Title:
NANOMATERIAL CAPABLE OF RESISTING INFLAMMATIONS CAUSED BY INTERLEUKIN 1 AND TUMOR NECROSIS FACTORS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/082347
Kind Code:
A1
Abstract:
A nanomaterial capable of resisting inflammations caused by interleukin 1 and tumor necrosis factors, and a preparation method therefor and the use thereof. The nanomaterial used in the present invention has the advantages of a large specific surface area, being able to simultaneously couple with two drugs, IL-1Ra and sTNFRI, has a high drug loading capacity, prolongs the retention time of the protein drugs in the body, improves the targeting properties of the protein drugs at inflammation sites, can enhance the efficacy of the protein drugs and achieves good treatment effects in CIA (collagen-induced rheumatoid arthritis) mice, which provides potential methods and strategies for the treatment of rheumatoid arthritis.
Inventors:
ZHANG JINPING (CN)
YANG YI (CN)
GAO XIU (CN)
SHAO YU (CN)
YANG YI (CN)
GAO XIU (CN)
SHAO YU (CN)
Application Number:
PCT/CN2022/129767
Publication Date:
April 25, 2024
Filing Date:
November 04, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K38/20; A61K38/17; A61K47/59; A61P19/02; A61P29/00
Foreign References:
| CN101098712A | 2008-01-02 | |||
| CN111032864A | 2020-04-17 | |||
| CN114470223A | 2022-05-13 |
Other References:
MASAHIKO KOBAYASHI: "Role of interleukin‐1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage", ARTHRITIS & RHEUMATISM, WILEY INTERSCIENCE, US, vol. 52, no. 1, 1 January 2005 (2005-01-01), US , pages 128 - 135, XP093162167, ISSN: 0004-3591, DOI: 10.1002/art.20776
JIANG TAO, KAN HO-MAN, RAJPURA KOMAL, CARBONE ERICA J, LI YINGCUI, LO KEVIN W.-H: "Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, AMERICAN SCIENTIFIC PUBLISHERS, US, vol. 18, no. 4, 1 April 2018 (2018-04-01), US , pages 2310 - 2317, XP009554048, ISSN: 1533-4880, DOI: 10.1166/jnn.2018.14311
KHALED A. ELSAID: "Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect", JOURNAL OF EXPERIMENTAL ORTHOPAEDICS, vol. 3, no. 1, 1 December 2016 (2016-12-01), XP093162170, ISSN: 2197-1153, DOI: 10.1186/s40634-016-0054-4
JIANG TAO, KAN HO-MAN, RAJPURA KOMAL, CARBONE ERICA J, LI YINGCUI, LO KEVIN W.-H: "Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, AMERICAN SCIENTIFIC PUBLISHERS, US, vol. 18, no. 4, 1 April 2018 (2018-04-01), US , pages 2310 - 2317, XP009554048, ISSN: 1533-4880, DOI: 10.1166/jnn.2018.14311
KHALED A. ELSAID: "Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect", JOURNAL OF EXPERIMENTAL ORTHOPAEDICS, vol. 3, no. 1, 1 December 2016 (2016-12-01), XP093162170, ISSN: 2197-1153, DOI: 10.1186/s40634-016-0054-4
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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