Title:
USE OF COCLAURINE AND DERIVATIVE THEREOF IN IMPROVING NAMPT ACTIVITY AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/092959
Kind Code:
A1
Abstract:
Provided are use of Coclaurine and a derivative thereof in improving NAMPT activity and a pharmaceutical composition. By screening for drug molecule monomers of natural products with NAMPT activation activity using a biological fluorescence resonance energy transfer probe, it is found that Coclaurine and the derivative thereof not only improve the NAMPT activity, but also have no toxicity when they are at the same concentration as an artificially synthesized molecule. The use of Coclaurine and the derivative thereof as a new strategy can improve the NAMPT activity, thereby improving the NAD+ level of a cell, delaying the aging of the cell and an individual, and having great potential in the treatment of a neurodegenerative disease.
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Inventors:
WANG PEI (CN)
YU QIULIYANG (CN)
YU QIULIYANG (CN)
Application Number:
PCT/CN2022/137377
Publication Date:
May 10, 2024
Filing Date:
December 07, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K31/472; A61P25/28
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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