Title:
PD-1 ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/089377
Kind Code:
A3
Abstract:
In some aspects, provided herein are antibodies that bind to PD-1. Antibodies provided herein, in some cases, agonize PD-1 signaling. Antibodies provided herein, in some cases, have modified Fc region. In other aspects, provided herein are compositions, methods of use, methods of making, and kits relating to antibodies that bind to PD-1.
Inventors:
PALUCH CHRISTOPHER (GB)
MURRAY LYNNE (GB)
MURRAY LYNNE (GB)
Application Number:
PCT/IB2022/000705
Publication Date:
July 13, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
MIROBIO LTD (GB)
International Classes:
C07K16/28; A61P37/06; A61K39/00
Domestic Patent References:
| WO2018226580A2 | 2018-12-13 | |||
| WO2010029434A1 | 2010-03-18 | |||
| WO2011110621A1 | 2011-09-15 | |||
| WO2019168745A1 | 2019-09-06 | |||
| WO2017058859A1 | 2017-04-06 | |||
| WO2020247648A2 | 2020-12-10 |
Other References:
CURNOCK ADAM P. ET AL: "Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors", JCI INSIGHT, vol. 6, no. 20, E152468, 22 October 2021 (2021-10-22), XP093021891, Retrieved from the Internet [retrieved on 20230208], DOI: 10.1172/jci.insight.152468
KEHRY MARILYN: "Discovery of a PD-1 Checkpoint Agonist Antibody for Autoimmune/Inflammatory Disease", ANAPTYSBIO, 2 March 2020 (2020-03-02), pages 1 - 16, XP093004746, Retrieved from the Internet [retrieved on 20221205]
LIU RENA ET AL: "Fc-Engineering for Modulated Effector Functions-Improving Antibodies for Cancer Treatment", ANTIBODIES, vol. 9, no. 4, 17 December 2020 (2020-12-17), CH, pages 64, XP055918764, ISSN: 2073-4468, DOI: 10.3390/antib9040064
F. MIMOTO ET AL: "Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131", PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 26, no. 10, 5 June 2013 (2013-06-05), pages 589 - 598, XP055087986, ISSN: 1741-0126, DOI: 10.1093/protein/gzt022
KEHRY MARILYN: "Discovery of a PD-1 Checkpoint Agonist Antibody for Autoimmune/Inflammatory Disease", ANAPTYSBIO, 2 March 2020 (2020-03-02), pages 1 - 16, XP093004746, Retrieved from the Internet
LIU RENA ET AL: "Fc-Engineering for Modulated Effector Functions-Improving Antibodies for Cancer Treatment", ANTIBODIES, vol. 9, no. 4, 17 December 2020 (2020-12-17), CH, pages 64, XP055918764, ISSN: 2073-4468, DOI: 10.3390/antib9040064
F. MIMOTO ET AL: "Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131", PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 26, no. 10, 5 June 2013 (2013-06-05), pages 589 - 598, XP055087986, ISSN: 1741-0126, DOI: 10.1093/protein/gzt022
Attorney, Agent or Firm:
CARPMAELS & RANSFORD LLP (GB)
Download PDF:
Previous Patent: METHOD FOR SIMULATING DENTAL IMAGES THAT INCLUDE TOOTH ROOTS
Next Patent: GEARING ARRANGEMENT, LONGITUDINAL ADJUSTER AND VEHICLE SEAT
Next Patent: GEARING ARRANGEMENT, LONGITUDINAL ADJUSTER AND VEHICLE SEAT