Title:
ANTIBODIES, ANTIBODY-DRUG CONJUGATES, PREPARATIONS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/083162
Kind Code:
A1
Abstract:
Provided are the antibodies specific targeting CD142, antibody-drug conjugates, preparations and uses thereof. The antibody or antigen-binding fragment thereof binding to CD142 is covalently linked to a cytotoxic payload through a linker. The antibody or antigen-binding fragment thereof binding to CD142 and the antibody-drug conjugate exhibit cytotoxic effects on tumor cells.
Inventors:
MENG XUN (CN)
LIU SHU-HUI (CN)
ZHANG YUE (CN)
LIU SHU-HUI (CN)
ZHANG YUE (CN)
Application Number:
PCT/CN2023/125261
Publication Date:
April 25, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
MULTITUDE THERAPEUTICS INC (CN)
International Classes:
C07K16/28; A61K39/395; A61K47/68; A61P35/00; C12N15/13
Domestic Patent References:
| WO2020236841A2 | 2020-11-26 | |||
| WO2022115451A1 | 2022-06-02 | |||
| WO2022115477A1 | 2022-06-02 | |||
| WO2011157741A2 | 2011-12-22 |
Foreign References:
| CN112094346A | 2020-12-18 |
Other References:
SU, Z. ET AL.: "Antibody-drug conjugates: Recent advances in linker chemistry", ACTA PHARMACEUTICA SINICA B, vol. 11, no. 12, 31 December 2021 (2021-12-31), pages 3889 - 3907, XP093087740, DOI: 10.1016/j.apsb.2021.03.042
CONILH, L. ET AL.: "Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform", PHARMACEUTICALS, vol. 14, 9 March 2021 (2021-03-09), XP055953984, DOI: 10.3390/ph14030247
WEINING WENG: "AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 22, no. 9, 5 September 2023 (2023-09-05), US , pages 1013 - 1027, XP093161097, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-23-0198
CHAO KONG: "MTX-13, a Novel PTK7-Directed Antibody–Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 22, no. 10, 2 October 2023 (2023-10-02), US , pages 1128 - 1143, XP093161101, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-23-0164
WENG WEINING, MENG TAO, ZHAO QIANQIAN, SHEN YI, FU GUOXIANG, SHI JING, ZHANG YUE, WANG ZHAOHUI, WANG MINGQIAO, PAN RONG, MA LINJIE: "Antibody–Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 4, 3 April 2023 (2023-04-03), US , pages 950 - 973, XP093105413, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-22-1368
CONILH, L. ET AL.: "Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform", PHARMACEUTICALS, vol. 14, 9 March 2021 (2021-03-09), XP055953984, DOI: 10.3390/ph14030247
WEINING WENG: "AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 22, no. 9, 5 September 2023 (2023-09-05), US , pages 1013 - 1027, XP093161097, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-23-0198
CHAO KONG: "MTX-13, a Novel PTK7-Directed Antibody–Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 22, no. 10, 2 October 2023 (2023-10-02), US , pages 1128 - 1143, XP093161101, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-23-0164
WENG WEINING, MENG TAO, ZHAO QIANQIAN, SHEN YI, FU GUOXIANG, SHI JING, ZHANG YUE, WANG ZHAOHUI, WANG MINGQIAO, PAN RONG, MA LINJIE: "Antibody–Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 4, 3 April 2023 (2023-04-03), US , pages 950 - 973, XP093105413, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-22-1368
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
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