)
ZHOU YUBO (CN)
CHENG JING (CN)
YAN ZIQIN (CN)
LYU XILIN (CN)
ZHANG SHIYAN (CN)
ZHOU FEILONG (CN)
LIU CHEN (CN)
LIN ZHITONG (CN)
JIANG KAILONG (CN)
XU DEHUA (CN)
HU XIAOBEI (CN)
LI JIA (CN)
ZHOU YUBO (CN)
CHENG JING (CN)
YAN ZIQIN (CN)
LYU XILIN (CN)
ZHANG SHIYAN (CN)
ZHOU FEILONG (CN)
LIU CHEN (CN)
LIN ZHITONG (CN)
JIANG KAILONG (CN)
XU DEHUA (CN)
HU XIAOBEI (CN)
Application Number:
PCT/CN2023/123063
Publication Date:
April 18, 2024
Filing Date:
October 02, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D487/10; A61K31/407; A61P35/00
Foreign References:
| CN112912143A | 2021-06-04 | |||
| CN103298818A | 2013-09-11 | |||
| CN113788818A | 2021-12-14 | |||
| CN113387957A | 2021-09-14 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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