Title:
ANTIBODY FOR DETECTING MULTIPLE ANTIGENS
Document Type and Number:
WIPO Patent Application WO/2024/034543
Kind Code:
A1
Abstract:
Provided is a variant of an antibody, wherein: a conserved amino acid residue present in a base part (CDR loop base part) in a loop structure of a complementarity determining region (CDR) of the antibody is modified into another kind of amino acid residue; the conserved amino acid residue is at least one kind selected from the group consisting of a tyrosine residue, a phenylalanine residue, a tryptophan residue, a leucine residue, a serine residue, a valine residue, an arginine residue, and a threonine residue; and the binding half-life of the variant of the antibody to an antigen due to dissociation is at most 180 seconds.
Inventors:
WATANABE NAOKI (JP)
MIYAMOTO AKITOSHI (JP)
ZHANG QIANLI (JP)
MIYAMOTO AKITOSHI (JP)
ZHANG QIANLI (JP)
Application Number:
PCT/JP2023/028634
Publication Date:
February 15, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07K16/00; C12N15/13
Domestic Patent References:
| WO2016143900A1 | 2016-09-15 |
Foreign References:
| JP2013518131A | 2013-05-20 |
Other References:
K. VERBEKE, A. GILS, P. J. DECLERCK: "Cloning and paratope analysis of an antibody fragment, a rational approach for the design of a PAI-1 inhibitor", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUB., C2003-, vol. 2, no. 2, 1 February 2004 (2004-02-01), pages 289 - 297, XP055082582, ISSN: 15387933, DOI: 10.1111/j.1538-7933.2004.00582.x
SHANDILYA SHIVENDER, KURT YILMAZ NESE, SADOWSKI ANDREW, MONIR EJEMEL, SCHILLER ZACHARY A., THOMAS WILLIAM D., KLEMPNER MARK S., SC: "Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.", JOURNAL OF MOLECULAR RECOGNITION., HEYDEN & SON LTD., LONDON., GB, vol. 30, no. 5, 1 May 2017 (2017-05-01), GB , XP093137590, ISSN: 0952-3499, DOI: 10.1002/jmr.2595
AKIBA HIROKI, TAMURA HIROKO, KIYOSHI MASATO, YANAKA SAEKO, SUGASE KENJI, CAAVEIRO JOSE M. M., TSUMOTO KOUHEI: "Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, US , XP093137592, ISSN: 2045-2322, DOI: 10.1038/s41598-019-50722-y
SHANDILYA SHIVENDER, KURT YILMAZ NESE, SADOWSKI ANDREW, MONIR EJEMEL, SCHILLER ZACHARY A., THOMAS WILLIAM D., KLEMPNER MARK S., SC: "Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.", JOURNAL OF MOLECULAR RECOGNITION., HEYDEN & SON LTD., LONDON., GB, vol. 30, no. 5, 1 May 2017 (2017-05-01), GB , XP093137590, ISSN: 0952-3499, DOI: 10.1002/jmr.2595
AKIBA HIROKI, TAMURA HIROKO, KIYOSHI MASATO, YANAKA SAEKO, SUGASE KENJI, CAAVEIRO JOSE M. M., TSUMOTO KOUHEI: "Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, US , XP093137592, ISSN: 2045-2322, DOI: 10.1038/s41598-019-50722-y
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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