Title:
γ-SECRETASE INHIBITOR, Aβ-PEPTIDE PRODUCTION INHIBITOR, AND PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2024/004231
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel γ-secretase inhibitor that has as an active ingredient a substance for which a γ-secretase inhibitory activity is heretofore unknown. The present invention provides a γ-secretase inhibitor that contains a three-finger toxin.
Inventors:
FUTAI EUGENE (JP)
SAKAKIBARA RINA (JP)
SEKI MASAYOSHI (JP)
HIDAKA MASAFUMI (JP)
OGAWA TOMOHISA (JP)
SAKAKIBARA RINA (JP)
SEKI MASAYOSHI (JP)
HIDAKA MASAFUMI (JP)
OGAWA TOMOHISA (JP)
Application Number:
PCT/JP2022/041795
Publication Date:
January 04, 2024
Filing Date:
November 09, 2022
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K38/16; A61P25/28; A61P43/00; C07K14/46; C12N15/12
Other References:
DE SOUZA JESSICA M., GONCALVES BRUNO D. C., GOMEZ MARCUS V., VIEIRA LUCIENE B., RIBEIRO FABIOLA M.: "Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 9, 23 February 2018 (2018-02-23), CH , pages 145, XP093125249, ISSN: 1663-9812, DOI: 10.3389/fphar.2018.00145
LAHIRI DEBOMOY K: "Reversibility of the effect of tacrine on the secretion of the fl-amyloid precursor protein in cultured cells", NEUROSCIENCE LETTERS, vol. 181, no. 1-2, 1 January 1994 (1994-01-01), pages 149 - 152, XP093125255
KESSLER PASCAL, MARCHOT PASCALE, SILVA MARCELA, SERVENT DENIS: "The three‐finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 142, no. S2, 1 August 2017 (2017-08-01), GB , pages 7 - 18, XP093125258, ISSN: 0022-3042, DOI: 10.1111/jnc.13975
STEVEN D AIRD;YUTAKA WATANABE;ALEJANDRO VILLAR-BRIONES;MICHAEL C ROY;KOUKI TERADA;ALEXANDER S MIKHEYEV: "Quantitative high-throughput profiling of snake venom gland transcriptomes and proteomes (Ovophis okinavensis and Protobothrops flavoviridis)", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 14, no. 1, 14 November 2013 (2013-11-14), London, UK , pages 790, XP021167541, ISSN: 1471-2164, DOI: 10.1186/1471-2164-14-790
LAHIRI DEBOMOY K: "Reversibility of the effect of tacrine on the secretion of the fl-amyloid precursor protein in cultured cells", NEUROSCIENCE LETTERS, vol. 181, no. 1-2, 1 January 1994 (1994-01-01), pages 149 - 152, XP093125255
KESSLER PASCAL, MARCHOT PASCALE, SILVA MARCELA, SERVENT DENIS: "The three‐finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 142, no. S2, 1 August 2017 (2017-08-01), GB , pages 7 - 18, XP093125258, ISSN: 0022-3042, DOI: 10.1111/jnc.13975
STEVEN D AIRD;YUTAKA WATANABE;ALEJANDRO VILLAR-BRIONES;MICHAEL C ROY;KOUKI TERADA;ALEXANDER S MIKHEYEV: "Quantitative high-throughput profiling of snake venom gland transcriptomes and proteomes (Ovophis okinavensis and Protobothrops flavoviridis)", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 14, no. 1, 14 November 2013 (2013-11-14), London, UK , pages 790, XP021167541, ISSN: 1471-2164, DOI: 10.1186/1471-2164-14-790
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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