Title:
BONE ADHESIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169074
Kind Code:
A1
Abstract:
The present disclosure relates to the technical field of medical materials, and provides a bone adhesive, a preparation method therefor and an application thereof. According to the bone adhesive, levodopa (L-DOPA) is grafted on polyvinyl alcohol (PVA), phenolic hydroxyl on L-DOPA is combined with ZIF-8 to form multifunctional bionic ZIF-8 bone glue, the wet adhesion characteristic of L-DOPA molecules containing a large number of catechol structures is integrated by taking a metal organic framework ZIF-8 as a core, and the PVA having good biocompatibility is used as a carrier to construct a novel bone glue (L-DPZ bone glue) which has the functions of good bone adhesion performance, biocompatibility, osteogenesis characteristics, injectability, etc. The bone adhesive can promote bone adhesion and bone healing processes of severe bone wounds such as complex bone fractures and bone defects, and has a wide clinical application prospect.
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Inventors:
CHEN TAO (CN)
HU SHANSHAN (CN)
WANG SHAN (CN)
ZHAI QIMING (CN)
JI PING (CN)
HU SHANSHAN (CN)
WANG SHAN (CN)
ZHAI QIMING (CN)
JI PING (CN)
Application Number:
PCT/CN2023/070599
Publication Date:
September 14, 2023
Filing Date:
January 05, 2023
Export Citation:
Assignee:
UNIV CHONGQING MEDICAL (CN)
International Classes:
A61L27/16; A61L27/52; A61L27/54; C08G81/00
Foreign References:
| CN114470320A | 2022-05-13 | |||
| CN102596275A | 2012-07-18 | |||
| CN109705369A | 2019-05-03 | |||
| US20210106718A1 | 2021-04-15 | |||
| US20210163797A1 | 2021-06-03 |
Other References:
刘蓉瑾 (LIU, RONGJIN): "含儿茶酚基聚合物的制备及其性能研究 (Study on Preparation and Properties of Catechol-Based Polymers)", 中国优秀硕士学位论文全文数据库 工程技术I辑 (ENGINEERING SCIENCE AND TECHNOLOGY I, CHINESE MASTER’S THESES FULL-TEXT DATABASE), no. 12, 15 December 2015 (2015-12-15)
LIU YANHUA, ZHU ZHOU, PEI XIBO, ZHANG XIN, CHENG XINTING, HU SHANSHAN, GAO XIAOMENG, WANG JIAN, CHEN JUNYU, WAN QIANBING: "ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 33, 19 August 2020 (2020-08-19), US , pages 36978 - 36995, XP093090459, ISSN: 1944-8244, DOI: 10.1021/acsami.0c12090
LIU YANHUA, ZHU ZHOU, PEI XIBO, ZHANG XIN, CHENG XINTING, HU SHANSHAN, GAO XIAOMENG, WANG JIAN, CHEN JUNYU, WAN QIANBING: "ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 33, 19 August 2020 (2020-08-19), US , pages 36978 - 36995, XP093090459, ISSN: 1944-8244, DOI: 10.1021/acsami.0c12090
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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