Title:
ANTIBODY, NUCLEIC ACID, CELL, AND PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2024/085081
Kind Code:
A1
Abstract:
Provided is an antibody that specifically binds to the extracellular domain of human LPA1 but does not specifically bind to the extracellular domain of human LPA2 or the extracellular domain of human LPA3. The antibody preferably has activity to block LPA1-dependent cellular function. Also provided are: an nucleic acid encoding the antibody; a cell containing sthe nucleic acid; and a pharmaceutical containing the antibody as an active ingredient.
Inventors:
HIKICHI MEGUMI (JP)
ASHIDA MASAMI (JP)
NAKAGAWA MIKI (JP)
SHINAGAWA MASAHIKO (JP)
TANAKA RYOMA (JP)
TAKAYAMA KIYOSHI (JP)
AOKI JUNKEN (JP)
ASHIDA MASAMI (JP)
NAKAGAWA MIKI (JP)
SHINAGAWA MASAHIKO (JP)
TANAKA RYOMA (JP)
TAKAYAMA KIYOSHI (JP)
AOKI JUNKEN (JP)
Application Number:
PCT/JP2023/037183
Publication Date:
April 25, 2024
Filing Date:
October 13, 2023
Export Citation:
Assignee:
NB HEALTH LABORATORY CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C12N15/13; A61K39/395; A61K47/68; A61P1/00; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P25/04; A61P27/02; A61P29/00; A61P35/00; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| WO2005009469A1 | 2005-02-03 | |||
| WO2004044580A1 | 2004-05-27 |
Foreign References:
| US20230181671A1 | 2023-06-15 | |||
| JP2008546387A | 2008-12-25 |
Other References:
FERNAND GOBEIL: "Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 278, no. 40, 1 October 2003 (2003-10-01), US , pages 38875 - 38883, XP093160454, ISSN: 0021-9258, DOI: 10.1074/jbc.M212481200
JI HAE JUNG; SEONG‐GU HAN; MAN‐SEOK JU; SANG TAEK JUNG; YEON GYU YU: "Isolation of Single Chain Antibodies Specific to Lysophosphatidic Acid Receptor 1 (LPA1) from a M13 Phage Display Library Using Purified LPA1 Stabilized in Nanodiscs", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 40, no. 7, 8 May 2019 (2019-05-08), Hoboken, USA, pages 680 - 685, XP072013768, ISSN: 1229-5949, DOI: 10.1002/bkcs.11751
YUHUA ZHENG: "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen‐activated human blood T lymphocytes", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 14, no. 15, 1 December 2000 (2000-12-01), US, pages 2387 - 2389, XP093160455, ISSN: 0892-6638, DOI: 10.1096/fj.00-0492fje
LYGIA T. BUDNIK: "Lysophosphatidic Acid Signals through Mitogen-Activated Protein Kinase-Extracellular Signal Regulated Kinase in Ovarian Theca Cells Expressing the LPA1/edg2-Receptor: Involvement of a Nonclassical Pathway?", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 17, no. 8, 1 August 2003 (2003-08-01), US , pages 1593 - 1606, XP093160456, ISSN: 0888-8809, DOI: 10.1210/me.2002-0371
JI HAE JUNG; SEONG‐GU HAN; MAN‐SEOK JU; SANG TAEK JUNG; YEON GYU YU: "Isolation of Single Chain Antibodies Specific to Lysophosphatidic Acid Receptor 1 (LPA1) from a M13 Phage Display Library Using Purified LPA1 Stabilized in Nanodiscs", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 40, no. 7, 8 May 2019 (2019-05-08), Hoboken, USA, pages 680 - 685, XP072013768, ISSN: 1229-5949, DOI: 10.1002/bkcs.11751
YUHUA ZHENG: "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen‐activated human blood T lymphocytes", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 14, no. 15, 1 December 2000 (2000-12-01), US, pages 2387 - 2389, XP093160455, ISSN: 0892-6638, DOI: 10.1096/fj.00-0492fje
LYGIA T. BUDNIK: "Lysophosphatidic Acid Signals through Mitogen-Activated Protein Kinase-Extracellular Signal Regulated Kinase in Ovarian Theca Cells Expressing the LPA1/edg2-Receptor: Involvement of a Nonclassical Pathway?", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 17, no. 8, 1 August 2003 (2003-08-01), US , pages 1593 - 1606, XP093160456, ISSN: 0888-8809, DOI: 10.1210/me.2002-0371
Attorney, Agent or Firm:
FUJITA Takashi et al. (JP)
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