Title:
PERIODONTAL TOPICAL DELIVERY PREPARATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169073
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medical materials. Provided in the present disclosure are a periodontal topical delivery preparation, and a preparation method therefor and the use thereof. The method for preparing the periodontal topical delivery preparation comprises: performing an esterification reaction on polyvinyl alcohol and 3,4-dihydroxyphenylalanine to obtain a PD polymer; performing a reaction on the PD polymer and manganese dioxide nanosheets, wherein a phenolic hydroxyl group on the PD polymer is chelated to metal manganese ions; and constructing an ROS cluster-responsive and NIR photothermoresponsive MnO2 nanosheet mussel biomimetic composite material as the periodontal topical delivery preparation using good wet-bonding properties of DOPA and the enzyme-mimic activities of manganese dioxide nanosheets. The periodontal topical delivery preparation can effectively scavenge excessive ROS caused by periodontitis, perform sustained and effective sterilization, improve the progression of periodontitis and suppress the problem of periodontal supporting tissue loss caused by periodontitis.
Inventors:
CHEN TAO (CN)
HU SHANSHAN (CN)
WANG LIPING (CN)
TANG HAN (CN)
WANG SI (CN)
JI PING (CN)
HU SHANSHAN (CN)
WANG LIPING (CN)
TANG HAN (CN)
WANG SI (CN)
JI PING (CN)
Application Number:
PCT/CN2023/070598
Publication Date:
September 14, 2023
Filing Date:
January 05, 2023
Export Citation:
Assignee:
UNIV CHONGQING MEDICAL (CN)
International Classes:
A61K9/06; A61K33/32; A61K47/32; A61K47/52; A61P1/02; A61P29/00; A61P31/02; C08F8/32; C08F16/06
Foreign References:
| CN114533660A | 2022-05-27 | |||
| CN113049563A | 2021-06-29 | |||
| US20200247101A1 | 2020-08-06 |
Other References:
刘蓉瑾 (LIU, RONGJIN): "含儿茶酚基聚合物的制备及其性能研究 (Study on Preparation and Properties of Catechol-Based Polymers)", 中国优秀硕士学位论文全文数据库 工程科技I辑 (CHINESE MASTER’S THESES FULL-TEXT DATABASE (ENGINEERING SCIENCE AND TECHNOLOGY I)), no. 12, 15 December 2015 (2015-12-15), ISSN: 1674-0246
严雅丽 (YAN, YALI): "层状MnO2纳米材料的制备及其非光照条件下抗菌性能研究 (Study on the Fabrication of Layered MnO2 Nanomaterials and Their Antibacterial Activity in the Dark)", 中国优秀硕士学位论文全文数据库 工程科技I辑 (CHINESE MASTER’S THESES FULL-TEXT DATABASE (ENGINEERING SCIENCE AND TECHNOLOGY I)), no. 1, 15 January 2022 (2022-01-15), ISSN: 1674-0246
WANG, SHENQIANG ET AL.: "Injectable Redox and Light Responsive MnO2 Hybrid Hydrogel for Simultaneous Melanoma Therapy and Multidrug-Resistant Bacteria-Infected Wound Healing", BIOMATERIALS, vol. 260, 12 August 2020 (2020-08-12), XP086262140, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2020.120314
严雅丽 (YAN, YALI): "层状MnO2纳米材料的制备及其非光照条件下抗菌性能研究 (Study on the Fabrication of Layered MnO2 Nanomaterials and Their Antibacterial Activity in the Dark)", 中国优秀硕士学位论文全文数据库 工程科技I辑 (CHINESE MASTER’S THESES FULL-TEXT DATABASE (ENGINEERING SCIENCE AND TECHNOLOGY I)), no. 1, 15 January 2022 (2022-01-15), ISSN: 1674-0246
WANG, SHENQIANG ET AL.: "Injectable Redox and Light Responsive MnO2 Hybrid Hydrogel for Simultaneous Melanoma Therapy and Multidrug-Resistant Bacteria-Infected Wound Healing", BIOMATERIALS, vol. 260, 12 August 2020 (2020-08-12), XP086262140, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2020.120314
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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