RECOMBINANT COLLAGEN AND USE THEREOF IN CARTILAGE REPAIR MATRIX

WIPO Patent Application WO/2024/074119

A1

A recombinant collagen and the use thereof in cartilage repair matrix. The recombinant collagen comprises a sequence as shown in SEQ ID No.1; the amino acid sequence of the recombinant collagen comprises N basic repeating units, and the basic repeating units contain N1 characteristic amino acid sequences as follows: "G-Xaa1-Xaa2-G-E-Xaa3"; and the 3' ends and the 5' ends of the basic repeating units are linked to form the above-mentioned characteristic amino acid sequence. The recombinant collagen has obvious integrin binding activity, has the effects of promoting cell adhesion, proliferation, differentiation, repairing defects of the cartilage tissue, etc., and has good application prospects.

WO/2021/225171	CHIMERIC PROTEIN CONTAINING FIBRINOGEN FRAGMENT AND LAMININ FRAGMENT, AND USE THEREOF
JP2015178526	RECOMBINANT LAMININ AND USE OF THE SAME
WO/2012/137970	MODIFIED LAMININ AND USE THEREOF

LIN HAI (CN)
XU YANG (CN)
WANG JING (CN)
LIU ZHANHONG (CN)
YANG XIA (CN)
ZHANG XINGDONG (CN)

PCT/CN2023/122682

April 11, 2024

September 28, 2023

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SHANXI JINBO BIOPHARMACEUTICAL CO LTD (CN)
UNIV SICHUAN (CN)

C07K14/78; A61L27/24; A61P19/00

CN115947827A	2023-04-11
CN109593126A	2019-04-09
CN113476593A	2021-10-08
CN103122027A	2013-05-29
CN113621052A	2021-11-09

IRAWAN, V. ET AL.: "Collagen Scaffolds in Cartilage Tissue Engineering and Relevant Approaches for Future Development", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 15, no. 6, 25 July 2018 (2018-07-25), XP036643684, DOI: 10.1007/s13770-018-0135-9

SHANGHAI SGLA LAW FIRM (CN)

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