Title:
FLUORESCENT [1,2,3]TRIAZOLO[4,5-F]-2,1,3-BENZOTHIADIAZOLE DERIVATIVES FOR PHOTOTHERMAL CANCER THERANOSTIC
Document Type and Number:
WIPO Patent Application WO/2024/082958
Kind Code:
A1
Abstract:
The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. The present invention also shows application for imaging-guided phototheranostic with the integration of both photodynamic therapies and photothermal therapies. The in vitro and in vivo verification further confirmed that this system exhibits outstanding fluorescence-guided phototheranostics ability to eliminate tumors effectively.
Inventors:
TANG BENZHONG (CN)
XIE HUILIN (CN)
KWOK TSZ KIN (CN)
XIE HUILIN (CN)
KWOK TSZ KIN (CN)
Application Number:
PCT/CN2023/122882
Publication Date:
April 25, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
UNIV HONG KONG SCIENCE & TECH (CN)
International Classes:
C07D513/04; A61K31/433; A61P35/00
Foreign References:
| CN112566911A | 2021-03-26 | |||
| CN113853376A | 2021-12-28 |
Other References:
YUKUN DUAN; DEHONG HU; BING GUO; QI SHI; MIN WU; SHIDANG XU; KENRY; XIN LIU; JIANWEN JIANG; ZONGHAI SHENG; HAIRONG ZHENG; BIN LIU: "Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 1, 4 November 2019 (2019-11-04), DE , pages 1 - 12, XP072406406, ISSN: 1616-301X, DOI: 10.1002/adfm.201907077
SHENGLIANG LI , HAOTING CHEN , HAILE LIU , LU LIU , YUAN YUAN , CONG MAO , WEI ZHANG , XIAODONG ZHANG , WEISHENG GUO , XING-JIE LI: "In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation", ACS NANO, vol. 14, no. 10, 27 October 2020 (2020-10-27), US , pages 13681 - 13690, XP093160340, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c05885
BING GUO; ZEMIN HUANG; QI SHI; ESHU MIDDHA; SHIDANG XU; LING LI; MIN WU; JIANWEN JIANG; QINGLIAN HU; ZHENGWEI FU; BIN LIU: "Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 5, 18 November 2019 (2019-11-18), DE , pages 1 - 11, XP072407082, ISSN: 1616-301X, DOI: 10.1002/adfm.201907093
SHENGLIANG LI , HAOTING CHEN , HAILE LIU , LU LIU , YUAN YUAN , CONG MAO , WEI ZHANG , XIAODONG ZHANG , WEISHENG GUO , XING-JIE LI: "In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation", ACS NANO, vol. 14, no. 10, 27 October 2020 (2020-10-27), US , pages 13681 - 13690, XP093160340, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c05885
BING GUO; ZEMIN HUANG; QI SHI; ESHU MIDDHA; SHIDANG XU; LING LI; MIN WU; JIANWEN JIANG; QINGLIAN HU; ZHENGWEI FU; BIN LIU: "Organic Small Molecule Based Photothermal Agents with Molecular Rotors for Malignant Breast Cancer Therapy", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 5, 18 November 2019 (2019-11-18), DE , pages 1 - 11, XP072407082, ISSN: 1616-301X, DOI: 10.1002/adfm.201907093
Attorney, Agent or Firm:
SHENZHEN I & W INTELLECTUAL PROPERTY CORPORATION (CN)
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