Title:
GENE EXPRESSION REGULATOR, PROPHYLACTIC DRUG OR THERAPEUTIC DRUG FOR ALZHEIMER'S DISEASE, AND METHOD FOR IMPROVING DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2023/182243
Kind Code:
A1
Abstract:
The gene expression regulator is a microparticle that contains miRNA for which the target gene is a gene related to the expression of at least one protein from amyloid precursor protein (APP), β-secretase (BACE1), NMDA-activating protein, glycogen synthetase kinase-3β (GSK-3β), and polyglutamine-binding protein-1 (PQBP1). This can provide a novel gene expression regulator that can regulate (e.g., inhibit or suppress) the expression of protein involved in amyloid β-associated or tau protein-associated dementias, e.g., Alzheimer's disease, and/or in cerebral inflammation. Also provided is a prophylactic drug or a therapeutic drug for Alzheimer's disease and a method for improving dementia.
Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2023/010775
Publication Date:
September 28, 2023
Filing Date:
March 19, 2023
Export Citation:
Assignee:
DEXON PHARMACEUTICALS INC (JP)
International Classes:
A61K31/7105; A61K48/00; A61K35/32; A61P25/28; A61P43/00; C12N15/113
Domestic Patent References:
| WO2021003403A1 | 2021-01-07 |
Foreign References:
| US20210002650A1 | 2021-01-07 |
Other References:
JAHANGARD YAVAR, MONFARED HAMIDEH, MORADI ARMAN, ZARE MEYSAM, MIRNAJAFI-ZADEH JAVAD, MOWLA SEYED JAVAD: "Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer’s Disease", FRONTIERS IN NEUROSCIENCE, vol. 14, XP093095089, DOI: 10.3389/fnins.2020.00564
GIZAK AGNIESZKA, DUDA PRZEMYSŁAW, PIELKA EWA, MCCUBREY JAMES A., RAKUS DARIUSZ: "GSK3 and miRNA in neural tissue: From brain development to neurodegenerative diseases", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1867, no. 7, 1 July 2020 (2020-07-01), NL , pages 118696, XP093095090, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2020.118696
JIN MEIHUA, SHIWAKU HIROKI, TANAKA HIKARI, OBITA TAKAYUKI, OHUCHI SAKURAKO, YOSHIOKA YUKI, JIN XIAOCEN, KONDO KANOH, FUJITA KYOTA,: "Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093095093, DOI: 10.1038/s41467-021-26851-2
ANOOP MINU, DATTA INDRANI: "Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHED) in Neuronal Disorders: A Review", CURRENT STEM CELL RESEARCH & THERAPY, SAIF ZONE, SHARJAH [U.A.] : BENTHAM, AE, vol. 16, no. 5, 7 December 2021 (2021-12-07), AE , pages 535 - 550, XP009549671, ISSN: 1574-888X, DOI: 10.2174/1574888X16666201221151512
GIZAK AGNIESZKA, DUDA PRZEMYSŁAW, PIELKA EWA, MCCUBREY JAMES A., RAKUS DARIUSZ: "GSK3 and miRNA in neural tissue: From brain development to neurodegenerative diseases", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1867, no. 7, 1 July 2020 (2020-07-01), NL , pages 118696, XP093095090, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2020.118696
JIN MEIHUA, SHIWAKU HIROKI, TANAKA HIKARI, OBITA TAKAYUKI, OHUCHI SAKURAKO, YOSHIOKA YUKI, JIN XIAOCEN, KONDO KANOH, FUJITA KYOTA,: "Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093095093, DOI: 10.1038/s41467-021-26851-2
ANOOP MINU, DATTA INDRANI: "Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHED) in Neuronal Disorders: A Review", CURRENT STEM CELL RESEARCH & THERAPY, SAIF ZONE, SHARJAH [U.A.] : BENTHAM, AE, vol. 16, no. 5, 7 December 2021 (2021-12-07), AE , pages 535 - 550, XP009549671, ISSN: 1574-888X, DOI: 10.2174/1574888X16666201221151512
Attorney, Agent or Firm:
SUGAWARA Tetsuro (JP)
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