Title:
RECOMBINANT PROTEIN COMPRISING PROTEIN DERIVED FROM FOOT-AND-MOUTH DISEASE VIRUS TYPE O CAPSID PROTEIN AND SFC PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/085686
Kind Code:
A1
Abstract:
The present invention relates to: a recombinant protein comprising a foot-and-mouth disease virus (FMDV) virus-like particle (VLP) and the fragment crystallizable (Fc) region of a porcine-derived immunoglobulin linked to the surface of the VLP; and a vaccine composition comprising the recombinant protein. The recombinant protein of the present invention is capable of forming a self-assembled structure comprising a VLP using a protein derived from FMDV capsid protein, which is an antigen protein, and swine Fc protein located on the surface of the VLP. Thus, when a vaccine composition comprising the recombinant protein is used, a specific antibody against FMDV can be effectively produced.
Inventors:
SHIN HYUN-JIN (KR)
Application Number:
PCT/KR2023/016269
Publication Date:
April 25, 2024
Filing Date:
October 19, 2023
Export Citation:
Assignee:
IAC IN NAT UNIV CHUNGNAM (KR)
International Classes:
C07K14/005; A61K39/125; A61P31/14; C12N15/62
Domestic Patent References:
| WO2002000251A1 | 2002-01-03 |
Foreign References:
| KR20190030223A | 2019-03-21 | |||
| CN110777160A | 2020-02-11 | |||
| KR20190039256A | 2019-04-10 |
Other References:
SHIN, H.-J. et al. Development of swine Fc conjugated Serotype O Foot and mouth disease virus like particles. The Journal of Immunology. 01 May 2022, 208.1_Supplement, 124.07. Retrieved from .
BELSHAM GRAHAM J.: "Towards improvements in foot-and-mouth disease vaccine performance", ACTA VETERINARIA SCANDINAVICA, vol. 62, no. 1, 1 December 2020 (2020-12-01), pages 20, XP093068682, DOI: 10.1186/s13028-020-00519-1
BELSHAM GRAHAM J.: "Towards improvements in foot-and-mouth disease vaccine performance", ACTA VETERINARIA SCANDINAVICA, vol. 62, no. 1, 1 December 2020 (2020-12-01), pages 20, XP093068682, DOI: 10.1186/s13028-020-00519-1
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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