Title:
SYNTHESIS AND USE OF LIPID-COUPLED COMPLETELY-DEGRADABLE WATER-SOLUBLE POLYMER
Document Type and Number:
WIPO Patent Application WO/2024/055681
Kind Code:
A1
Abstract:
Disclosed in the present invention are the synthesis of a lipid-coupled completely-degradable water-soluble polymer, and the use of the lipid-coupled completely-degradable water-soluble polymer in drug delivery. The structural formula is as shown in formula (I). The lipid-PPE molecule designed in the present invention has a hydrophobic lipid tail and a hydrophilic head, and can be used together with other existing lipid molecules to prepare RNA-encapsulated LNPs so as to efficiently complete the delivery of RNA. Repeating units of phosphoester bonds are introduced into the lipid-PPE molecule, so that the lipid-PPE molecule is easily degraded into small molecular monomers when entering organisms, thereby reducing inflammatory reactions. Liposomes or LNPs formed by combining degradable lipid-PPE and other lipid molecules can alleviate the antibody reaction and hepatotoxicity caused by traditional liposomes containing polyethylene glycol (PEG) after multiple injections.
Inventors:
YU GUOCAN (CN)
LIN XIN (CN)
YU XINYANG (CN)
LI HONGJIAN (CN)
LIN XIN (CN)
YU XINYANG (CN)
LI HONGJIAN (CN)
Application Number:
PCT/CN2023/103069
Publication Date:
March 21, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C08G79/04; A61K9/127; A61K47/34; A61K48/00
Foreign References:
| CN115197431A | 2022-10-18 | |||
| CN102335432A | 2012-02-01 | |||
| CN113993839A | 2022-01-28 | |||
| CN114940756A | 2022-08-26 | |||
| US20050119450A1 | 2005-06-02 | |||
| US20050131200A1 | 2005-06-16 |
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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