Title:
NOVEL USE OF PBMC-DERIVED CYTOTOXIC T CELLS
Document Type and Number:
WIPO Patent Application WO/2023/244055
Kind Code:
A1
Abstract:
The present invention relates to: a method for evaluating the efficacy of an anticancer drug using a mixture of peripheral blood mononuclear cells (PBMCs) and cancer organoids; a method for screening the anticancer drug; a system for evaluating the efficacy of the anticancer drug; or a system for screening the anticancer drug. Specifically, the present invention relates to: a method for evaluating the efficacy of an anticancer drug using a mixture of cytotoxic T cells differentiated from PBMCs and cancer organoids; a method for screening the anticancer drug; a system for evaluating the efficacy of the anticancer drug; or a system for screening the anticancer drug. The method for evaluating the efficacy of an anticancer drug, the screening method, the efficacy evaluation system, or the screening system according to the present invention can very closely reproduce a tumor microenvironment, which is the form in which cancer cells exist in a living body. In addition, since PBMCs derived from a normal individual are used through differentiation into cytotoxic T cells specific to a cancer patient, the burden of collecting biological samples such as blood and tissue samples from the cancer patient can be reduced, and the efficacy of an anticancer drug can be evaluated with high accuracy.
Inventors:
LEE BO EUN (KR)
KIM SARANG (KR)
KIM DONG HYEON (KR)
LEE HYEJI (KR)
KIM EUN JEONG (KR)
KIM SARANG (KR)
KIM DONG HYEON (KR)
LEE HYEJI (KR)
KIM EUN JEONG (KR)
Application Number:
PCT/KR2023/008325
Publication Date:
December 21, 2023
Filing Date:
June 15, 2023
Export Citation:
Assignee:
ORGANOIDSCIENCES LTD (KR)
International Classes:
G01N33/50
Domestic Patent References:
| WO2021075528A1 | 2021-04-22 |
Foreign References:
| KR20200105852A | 2020-09-09 | |||
| US20220064597A1 | 2022-03-03 | |||
| KR102511631B1 | 2023-03-20 |
Other References:
KRIJN K. DIJKSTRA, CHIARA M. CATTANEO, FLEUR WEEBER, MYRIAM CHALABI, JORIS VAN DE HAAR, LORENZO F. FANCHI, MAARTEN SLAGTER, DAPHNE: "Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids", CELL, ELSEVIER, AMSTERDAM NL, vol. 174, no. 6, 1 September 2018 (2018-09-01), Amsterdam NL , pages 1 - 26, XP055722242, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.07.009
Attorney, Agent or Firm:
IPSCENT (KR)
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