Title:
IMMUNE CELLS WITH COMBINATION GENE PERTURBATIONS
Document Type and Number:
WIPO Patent Application WO/2024/059824
Kind Code:
A3
Abstract:
Provided herein are recombinant nucleic acids that reduce expression of CD5, CBLB, CISH, DGKA, DGKZ, DNMT3A, MAP4K1, NR4A1, PTPN2, TET2, or ZC3H12A and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.
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Inventors:
LITTERMAN ADAM (US)
SINGH BRENAL (US)
GAGNON JOHN (US)
DETOMASO DAVID (US)
CASS ASHLEY (US)
GRAY-RUPP LEVI (US)
WILLIAMS SAMUEL (US)
SINGH BRENAL (US)
GAGNON JOHN (US)
DETOMASO DAVID (US)
CASS ASHLEY (US)
GRAY-RUPP LEVI (US)
WILLIAMS SAMUEL (US)
Application Number:
PCT/US2023/074352
Publication Date:
April 25, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
ARSENAL BIOSCIENCES INC (US)
International Classes:
C12N15/113
Domestic Patent References:
| WO2020150534A2 | 2020-07-23 | |||
| WO2022056459A1 | 2022-03-17 | |||
| WO2021062227A2 | 2021-04-01 |
Other References:
M. A. SARHAN ET AL: "Hepatitis C Virus Infection of Human T Lymphocytes Is Mediated by CD5", JOURNAL OF VIROLOGY, vol. 86, no. 7, 25 January 2012 (2012-01-25), US, pages 3723 - 3735, XP055562009, ISSN: 0022-538X, DOI: 10.1128/JVI.06956-11
Attorney, Agent or Firm:
LANGE, Kevin et al. (US)
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