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WO/2024/018003A1 |
EVs are being recognized as vectors for drug delivery. In particular, EV loading with targeting and therapeutic agents brings along an interesting opportunity to translate EVs into a bio-mimetic selective delivery system. Indeed, EVs con...
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WO/2024/019355A1 |
The present invention relates to a gene construct characterized by encoding a fusion protein of flgM and strep-tag, wherein an anti-sigma factor flgM gene and a strep-tag-encoding gene are linked whereby the strep-tag can be expressed on...
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WO/2024/019516A1 |
The present invention relates to a method for cultivating microalgae, and the method for cultivating microalgae according to the present invention comprises: a step (S100) of injecting a KOH aqueous solution into a reaction vessel and su...
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WO/2024/019378A1 |
The present invention relates to a recombinant expression vector for conantokin-G secretion and an attenuated Salmonella strain transformed therewith, and provides: an attenuated Salmonella strain transformed with a recombinant expressio...
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WO/2024/020466A1 |
The disclosure relates to methods and compositions that provide for bacterial populations with increased potential for engraftment into the gut of mammalian systems. Accordingly, aspects of the disclosure relate to a bacterial cell or po...
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WO/2024/018036A1 |
The present invention relates to a platform based on unicellular algae, grown in a controlled environment, which serve as a biofactory for the production of biologically active metabolites.
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WO/2024/020197A1 |
The present disclosure provides pharmaceutical compositions comprising a microorganism capable of expressing one or more enzymes that convert salicin to saligenin, and salicin, or a pharmaceutically acceptable salt thereof. The present d...
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WO/2024/018434A1 |
The present disclosure relates to a Bacillus velezensis strain, and a composition for plant protection comprising an effective amount of said Bacillus velezensis. The use of the disclosed Bacillus velezensis strain or composition as a bi...
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WO/2024/019377A1 |
The present invention relates to a recombinant expression vector for melittin secretion and an attenuated Salmonella strain transformed therewith, and provides an attenuated Salmonella strain transformed with a recombinant expression vec...
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WO/2024/020528A1 |
Methods and compositions for use in growth of pink-pigmented facultative methylotrophs (PPFM) and/or methanotroph bacteria are provided herein, wherein the fermentation comprises hop acids to inhibit growth of bacterial contaminants.
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WO/2024/018037A1 |
The present invention relates to a microalgae product capable of expressing glucagon-like peptide (GLP), preferably GLP-2, and its use in the pharmaceutical or nutraceutical field in the treatment and prevention of disorders affecting th...
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WO/2024/020530A1 |
The present invention is directed to compositions and methods for production of UDP-sugars, including UDP-glucose and UDP-galactose. In particular, the invention provides engineered cell lines for production of UDP-sugars and methods of ...
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WO/2024/020439A1 |
A hydrogel is provided comprising a first polymer, a second polymer, and a crosslinker. The first polymer comprises at least one ester-containing moiety and at least one first crosslinking moiety. The second polymer comprises at least on...
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WO/2024/017318A1 |
The present application belongs to the technical field of microorganisms and provides Ralstonia eutropha having low endotoxin content and a use thereof. Further provided is a use of the reduction of enzymatic activity and/or expression o...
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WO/2024/018971A1 |
The purpose of the present invention is to accurately calculate the number of cells. A cell culture device 1 comprises a sensor 26 for measuring the lactic acid concentration in a medium. The sensor 26 measures the concentration of lacti...
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WO/2024/017371A1 |
The present invention relates to a multispecific antibody, such as a bispecific antibody, comprising a mutated amino acid pair capable of promoting homologous pairing of a heavy chain and a light chain of the multispecific antibody.
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WO/2024/020353A1 |
Disclosed herein include methods for improving plant health by heterologously disposing one or more endophytes to a plant element in an effective amount to improve a trait of agronomic importance in a plant derived from the treated plant...
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WO/2024/019216A1 |
The present invention relates to a microorganism of the genus Corynebacterium having an improved ability to produce L-arginine or L-citrulline, and to a method for producing L-arginine or L-citrulline using same. The variant of the genus...
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WO/2024/018061A1 |
Chronic obstructive pulmonary disease is a major clinical challenge mostly due to cigarette smoke exposure and affects more than 200 million people. The inventors tested if exposure to the Bordetella pertussis BPZE1 stain could modulate ...
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WO/2024/018304A1 |
This invention concerns a recombinant non-naturally occurring methylotrophic microorganism, which grows on reduced one-carbon (C1) compounds as sole carbon source. The recombinant microorganism expresses or over-expresses a polypeptide h...
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WO/2024/015884A1 |
This invention relates to compositions and methods for improving plant health, wherein a plant is heterologously disposed to one or more endophytes, or derived from a plant element heterologously disposed to one or more endophytes.
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WO/2024/013721A1 |
The present disclosure relates to methods and systems for extending metabolism of algal biomass or enzyme extracts, including the production and extraction of algal secondary metabolites with pharmaceutical, industrial, and agricultural ...
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WO/2024/012141A1 |
A feed additive rich in stachyose extract and Bacillus licheniformis, and a preparation method therefor. The method comprises: crushing Stachys japonica, Rehmanniae radix, and Stachys floridana to obtain a mixed dry powder, adding ethano...
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WO/2024/013376A1 |
The present invention provides new isolated strains of the microorganism Ligilactobacillus salivarius, compositions comprising it and uses thereof in the prevention and/or treatment of infertility and infection diseases as well as non-th...
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WO/2024/014882A1 |
The present invention relates to: a Bacillus coagulans PA strain for producing a large amount of polyamine; and a polyamine preparation method using same. The Bacillus coagulans PA strain of the present invention proliferates in anaerobi...
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WO/2024/011948A1 |
Provided are a high-efficiency levonorgestrel-degrading strain and the use thereof. The strain is Gordonia sp. H52 with the deposit number GDMCC No: 62995. The strain degrades levonorgestrel at a fast rate, can be used for degrading levo...
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WO/2024/015365A1 |
Food products are provided in which microbial protein sources, such as single cell protein or protein hydrolysis products, are incorporated, and which contain proteins that are recombinantly expressed in chemoautotrophic microorganisms. ...
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WO/2024/014696A1 |
The present invention relates to: an L-glutamic acid-producing mutant microorganism of the genus Corynebacterium; and a method for producing L-glutamic acid using same. More specifically, the present invention relates to: a novel variant...
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WO/2024/015480A1 |
Provided herein are methods and systems to selectively deplete a biological sample of host compartments and/or host nucleic acid while enriching the sample microbial compartments and/or related microbial nucleic acid. In addition, provid...
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WO/2024/011666A1 |
A recombinant Escherichia coli modified by metabolic engineering means and a method for producing L-homoserine by using same. The strain is Escherichia coli having a strain number of 13-XA, and is deposited in China General Microbiologic...
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WO/2024/014699A1 |
The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method for producing L-glutamic acid using same and, more specifically, to a novel mutant redox enzyme involved in the L-glutamic...
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WO/2024/014517A1 |
A cell culture method including a culture step for culturing cells, said cells being in contact with a collagen gel containing type III collagen; a production method of a therapeutic composition including a culture step for culturing cel...
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WO/2024/015152A1 |
Non-plant cells that produce tetrahydropapaverine (THP) via an engineered THP-biosynthetic pathway are provided. In embodiments of the invention, the engineered THP-biosynthetic pathway is a norreticuline mediated pathway. Also provided ...
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WO/2024/014698A1 |
The present invention relates to a mutant microorganism of the genus Corynebacterium which produces L-glutamic acid and a method for producing L-glutamic acid using same. More specifically, the present invention relates to a novel malate...
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WO/2024/014501A1 |
To provide an antibody or an antigen-binding fragment thereof that is useful in testing for cancer, especially early cancer. An antibody, or an antigen-binding fragment thereof, that includes a heavy chain CDR1 including an amino acid se...
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WO/2024/013277A1 |
The present disclosure relates to a method for preparing a fermented edible product enriched or improved in one or more properties selected from flavour, aroma, texture, cooking experience, visual appearance, nutritional and/or dietary v...
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WO/2024/015886A2 |
A microbiological process for conversion of CO2 into one or more bio-products, the process comprising the steps of: i. contacting raw carbon dioxide and sulfur-containing feedstocks in one or more gas contactor or absorption columns with...
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WO/2024/011761A1 |
Disclosed in the present invention are ecgonone transmethylases EnEMT1 and EnEMT2 from Erythroxylaceae, and genes thereof and the use thereof. EnEMT1 has an amino acid sequence as shown in SEQ ID NO. 4 and a nucleotide sequence as shown ...
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WO/2024/015307A1 |
Provided herein are seed treatment formulations that provide improved growth and yield in the plants grown from seeds treated with such formulations, as well as methods of use.
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WO/2024/015944A1 |
This invention relates to compositions and methods for improving plant health, wherein a plant is heterologously disposed to one or more endophytes, or derived from a plant element heterologously disposed to one or more endophytes.
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WO/2024/008214A1 |
Disclosed in the present application is a preparation method for an ionic rare earth leaching agent. The preparation method comprises the following steps: (1) domesticating microorganisms by using a rare earth activated mineral powder cu...
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WO/2024/011207A1 |
The subject invention provides compositions and methods for reducing enteric methane in livestock animals' digestive systems and/or waste. In preferred embodiments, a composition comprising an iron-capturing ingredient is contacted with ...
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WO/2024/007055A1 |
A method of producing modified bacteriophage ("phage") that are capable of infecting and causing lysis of a parent host bacteria that is insensitive to the unmodified phage is disclosed. The method comprises: treating a host bacteria ins...
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WO/2024/009249A1 |
The present invention relates to an aid for the preparation of doughs for baked food products. Such aid comprises a food-grade carrier for baked food products and microcapsules containing viable lactic acid bacteria belonging to at least...
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WO/2024/008046A1 |
A strain and a use thereof in the production of a β-nicotinamide mononucleotide (NMN). Disclosed is a strain of Escherichia coli, the accession number of the strain being CCTCC M2022922. Disclosed is a new strain for producing a β-NMN,...
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WO/2024/010074A1 |
The present invention provides a protein having an amino acid sequence of SEQ ID NO: 2 and a mutant thereof, a polynucleotide encoding the protein, a transformant including the polynucleotide, and a steviol glycoside using the protein an...
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WO/2024/010529A1 |
Disclosed herein is a method of producing an enantiomerically pure or enantiomerically enriched alcohol, acid or amine from a racemic 2-alkyl-3-phenyl oxirane or derivative thereof and/or a racemic 2-alkyl-2-phenyl oxirane or derivative ...
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WO/2024/007079A1 |
Probiotic bacteria isolated from phytoplankton biomass are provided. The probiotic bacteria may be in the form of at least one isolated strain. In some embodiments, the probiotic bacteria are for use as probiotics in mammals, including h...
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WO/2024/008205A1 |
The present invention belongs to the technical fields of genetic engineering and enzyme engineering, and specifically relates to the use of MmBBK2 in the preparation of trypsin and chymotrypsin inhibitors. The MmBBK2 has an amino acid se...
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WO/2024/008204A1 |
Provided is the use of MmPI in the preparation of a trypsin inhibitor. The amino acid sequence of the MmPI is as shown in SEQ ID NO. 1. In the present invention, it is confirmed that MmPI in mulberry leaves has a trypsin inhibitory activ...
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