Title:
FLUORESCENT [1,2,3]TRIAZOLO[4,5-F]-2,1,3-BENZOTHIADIAZOLE DERIVATIVES FOR ACCELERATED CANCER THERANOSTIC
Document Type and Number:
WIPO Patent Application WO/2024/082959
Kind Code:
A1
Abstract:
The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. This fluorescent compound is then encapsulated by polymer matrix to yield nanoaggregates which is confirmed to show an excellent photothermal conversion efficiency while maintaining a high fluorescence quantum yield. Consequently, the photothermal therapeutic efficacy can be improved by PTA-oriented accumulation of nanoaggregates, compared with the barely enhanced permeability and retention (EPR) effect. The in vitro and in vivo verification further confirmed that the nanoaggregates exhibit superior fluorescence-guided phototheranostics ability to eliminate tumors.
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Inventors:
TANG BENZHONG (CN)
XIE HUILIN (CN)
ZHANG CHEN (CN)
KWOK TSZ KIN (CN)
XIE HUILIN (CN)
ZHANG CHEN (CN)
KWOK TSZ KIN (CN)
Application Number:
PCT/CN2023/122903
Publication Date:
April 25, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
UNIV HONG KONG SCIENCE & TECH (CN)
International Classes:
C07D513/04; A61K31/433; A61P35/00
Domestic Patent References:
| WO2015023574A1 | 2015-02-19 |
Foreign References:
| CN105026518A | 2015-11-04 | |||
| CN114057773A | 2022-02-18 | |||
| CN114380847A | 2022-04-22 | |||
| CN113853376A | 2021-12-28 |
Other References:
SHIBO LV: "Rational design of a small organic photosensitizer for NIR-I imaging-guided synergistic photodynamic and photothermal therapy", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 10, no. 17, 24 August 2022 (2022-08-24), GB , pages 4785 - 4795, XP093160338, ISSN: 2047-4830, DOI: 10.1039/D2BM00661H
GUO, BING ET AL: "Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 5, 18 November 2019 (2019-11-18), XP072407082, DOI: 10.1002/adfm.201907093
DUAN，YUKUN ET AL: "Nanostructural control enables optimized photoacoustic-fluorescence-magnetic resonance multimodal imaging and phototherapy of brain tumor", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 1, 4 November 2019 (2019-11-04), XP072406406, DOI: 10.1002/adfm.201907077
SHENGLIANG LI: "In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 10, 27 October 2020 (2020-10-27), US , pages 13681 - 13690, XP093160340, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c05885
GUO, BING ET AL: "Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 5, 18 November 2019 (2019-11-18), XP072407082, DOI: 10.1002/adfm.201907093
DUAN，YUKUN ET AL: "Nanostructural control enables optimized photoacoustic-fluorescence-magnetic resonance multimodal imaging and phototherapy of brain tumor", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 1, 4 November 2019 (2019-11-04), XP072406406, DOI: 10.1002/adfm.201907077
SHENGLIANG LI: "In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 10, 27 October 2020 (2020-10-27), US , pages 13681 - 13690, XP093160340, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c05885
Attorney, Agent or Firm:
SHENZHEN I & W INTELLECTUAL PROPERTY CORPORATION (CN)
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